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{{redirect|LTBR|the airport in Turkey with that ICAO code|Yenişehir Airport}}
{{redirect|LTBR|the airport in Turkey with that ICAO code|Yenişehir Airport}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Lymphotoxin beta receptor''' ('''LTBR'''), also known as '''tumor necrosis factor receptor superfamily member 3''' ('''TNFRSF3'''), is a [[cell surface receptor]] for [[lymphotoxin]] involved in [[apoptosis]] and [[cytokine]] release.<ref name="entrez">{{cite web | title = Entrez Gene: LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4055| accessdate = }}</ref><ref name="pmid8486360">{{cite journal |vauthors=Baens M, Chaffanet M, Cassiman JJ, van den Berghe H, Marynen P | title = Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid | journal = Genomics | volume = 16 | issue = 1 | pages = 214–8 |date=April 1993 | pmid = 8486360 | doi = 10.1006/geno.1993.1161 | url =  }}</ref><ref name="pmid8171323">{{cite journal |vauthors=Crowe PD, VanArsdale TL, Walter BN, Ware CF, Hession C, Ehrenfels B, Browning JL, Din WS, Goodwin RG, Smith CA | title = A lymphotoxin-beta-specific receptor | journal = Science | volume = 264 | issue = 5159 | pages = 707–10 |date=April 1994 | pmid = 8171323 | doi = 10.1126/science.8171323 | url =  }}</ref> It is a member of the [[tumor necrosis factor receptor]] superfamily.
'''Lymphotoxin beta receptor''' ('''LTBR'''), also known as '''tumor necrosis factor receptor superfamily member 3''' ('''TNFRSF3'''), is a [[cell surface receptor]] for [[lymphotoxin]] involved in [[apoptosis]] and [[cytokine]] release.<ref name="entrez">{{cite web | title = Entrez Gene: LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4055| accessdate = }}</ref><ref name="pmid8486360">{{cite journal |vauthors=Baens M, Chaffanet M, Cassiman JJ, van den Berghe H, Marynen P | title = Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid | journal = Genomics | volume = 16 | issue = 1 | pages = 214–8 |date=April 1993 | pmid = 8486360 | doi = 10.1006/geno.1993.1161 | url =  }}</ref><ref name="pmid8171323">{{cite journal |vauthors=Crowe PD, VanArsdale TL, Walter BN, Ware CF, Hession C, Ehrenfels B, Browning JL, Din WS, Goodwin RG, Smith CA | title = A lymphotoxin-beta-specific receptor | journal = Science | volume = 264 | issue = 5159 | pages = 707–10 |date=April 1994 | pmid = 8171323 | doi = 10.1126/science.8171323 | url =  | bibcode =1994Sci...264..707C }}</ref> It is a member of the [[tumor necrosis factor receptor]] superfamily.


