CCR10: Difference between revisions

VALUE_ERROR (nil)
Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

VisualWikitext

Latest revision as of 09:19, 30 August 2017

C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene.^[1]^[2]

Function

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.^[2]

CCR10 is a chemokine receptor. Its ligands are CCL27 and CCL28.^[3] This receptor is normally expressed by melanocytes,^[4] plasma cells and skin-homing T cells. B16 melanoma cell transduction of CCR10 significantly increases the development of lymph node metastasis in mice after inoculation in the skin,^[5] suggesting a role for the receptor in directing metastasis. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation.^[6]

References

↑ Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (Mar 1995). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics. 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889.
↑ ^2.0 ^2.1 "Entrez Gene: CCR10 chemokine (C-C motif) receptor 10".
↑ Balkwill F (July 2004). "Cancer and the chemokine network". Nat. Rev. Cancer. 4 (7): 540–50. doi:10.1038/nrc1388. PMID 15229479.
↑ Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, Müller A, McClanahan TK, Dieu-Nosjean MC, Orozco R, Ruzicka T, Lehmann P, Oldham E, Zlotnik A (April 2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". J. Immunol. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697.
↑ Murakami T, Cardones AR, Finkelstein SE, Restifo NP, Klaunberg BA, Nestle FO, Castillo SS, Dennis PA, Hwang ST (November 2003). "Immune evasion by murine melanoma mediated through CC chemokine receptor-10". J. Exp. Med. 198 (9): 1337–47. doi:10.1084/jem.20030593. PMC 2194242. PMID 14581607.
↑ Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, Lehto M, Wolff H, Yen D, Marxhausen H, To W, Sedgwick J, Ruzicka T, Lehmann P, Zlotnik A (February 2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900.

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Bonini JA, Martin SK, Dralyuk F, et al. (1997). "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3". DNA Cell Biol. 16 (10): 1249–56. doi:10.1089/dna.1997.16.1249. PMID 9364936.
Gosling J, Dairaghi DJ, Wang Y, et al. (2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK". J. Immunol. 164 (6): 2851–6. doi:10.4049/jimmunol.164.6.2851. PMID 10706668.
Jarmin DI, Rits M, Bota D, et al. (2000). "Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine". J. Immunol. 164 (7): 3460–4. doi:10.4049/jimmunol.164.7.3460. PMID 10725696.
Homey B, Wang W, Soto H, et al. (2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". J. Immunol. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697.
Wang W, Soto H, Oldham ER, et al. (2000). "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)". J. Biol. Chem. 275 (29): 22313–23. doi:10.1074/jbc.M001461200. PMID 10781587.
Pan J, Kunkel EJ, Gosslar U, et al. (2000). "A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues". J. Immunol. 165 (6): 2943–9. doi:10.4049/jimmunol.165.6.2943. PMID 10975800.
Patel L, Charlton SJ, Chambers JK, Macphee CH (2001). "Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations". Cytokine. 14 (1): 27–36. doi:10.1006/cyto.2000.0851. PMID 11298490.
Homey B, Alenius H, Müller A, et al. (2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Notohamiprodjo M, Segerer S, Huss R, et al. (2005). "CCR10 is expressed in cutaneous T-cell lymphoma". Int. J. Cancer. 115 (4): 641–7. doi:10.1002/ijc.20922. PMID 15700309.
Rodrigues-Lisoni FC, Mehet DK, Mehemet DK, et al. (2006). "In vitro and in vivo studies on CCR10 regulation by Annexin A1". FEBS Lett. 580 (5): 1431–8. doi:10.1016/j.febslet.2006.01.072. PMID 16460738.
Fujita Y, Abe R, Sasaki M, et al. (2006). "Presence of circulating CCR10+ T cells and elevated serum CTACK/CCL27 in the early stage of mycosis fungoides". Clin. Cancer Res. 12 (9): 2670–5. doi:10.1158/1078-0432.CCR-05-1513. PMID 16675558.
Eksteen B, Miles A, Curbishley SM, et al. (2006). "Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10". J. Immunol. 177 (1): 593–603. doi:10.4049/jimmunol.177.1.593. PMID 16785557.
Harasawa H, Yamada Y, Hieshima K, et al. (2007). "Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphoma". Leuk. Lymphoma. 47 (10): 2163–73. doi:10.1080/10428190600775599. PMID 17071491.

External links

Human CCR10 genome location and CCR10 gene details page in the UCSC Genome Browser.
"Chemokine Receptors: CCR10". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[pmid7851889-1] Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (Mar 1995). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics. 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889.

