Physical dependence
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Overview
Physical dependence (or drug dependence) refers to a state resulting from habitual use of a drug, where negative physical withdrawal symptoms result from abrupt discontinuation.[1] From the point of view of the dependent person, "dependence is duress," argues addiction researcher Griffith Edwards.[2]
Symptoms
Increased heart rate and/or blood pressure, sweating, and tremors are common signs of withdrawal. More serious symptoms such as confusion, seizures, and visual hallucinations indicate a serious emergency and the need for immediate medical care. Alcohol, benzodiazepines, and barbiturates are the only commonly abused substances that can be fatal in withdrawal. Abrupt withdrawal from other drugs, such as opioids or psychostimulants, can exaggerate mild to moderate neurotoxic side effects due to hyperthermia and generation of free radicals[3], but life-threatening complications are very rare.
Treatment
Treatment for physical dependence depends upon the drug being withdrawn and often includes administration of another drug, especially for substances that can be dangerous when abruptly discontinued. Treatment usually requires the initiation and then tapering of a medication that has a similar action in the brain but a longer half-life.
Difference from Addiction
Physical dependence is different from drug addiction. The latter is often characterized by a psychological need for a drug, while the former can often be the result of legal, long-term use of medicine.[4]
Drugs that cause physical dependence
- barbiturates
- benzodiazepines
- ethyl alcohol (alcoholic beverage)
- GHB
- methaqualone (Quaalude®)
- nicotine
- opioids
- amphetamines
References
- ↑ Drug Addiction. CNN.
- ↑ Griffith Edwards. Alcohol: The World's Favourite Drug. 1st US ed. Thomas Dunne Books: 2002. ISBN 0-312-28387-3. P 72.
- ↑ Sharma HS, Sjöquist PO, Ali SF. "Drugs of abuse-induced hyperthermia, blood-brain barrier dysfunction and neurotoxicity: neuroprotective effects of a new antioxidant compound H-290/51." Current Pharmaceutical Design. 2007;13(18):1903-23. PMID 17584116
- ↑ Drug Abuse - Addiction vs. Dependence. Our Chronic Pain Mission.
See also
- Addiction
- Addiction recovery groups
- Discontinuation syndrome
- Rebound insomnia
External links
- Drugs causing physical dependence taken from Merck Manual of Diagnosis and Therapy, Section 15, Chapter 195" Merck Manual.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