==Function==
==Function==
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==Interactions==
==Interactions==
Lymphotoxin beta receptor has been shown to [[Protein-protein interaction|interact]] with [[Diablo homolog]]<ref name=pmid12571250>{{cite journal |last=Kuai |first=Jun |authorlink= |author2=Nickbarg Elliott |author3=Wooters Joe |author4=Qiu Yongchang |author5=Wang Jack |author6=Lin Lih-Ling  |date=Apr 2003 |title=Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis |journal=J. Biol. Chem. |volume=278 |issue=16 |pages=14363–9 |publisher= |location = United States| issn = 0021-9258| pmid = 12571250 |doi = 10.1074/jbc.M208672200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[TRAF3]].<ref name=pmid9122217>{{cite journal |doi=10.1073/pnas.94.6.2460 |last=VanArsdale |first=T L |authorlink= |author2=VanArsdale S L |author3=Force W R |author4=Walter B N |author5=Mosialos G |author6=Kieff E |author7=Reed J C |author8=Ware C F  |authorlink6=Elliott D. Kieff|date=Mar 1997 |title=Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=94 |issue=6 |pages=2460–5 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 9122217 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=20110 }}</ref><ref name=pmid10207006>{{cite journal |doi=10.1074/jbc.274.17.11868 |last=Wu |first=M Y |authorlink= |author2=Wang P Y |author3=Han S H |author4=Hsieh S L  |date=Apr 1999 |title=The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells |journal=J. Biol. Chem. |volume=274 |issue=17 |pages=11868–73 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10207006 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid9162022>{{cite journal |doi=10.1074/jbc.272.22.14029 |last=Marsters |first=S A |authorlink= |author2=Ayres T M |author3=Skubatch M |author4=Gray C L |author5=Rothe M |author6=Ashkenazi A  |date=May 1997 |title=Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1 |journal=J. Biol. Chem. |volume=272 |issue=22 |pages=14029–32 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9162022 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
Lymphotoxin beta receptor has been shown to [[Protein-protein interaction|interact]] with [[Diablo homolog]]<ref name=pmid12571250>{{cite journal |last=Kuai |first=Jun |authorlink= |author2=Nickbarg Elliott |author3=Wooters Joe |author4=Qiu Yongchang |author5=Wang Jack |author6=Lin Lih-Ling  |date=Apr 2003 |title=Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis |journal=J. Biol. Chem. |volume=278 |issue=16 |pages=14363–9 |publisher= |location = United States| issn = 0021-9258| pmid = 12571250 |doi = 10.1074/jbc.M208672200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[TRAF3]].<ref name=pmid9122217>{{cite journal |doi=10.1073/pnas.94.6.2460 |last=VanArsdale |first=T L |authorlink= |author2=VanArsdale S L |author3=Force W R |author4=Walter B N |author5=Mosialos G |author6=Kieff E |author7=Reed J C |author8=Ware C F  |authorlink6=Elliott D. Kieff|date=Mar 1997 |title=Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=94 |issue=6 |pages=2460–5 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 9122217 | bibcode =1997PNAS...94.2460V | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=20110 }}</ref><ref name=pmid10207006>{{cite journal |doi=10.1074/jbc.274.17.11868 |last=Wu |first=M Y |authorlink= |author2=Wang P Y |author3=Han S H |author4=Hsieh S L  |date=Apr 1999 |title=The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells |journal=J. Biol. Chem. |volume=274 |issue=17 |pages=11868–73 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10207006 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid9162022>{{cite journal |doi=10.1074/jbc.272.22.14029 |last=Marsters |first=S A |authorlink= |author2=Ayres T M |author3=Skubatch M |author4=Gray C L |author5=Rothe M |author6=Ashkenazi A  |date=May 1997 |title=Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1 |journal=J. Biol. Chem. |volume=272 |issue=22 |pages=14029–32 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9162022 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
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* {{cite journal  |vauthors=Elewaut D, Ware CF |title=The unconventional role of LT alpha beta in T cell differentiation. |journal=Trends Immunol. |volume=28 |issue= 4 |pages= 169–75 |year= 2007 |pmid= 17336158 |doi= 10.1016/j.it.2007.02.005 }}
* {{cite journal  |vauthors=Elewaut D, Ware CF |title=The unconventional role of LT alpha beta in T cell differentiation. |journal=Trends Immunol. |volume=28 |issue= 4 |pages= 169–75 |year= 2007 |pmid= 17336158 |doi= 10.1016/j.it.2007.02.005 }}