[entrez-2] 2.0 ^2.1 "Entrez Gene: CCR10 chemokine (C-C motif) receptor 10".

[pmid15229479-3] Balkwill F (July 2004). "Cancer and the chemokine network". Nat. Rev. Cancer. 4 (7): 540–50. doi:10.1038/nrc1388. PMID 15229479.

[pmid10725697-4] Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, Müller A, McClanahan TK, Dieu-Nosjean MC, Orozco R, Ruzicka T, Lehmann P, Oldham E, Zlotnik A (April 2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". J. Immunol. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697.

[pmid14581607-5] Murakami T, Cardones AR, Finkelstein SE, Restifo NP, Klaunberg BA, Nestle FO, Castillo SS, Dennis PA, Hwang ST (November 2003). "Immune evasion by murine melanoma mediated through CC chemokine receptor-10". J. Exp. Med. 198 (9): 1337–47. doi:10.1084/jem.20030593. PMC 2194242. PMID 14581607.

[pmid11821900-6] Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, Lehto M, Wolff H, Yen D, Marxhausen H, To W, Sedgwick J, Ruzicka T, Lehmann P, Zlotnik A (February 2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900.

[1]

[2]

[3]

[4]

[5]

[6]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''C-C chemokine receptor type 10''' is a [[protein]] that in humans is encoded by the ''CCR10'' [[gene]].<ref name="pmid7851889">{{cite journal |vauthors=Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF | title = Cloning of human genes encoding novel G protein-coupled receptors | journal = Genomics | volume = 23 | issue = 3 | pages = 609–18 |date=Mar 1995 | pmid = 7851889 | pmc =  | doi = 10.1006/geno.1994.1549 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CCR10 chemokine (C-C motif) receptor 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2826| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Chemokine (C-C motif) receptor 10
- | HGNCid = 4474
- | Symbol = CCR10
- | AltSymbols =; GPR2
- | OMIM = 600240
- | ECnumber =
- | Homologene = 7271
- | MGIid = 1096320
- | GeneAtlas_image1 = PBB_GE_CCR10_220565_at_tn.png
- | Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016493 |text = C-C chemokine receptor activity}}
- | Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
- | Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 2826
-    | Hs_Ensembl = ENSG00000184451
-    | Hs_RefseqProtein = NP_057686
-    | Hs_RefseqmRNA = NM_016602
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 17
-    | Hs_GenLoc_start = 38084962
-    | Hs_GenLoc_end = 38087371
-    | Hs_Uniprot = P46092
-    | Mm_EntrezGene = 12777
-    | Mm_Ensembl = ENSMUSG00000044052
-    | Mm_RefseqmRNA = XM_894898
-    | Mm_RefseqProtein = XP_899991
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 11
-    | Mm_GenLoc_start = 100989088
-    | Mm_GenLoc_end = 100991533
-    | Mm_Uniprot = Q542A4
-  }}
-}}
-'''Chemokine (C-C motif) receptor 10''', also known as '''CCR10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCR10 chemokine (C-C motif) receptor 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2826| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+[[Chemokine]]s are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of [[leukocyte]]s through interactions with a subset of 7-transmembrane, [[G protein-coupled receptor]]s. Chemokines also play fundamental roles in the development, homeostasis, and function of the [[immune system]], and they have effects on cells of the central nervous system as well as on [[endothelial]] cells involved in [[angiogenesis]] or [[angiostasis]]. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.<ref name="entrez" />
-{{PBB_Summary
-| section_title =
