XCR1

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Identifiers
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External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
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Wikidata
View/Edit Human

The "C" sub-family of chemokine receptors contains only one member: XCR1, the receptor for XCL1 and XCL2 (or lymphotactin-1 and -2).

XCR1 is also known as GPR5.

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

External links

• "Chemokine Receptors: XCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

• Maghazachi AA (1999). "Intracellular signalling pathways induced by chemokines in natural killer cells". Cell. Signal. 11 (6): 385–90. doi:10.1016/S0898-6568(99)00008-X. PMID 10400311.
• Gao JL, Kuhns DB, Tiffany HL, et al. (1993). "Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor". J. Exp. Med. 177 (5): 1421–7. doi:10.1084/jem.177.5.1421. PMC 2191019. PMID 7683036.
• Heiber M, Docherty JM, Shah G, et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors". DNA Cell Biol. 14 (1): 25–35. doi:10.1089/dna.1995.14.25. PMID 7832990.
• Yoshida T, Imai T, Kakizaki M, et al. (1998). "Identification of single C motif-1/lymphotactin receptor XCR1". J. Biol. Chem. 273 (26): 16551–4. doi:10.1074/jbc.273.26.16551. PMID 9632725.
• Shan L, Qiao X, Oldham E, et al. (2000). "Identification of viral macrophage inflammatory protein (vMIP)-II as a ligand for GPR5/XCR1". Biochem. Biophys. Res. Commun. 268 (3): 938–41. doi:10.1006/bbrc.2000.2235. PMID 10679309.
• Maho A, Bensimon A, Vassart G, Parmentier M (2000). "Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome". Cytogenet. Cell Genet. 87 (3–4): 265–8. doi:10.1159/000015443. PMID 10702689.
• Kurt RA, Bauck M, Harma S, et al. (2001). "Role of C chemokine lymphotactin in mediating recruitment of antigen-specific CD62L(lo) cells in vitro and in vivo". Cell. Immunol. 209 (2): 83–8. doi:10.1006/cimm.2001.1790. PMID 11446740.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Shinkai H, Morozumi T, Toki D, et al. (2005). "Genomic structure of eight porcine chemokine receptors and intergene sharing of an exon between CCR1 and XCR1". Gene. 349: 55–66. doi:10.1016/j.gene.2004.10.017. PMID 15777643.
• Lüttichau HR, Johnsen AH, Jurlander J, et al. (2007). "Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3". J. Biol. Chem. 282 (24): 17794–805. doi:10.1074/jbc.M702001200. PMID 17403668.

External links

• XCR1+receptor,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.