* {{cite journal  |vauthors=Browning JL, Ngam-ek A, Lawton P, etal |title=Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. |journal=Cell |volume=72 |issue= 6 |pages= 847–56 |year= 1993 |pmid= 7916655 |doi=10.1016/0092-8674(93)90574-A  }}
* {{cite journal  |vauthors=Browning JL, Ngam-ek A, Lawton P, etal |title=Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. |journal=Cell |volume=72 |issue= 6 |pages= 847–56 |year= 1993 |pmid= 7916655 |doi=10.1016/0092-8674(93)90574-A  }}
* {{cite journal  |vauthors=Crowe PD, VanArsdale TL, Walter BN, etal |title=A lymphotoxin-beta-specific receptor. |journal=Science |volume=264 |issue= 5159 |pages= 707–10 |year= 1994 |pmid= 8171323 |doi=10.1126/science.8171323  }}
* {{cite journal  |vauthors=Crowe PD, VanArsdale TL, Walter BN, etal |title=A lymphotoxin-beta-specific receptor. |journal=Science |volume=264 |issue= 5159 |pages= 707–10 |year= 1994 |pmid= 8171323 |doi=10.1126/science.8171323  |bibcode=1994Sci...264..707C }}
* {{cite journal  |vauthors=Baens M, Chaffanet M, Cassiman JJ, etal |title=Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid. |journal=Genomics |volume=16 |issue= 1 |pages= 214–8 |year= 1993 |pmid= 8486360 |doi= 10.1006/geno.1993.1161 }}
* {{cite journal  |vauthors=Baens M, Chaffanet M, Cassiman JJ, etal |title=Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid. |journal=Genomics |volume=16 |issue= 1 |pages= 214–8 |year= 1993 |pmid= 8486360 |doi= 10.1006/geno.1993.1161 }}
* {{cite journal  |vauthors=Baens M, Aerssens J, van Zand K, etal |title=Isolation and regional assignment of human chromosome 12p cDNAs. |journal=Genomics |volume=29 |issue= 1 |pages= 44–52 |year= 1996 |pmid= 8530100 |doi= 10.1006/geno.1995.1213 }}
* {{cite journal  |vauthors=Baens M, Aerssens J, van Zand K, etal |title=Isolation and regional assignment of human chromosome 12p cDNAs. |journal=Genomics |volume=29 |issue= 1 |pages= 44–52 |year= 1996 |pmid= 8530100 |doi= 10.1006/geno.1995.1213 }}
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* {{cite journal  |vauthors=Nakano H, Oshima H, Chung W, etal |title=TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 14661–4 |year= 1996 |pmid= 8663299 |doi=10.1074/jbc.271.25.14661  }}
* {{cite journal  |vauthors=Nakano H, Oshima H, Chung W, etal |title=TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 14661–4 |year= 1996 |pmid= 8663299 |doi=10.1074/jbc.271.25.14661  }}
* {{cite journal  |vauthors=Matsumoto M, Hsieh TY, Zhu N, etal |title=Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor. |journal=J. Virol. |volume=71 |issue= 2 |pages= 1301–9 |year= 1997 |pmid= 8995654 |doi=  | pmc=191185  }}
* {{cite journal  |vauthors=Matsumoto M, Hsieh TY, Zhu N, etal |title=Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor. |journal=J. Virol. |volume=71 |issue= 2 |pages= 1301–9 |year= 1997 |pmid= 8995654 |doi=  | pmc=191185  }}
* {{cite journal  |vauthors=VanArsdale TL, VanArsdale SL, Force WR, etal |title=Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 6 |pages= 2460–5 |year= 1997 |pmid= 9122217 |doi=10.1073/pnas.94.6.2460  | pmc=20110  }}
* {{cite journal  |vauthors=VanArsdale TL, VanArsdale SL, Force WR, etal |title=Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 6 |pages= 2460–5 |year= 1997 |pmid= 9122217 |doi=10.1073/pnas.94.6.2460  | pmc=20110  |bibcode=1997PNAS...94.2460V }}
* {{cite journal  |vauthors=Wu MY, Hsu TL, Lin WW, etal |title=Serine/threonine kinase activity associated with the cytoplasmic domain of the lymphotoxin-beta receptor in HepG2 cells. |journal=J. Biol. Chem. |volume=272 |issue= 27 |pages= 17154–9 |year= 1997 |pmid= 9202035 |doi=10.1074/jbc.272.27.17154  }}
* {{cite journal  |vauthors=Wu MY, Hsu TL, Lin WW, etal |title=Serine/threonine kinase activity associated with the cytoplasmic domain of the lymphotoxin-beta receptor in HepG2 cells. |journal=J. Biol. Chem. |volume=272 |issue= 27 |pages= 17154–9 |year= 1997 |pmid= 9202035 |doi=10.1074/jbc.272.27.17154  }}
* {{cite journal  |vauthors=Chen CM, You LR, Hwang LH, Lee YH |title=Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta receptor. |journal=J. Virol. |volume=71 |issue= 12 |pages= 9417–26 |year= 1997 |pmid= 9371602 |doi=  | pmc=230246  }}
* {{cite journal  |vauthors=Chen CM, You LR, Hwang LH, Lee YH |title=Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta receptor. |journal=J. Virol. |volume=71 |issue= 12 |pages= 9417–26 |year= 1997 |pmid= 9371602 |doi=  | pmc=230246  }}