+CCR10 is a [[chemokine]] receptor. Its ligands are [[CCL27]] and [[CCL28]].<ref name="pmid15229479">{{cite journal | author = Balkwill F | title = Cancer and the chemokine network | journal = Nat. Rev. Cancer | volume = 4 | issue = 7 | pages = 540–50 |date=July 2004 | pmid = 15229479 | doi = 10.1038/nrc1388 }}</ref> This receptor is normally expressed by melanocytes,<ref name="pmid10725697">{{cite journal |vauthors=Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, Müller A, McClanahan TK, Dieu-Nosjean MC, Orozco R, Ruzicka T, Lehmann P, Oldham E, Zlotnik A | title = Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC) | journal = J. Immunol. | volume = 164 | issue = 7 | pages = 3465–70 |date=April 2000 | pmid = 10725697 | doi = 10.4049/jimmunol.164.7.3465}}</ref> plasma cells and skin-homing T cells. B16 melanoma cell transduction of CCR10 significantly increases the development of [[lymph node]] [[metastasis]] in mice after inoculation in the skin,<ref name="pmid14581607">{{cite journal |vauthors=Murakami T, Cardones AR, Finkelstein SE, Restifo NP, Klaunberg BA, Nestle FO, Castillo SS, Dennis PA, Hwang ST | title = Immune evasion by murine melanoma mediated through CC chemokine receptor-10 | journal = J. Exp. Med. | volume = 198 | issue = 9 | pages = 1337–47 |date=November 2003 | pmid = 14581607 | pmc = 2194242 | doi = 10.1084/jem.20030593 }}</ref> suggesting a role for the receptor in directing metastasis. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation.<ref name="pmid11821900">{{cite journal |vauthors=Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, Lehto M, Wolff H, Yen D, Marxhausen H, To W, Sedgwick J, Ruzicka T, Lehmann P, Zlotnik A | title = CCL27-CCR10 interactions regulate T cell-mediated skin inflammation | journal = Nat. Med. | volume = 8 | issue = 2 | pages = 157–65 |date=February 2002 | pmid = 11821900 | doi = 10.1038/nm0202-157 }}</ref>
-| summary_text = Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: CCR10 chemokine (C-C motif) receptor 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2826| accessdate = }}</ref>
-}}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
+*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  }}
-| citations =
+*{{cite journal  | author=Bonini JA |title=Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3 |journal=DNA Cell Biol. |volume=16 |issue= 10 |pages= 1249–56 |year= 1997 |pmid= 9364936 |doi=10.1089/dna.1997.16.1249  |name-list-format=vanc| author2=Martin SK  | author3=Dralyuk F  | display-authors=3  | last4=Roe  | first4=Michael W.  | last5=Philipson  | first5=Louis H.  | last6=Steiner  | first6=Donald F.  }}
-*{{cite journal  | author=Marchese A, Docherty JM, Nguyen T, ''et al.'' |title=Cloning of human genes encoding novel G protein-coupled receptors. |journal=Genomics |volume=23 |issue= 3 |pages= 609-18 |year= 1995 |pmid= 7851889 |doi= 10.1006/geno.1994.1549 }}
+*{{cite journal  | author=Gosling J |title=Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK |journal=J. Immunol. |volume=164 |issue= 6 |pages= 2851–6 |year= 2000 |pmid= 10706668 |doi=  10.4049/jimmunol.164.6.2851|name-list-format=vanc| author2=Dairaghi DJ  | author3=Wang Y  | display-authors=3  | last4=Hanley  | first4=M  | last5=Talbot  | first5=D  | last6=Miao  | first6=Z  | last7=Schall  | first7=TJ  }}
-*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
+*{{cite journal  | author=Jarmin DI |title=Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine |journal=J. Immunol. |volume=164 |issue= 7 |pages= 3460–4 |year= 2000 |pmid= 10725696 |doi=  10.4049/jimmunol.164.7.3460|name-list-format=vanc| author2=Rits M  | author3=Bota D  | display-authors=3  | last4=Gerard  | first4=NP  | last5=Graham  | first5=GJ  | last6=Clark-Lewis  | first6=I  | last7=Gerard  | first7=C  }}
-*{{cite journal  | author=Bonini JA, Martin SK, Dralyuk F, ''et al.'' |title=Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. |journal=DNA Cell Biol. |volume=16 |issue= 10 |pages= 1249-56 |year= 1997 |pmid= 9364936 |doi=  }}
+*{{cite journal  | author=Homey B |title=Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC) |journal=J. Immunol. |volume=164 |issue= 7 |pages= 3465–70 |year= 2000 |pmid= 10725697 |doi=  10.4049/jimmunol.164.7.3465|name-list-format=vanc| author2=Wang W  | author3=Soto H  | display-authors=3  | last4=Buchanan  | first4=ME  | last5=Wiesenborn  | first5=A  | last6=Catron  | first6=D  | last7=Müller  | first7=A  | last8=McClanahan  | first8=TK  | last9=Dieu-Nosjean  | first9=MC  }}