Latest revision as of 03:27, 25 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Lymphotoxin beta receptor (LTBR), also known as tumor necrosis factor receptor superfamily member 3 (TNFRSF3), is a cell surface receptor for lymphotoxin involved in apoptosis and cytokine release.[1][2][3] It is a member of the tumor necrosis factor receptor superfamily.

Function

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis.[1]

Not only does the LTBR help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. LTBR is also essential for development and organization of the secondary lymphoid organs and chemokine release.[4]

Structure

The Ramachandran plots show that 64.6% of all residues were in a favored region. This structure was found using X-ray diffraction. The resolution is 3.50 angstroms. The alpha and beta angles are 90 degrees while the gamma angle is 120 degrees.[5]

Interactions

Lymphotoxin beta receptor has been shown to interact with Diablo homolog[6] and TRAF3.[7][8][9]

References

  1. ↑ 1.0 1.1 "Entrez Gene: LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)".
  2. ↑ Baens M, Chaffanet M, Cassiman JJ, van den Berghe H, Marynen P (April 1993). "Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid". Genomics. 16 (1): 214–8. doi:10.1006/geno.1993.1161. PMID 8486360.
  3. ↑ Crowe PD, VanArsdale TL, Walter BN, Ware CF, Hession C, Ehrenfels B, Browning JL, Din WS, Goodwin RG, Smith CA (April 1994). "A lymphotoxin-beta-specific receptor". Science. 264 (5159): 707–10. Bibcode:1994Sci...264..707C. doi:10.1126/science.8171323. PMID 8171323.
  4. ↑ Chang YH, Hsieh SL, Chen MC, Lin WW (August 2002). "Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation". Exp. Cell Res. 278 (2): 166–74. doi:10.1006/excr.2002.5573. PMID 12169272.
  5. ↑ "MolProbity Ramachandran analysis" (PDF).
  6. ↑ Kuai, Jun; Nickbarg Elliott; Wooters Joe; Qiu Yongchang; Wang Jack; Lin Lih-Ling (Apr 2003). "Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis". J. Biol. Chem. United States. 278 (16): 14363–9. doi:10.1074/jbc.M208672200. ISSN 0021-9258. PMID 12571250.
  7. ↑ VanArsdale, T L; VanArsdale S L; Force W R; Walter B N; Mosialos G; Kieff E; Reed J C; Ware C F (Mar 1997). "Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 94 (6): 2460–5. Bibcode:1997PNAS...94.2460V. doi:10.1073/pnas.94.6.2460. ISSN 0027-8424. PMC 20110. PMID 9122217.
  8. ↑ Wu, M Y; Wang P Y; Han S H; Hsieh S L (Apr 1999). "The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells". J. Biol. Chem. UNITED STATES. 274 (17): 11868–73. doi:10.1074/jbc.274.17.11868. ISSN 0021-9258. PMID 10207006.
  9. ↑ Marsters, S A; Ayres T M; Skubatch M; Gray C L; Rothe M; Ashkenazi A (May 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". J. Biol. Chem. UNITED STATES. 272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. ISSN 0021-9258. PMID 9162022.

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=Lymphotoxin_beta_receptor&oldid=1528423"