-*{{cite journal  | author=Gosling J, Dairaghi DJ, Wang Y, ''et al.'' |title=Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. |journal=J. Immunol. |volume=164 |issue= 6 |pages= 2851-6 |year= 2000 |pmid= 10706668 |doi=  }}
+*{{cite journal  | author=Wang W |title=Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2) |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22313–23 |year= 2000 |pmid= 10781587 |doi= 10.1074/jbc.M001461200  |name-list-format=vanc| author2=Soto H  | author3=Oldham ER  | display-authors=3  | last4=Buchanan  | first4=ME  | last5=Homey  | first5=B  | last6=Catron  | first6=D  | last7=Jenkins  | first7=N  | last8=Copeland  | first8=NG  | last9=Gilbert  | first9=DJ }}
-*{{cite journal  | author=Jarmin DI, Rits M, Bota D, ''et al.'' |title=Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. |journal=J. Immunol. |volume=164 |issue= 7 |pages= 3460-4 |year= 2000 |pmid= 10725696 |doi=  }}
+*{{cite journal  | author=Pan J |title=A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues |journal=J. Immunol. |volume=165 |issue= 6 |pages= 2943–9 |year= 2000 |pmid= 10975800 |doi=  10.4049/jimmunol.165.6.2943|name-list-format=vanc| author2=Kunkel EJ  | author3=Gosslar U  | display-authors=3  | last4=Lazarus  | first4=N  | last5=Langdon  | first5=P  | last6=Broadwell  | first6=K  | last7=Vierra  | first7=MA  | last8=Genovese  | first8=MC  | last9=Butcher  | first9=EC  }}
-*{{cite journal  | author=Homey B, Wang W, Soto H, ''et al.'' |title=Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). |journal=J. Immunol. |volume=164 |issue= 7 |pages= 3465-70 |year= 2000 |pmid= 10725697 |doi=  }}
+*{{cite journal  |vauthors=Patel L, Charlton SJ, Chambers JK, Macphee CH |title=Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations |journal=Cytokine |volume=14 |issue= 1 |pages= 27–36 |year= 2001 |pmid= 11298490 |doi= 10.1006/cyto.2000.0851 }}
-*{{cite journal  | author=Wang W, Soto H, Oldham ER, ''et al.'' |title=Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22313-23 |year= 2000 |pmid= 10781587 |doi= 10.1074/jbc.M001461200 }}
+*{{cite journal  | author=Homey B |title=CCL27-CCR10 interactions regulate T cell-mediated skin inflammation |journal=Nat. Med. |volume=8 |issue= 2 |pages= 157–65 |year= 2002 |pmid= 11821900 |doi= 10.1038/nm0202-157  |name-list-format=vanc| author2=Alenius H  | author3=Müller A  | display-authors=3  | last4=Soto  | first4=Hortensia  | last5=Bowman  | first5=Edward P.  | last6=Yuan  | first6=Wei  | last7=McEvoy  | first7=Leslie  | last8=Lauerma  | first8=Antti I.  | last9=Assmann  | first9=Till }}
-*{{cite journal  | author=Pan J, Kunkel EJ, Gosslar U, ''et al.'' |title=A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. |journal=J. Immunol. |volume=165 |issue= 6 |pages= 2943-9 |year= 2000 |pmid= 10975800 |doi=  }}
+*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
-*{{cite journal  | author=Patel L, Charlton SJ, Chambers JK, Macphee CH |title=Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations. |journal=Cytokine |volume=14 |issue= 1 |pages= 27-36 |year= 2001 |pmid= 11298490 |doi= 10.1006/cyto.2000.0851 }}
+*{{cite journal  | author=Lehner B |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0  |name-list-format=vanc| author2=Semple JI  | author3=Brown SE  | display-authors=3  | last4=Counsell  | first4=Damian  | last5=Campbell  | first5=R.Duncan  | last6=Sanderson  | first6=Christopher M  }}
-*{{cite journal  | author=Homey B, Alenius H, Müller A, ''et al.'' |title=CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. |journal=Nat. Med. |volume=8 |issue= 2 |pages= 157-65 |year= 2002 |pmid= 11821900 |doi= 10.1038/nm0202-157 }}
+*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | author=Notohamiprodjo M |title=CCR10 is expressed in cutaneous T-cell lymphoma |journal=Int. J. Cancer |volume=115 |issue= 4 |pages= 641–7 |year= 2005 |pmid= 15700309 |doi= 10.1002/ijc.20922  |name-list-format=vanc| author2=Segerer S  | author3=Huss R  | display-authors=3  | last4=Hildebrandt  | first4=Bernhard  | last5=Soler  | first5=Dulce  | last6=Djafarzadeh  | first6=Roghieh  | last7=Buck  | first7=Wiebke  | last8=Nelson  | first8=Peter J.  | last9=Von Luettichau  | first9=Irene }}
-*{{cite journal  | author=Lehner B, Semple JI, Brown SE, ''et al.'' |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153-67 |year= 2004 |pmid= 14667819 |doi=  }}
+*{{cite journal  | author=Rodrigues-Lisoni FC |title=In vitro and in vivo studies on CCR10 regulation by Annexin A1 |journal=FEBS Lett. |volume=580 |issue= 5 |pages= 1431–8 |year= 2006 |pmid= 16460738 |doi= 10.1016/j.febslet.2006.01.072  |name-list-format=vanc| author2=Mehet DK  | author3=Mehemet DK  | display-authors=3  | last4=John  | first4=C  | last5=Tajara  | first5=E  | last6=Buckingham  | first6=J  | last7=Solito  | first7=E  | last8=Solito  | first8=E }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  | author=Fujita Y |title=Presence of circulating CCR10+ T cells and elevated serum CTACK/CCL27 in the early stage of mycosis fungoides |journal=Clin. Cancer Res. |volume=12 |issue= 9 |pages= 2670–5 |year= 2006 |pmid= 16675558 |doi= 10.1158/1078-0432.CCR-05-1513  |name-list-format=vanc| author2=Abe R  | author3=Sasaki M  | display-authors=3  | last4=Honda  | first4=A  | last5=Furuichi  | first5=M  | last6=Asano  | first6=Y  | last7=Norisugi  | first7=O  | last8=Shimizu  | first8=T  | last9=Shimizu  | first9=H }}
-*{{cite journal  | author=Notohamiprodjo M, Segerer S, Huss R, ''et al.'' |title=CCR10 is expressed in cutaneous T-cell lymphoma. |journal=Int. J. Cancer |volume=115 |issue= 4 |pages= 641-7 |year= 2005 |pmid= 15700309 |doi= 10.1002/ijc.20922 }}
+*{{cite journal  | author=Eksteen B |title=Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10 |journal=J. Immunol. |volume=177 |issue= 1 |pages= 593–603 |year= 2006 |pmid= 16785557 |doi=  10.4049/jimmunol.177.1.593|name-list-format=vanc| author2=Miles A  | author3=Curbishley SM  | display-authors=3  | last4=Tselepis  | first4=C  | last5=Grant  | first5=AJ  | last6=Walker  | first6=LS  | last7=Adams  | first7=DH  }}
-*{{cite journal  | author=Rodrigues-Lisoni FC, Mehet DK, Mehemet DK, ''et al.'' |title=In vitro and in vivo studies on CCR10 regulation by Annexin A1. |journal=FEBS Lett. |volume=580 |issue= 5 |pages= 1431-8 |year= 2006 |pmid= 16460738 |doi= 10.1016/j.febslet.2006.01.072 }}
+*{{cite journal  | author=Harasawa H |title=Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphoma |journal=Leuk. Lymphoma |volume=47 |issue= 10 |pages= 2163–73 |year= 2007 |pmid= 17071491 |doi= 10.1080/10428190600775599  |name-list-format=vanc| author2=Yamada Y  | author3=Hieshima K  | display-authors=3  | last4=Jin  | first4=Zhe  | last5=Nakayama  | first5=Takashi  | last6=Yoshie  | first6=Osamu  | last7=Shimizu  | first7=Kazuhiro  | last8=Hasegawa  | first8=Hiroo  | last9=Hayashi  | first9=Tomayoshi }}
-*{{cite journal  | author=Fujita Y, Abe R, Sasaki M, ''et al.'' |title=Presence of circulating CCR10+ T cells and elevated serum CTACK/CCL27 in the early stage of mycosis fungoides. |journal=Clin. Cancer Res. |volume=12 |issue= 9 |pages= 2670-5 |year= 2006 |pmid= 16675558 |doi= 10.1158/1078-0432.CCR-05-1513 }}
-*{{cite journal  | author=Eksteen B, Miles A, Curbishley SM, ''et al.'' |title=Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10. |journal=J. Immunol. |volume=177 |issue= 1 |pages= 593-603 |year= 2006 |pmid= 16785557 |doi=  }}
-*{{cite journal  | author=Harasawa H, Yamada Y, Hieshima K, ''et al.'' |title=Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphoma. |journal=Leuk. Lymphoma |volume=47 |issue= 10 |pages= 2163-73 |year= 2007 |pmid= 17071491 |doi= 10.1080/10428190600775599 }}
-}}
 {{refend}}
+==External links==
+* {{UCSC gene info|CCR10}}
+*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2238 | title = Chemokine Receptors: CCR10 | accessdate = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
 {{NLM content}}
-{{membrane-protein-stub}}
 {{Chemokine receptors}}
+{{Chemokine receptor modulators}}
 [[Category:Chemokine receptors]]
-{{WikiDoc Sources}}

CCR10: Difference between revisions

Latest revision as of 09:19, 30 August 2017

Contents

Function

References

Further reading

External links

Navigation menu