CCBP2: Difference between revisions

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{{Infobox_gene}}
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'''Chemokine-binding protein 2''' is a [[protein]] that in humans is encoded by the ''CCBP2'' [[gene]].<ref name="pmid9364936">{{cite journal | vauthors = Bonini JA, Martin SK, Dralyuk F, Roe MW, Philipson LH, Steiner DF | title = Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3 | journal = DNA Cell Biol | volume = 16 | issue = 10 | pages = 1249–56 |date=Dec 1997 | pmid = 9364936 | pmc =  | doi =10.1089/dna.1997.16.1249  }}</ref><ref name="pmid9405404">{{cite journal | vauthors = Nibbs RJ, Wylie SM, Yang J, Landau NR, Graham GJ | title = Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6 | journal = J Biol Chem | volume = 272 | issue = 51 | pages = 32078–83 |date=Jan 1998 | pmid = 9405404 | pmc =  | doi =10.1074/jbc.272.51.32078 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CCBP2 chemokine binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1238| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Chemokine binding protein 2
| HGNCid = 1565
| Symbol = CCBP2
| AltSymbols =; CCR10; CCR9; CMKBR9; D6; MGC126678; MGC138250; hD6
| OMIM = 602648
| ECnumber = 
| Homologene = 992
| MGIid = 1891697
| GeneAtlas_image1 = PBB_GE_CCBP2_206887_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016493 |text = C-C chemokine receptor activity}} {{GNF_GO|id=GO:0016494 |text = C-X-C chemokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
  | Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1238
    | Hs_Ensembl = ENSG00000144648
    | Hs_RefseqProtein = NP_001287
    | Hs_RefseqmRNA = NM_001296
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 42836115
    | Hs_GenLoc_end = 42883778
    | Hs_Uniprot = O00590
    | Mm_EntrezGene = 59289
    | Mm_Ensembl = ENSMUSG00000044534
    | Mm_RefseqmRNA = NM_021609
    | Mm_RefseqProtein = NP_067622
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 121747162
    | Mm_GenLoc_end = 121759762
    | Mm_Uniprot = Q2V6T2
  }}
}}
'''Chemokine binding protein 2''', also known as '''CCBP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCBP2 chemokine binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1238| accessdate = }}</ref>


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{{PBB_Summary
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| section_title =  
| summary_text = This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.<ref name="entrez">{{cite web | title = Entrez Gene: CCBP2 chemokine binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1238| accessdate = }}</ref>
| summary_text = This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ACKR2}}
* {{UCSC gene info|CCR10}}
* {{UCSC gene info|CCR9}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Nibbs RJ, Wylie SM, Pragnell IB, Graham GJ |title=Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. |journal=J. Biol. Chem. |volume=272 |issue= 19 |pages= 12495-504 |year= 1997 |pmid= 9139699 |doi=  }}
*{{cite journal  | vauthors=Nibbs RJ, Wylie SM, Pragnell IB, Graham GJ |title=Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. |journal=J. Biol. Chem. |volume=272 |issue= 19 |pages= 12495–504 |year= 1997 |pmid= 9139699 |doi=10.1074/jbc.272.19.12495 }}
*{{cite journal  | author=Bonini JA, Martin SK, Dralyuk F, ''et al.'' |title=Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. |journal=DNA Cell Biol. |volume=16 |issue= 10 |pages= 1249-56 |year= 1997 |pmid= 9364936 |doi=  }}
*{{cite journal  | vauthors=Nibbs RJ, Yang J, Landau NR |title=LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity. |journal=J. Biol. Chem. |volume=274 |issue= 25 |pages= 17478–83 |year= 1999 |pmid= 10364178 |doi=10.1074/jbc.274.25.17478 |display-authors=etal}}
*{{cite journal  | author=Nibbs RJ, Wylie SM, Yang J, ''et al.'' |title=Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32078-83 |year= 1998 |pmid= 9405404 |doi=  }}
*{{cite journal  | vauthors=Maho A, Bensimon A, Vassart G, Parmentier M |title=Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 265–8 |year= 2000 |pmid= 10702689 |doi=10.1159/000015443 }}
*{{cite journal  | author=Nibbs RJ, Yang J, Landau NR, ''et al.'' |title=LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity. |journal=J. Biol. Chem. |volume=274 |issue= 25 |pages= 17478-83 |year= 1999 |pmid= 10364178 |doi=  }}
*{{cite journal  | vauthors=Gosling J, Dairaghi DJ, Wang Y |title=Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. |journal=J. Immunol. |volume=164 |issue= 6 |pages= 2851–6 |year= 2000 |pmid= 10706668 |doi=  10.4049/jimmunol.164.6.2851|display-authors=etal}}
*{{cite journal  | author=Maho A, Bensimon A, Vassart G, Parmentier M |title=Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 265-8 |year= 2000 |pmid= 10702689 |doi=  }}
*{{cite journal  | vauthors=Jarmin DI, Rits M, Bota D |title=Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. |journal=J. Immunol. |volume=164 |issue= 7 |pages= 3460–4 |year= 2000 |pmid= 10725696 |doi=  10.4049/jimmunol.164.7.3460|display-authors=etal}}
*{{cite journal  | author=Gosling J, Dairaghi DJ, Wang Y, ''et al.'' |title=Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. |journal=J. Immunol. |volume=164 |issue= 6 |pages= 2851-6 |year= 2000 |pmid= 10706668 |doi=  }}
*{{cite journal  | vauthors=Homey B, Wang W, Soto H |title=Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). |journal=J. Immunol. |volume=164 |issue= 7 |pages= 3465–70 |year= 2000 |pmid= 10725697 |doi=  10.4049/jimmunol.164.7.3465|display-authors=etal}}
*{{cite journal  | author=Jarmin DI, Rits M, Bota D, ''et al.'' |title=Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. |journal=J. Immunol. |volume=164 |issue= 7 |pages= 3460-4 |year= 2000 |pmid= 10725696 |doi= }}
*{{cite journal  | vauthors=Wang W, Soto H, Oldham ER |title=Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22313–23 |year= 2000 |pmid= 10781587 |doi= 10.1074/jbc.M001461200 |display-authors=etal}}
*{{cite journal  | author=Homey B, Wang W, Soto H, ''et al.'' |title=Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). |journal=J. Immunol. |volume=164 |issue= 7 |pages= 3465-70 |year= 2000 |pmid= 10725697 |doi=  }}
*{{cite journal  | vauthors=Nibbs RJ, Kriehuber E, Ponath PD |title=The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors. |journal=Am. J. Pathol. |volume=158 |issue= 3 |pages= 867–77 |year= 2001 |pmid= 11238036 |doi=  10.1016/s0002-9440(10)64035-7| pmc=1850343  |display-authors=etal}}
*{{cite journal  | author=Wang W, Soto H, Oldham ER, ''et al.'' |title=Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22313-23 |year= 2000 |pmid= 10781587 |doi= 10.1074/jbc.M001461200 }}
*{{cite journal  | vauthors=Homey B, Alenius H, Müller A |title=CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. |journal=Nat. Med. |volume=8 |issue= 2 |pages= 157–65 |year= 2002 |pmid= 11821900 |doi= 10.1038/nm0202-157 |display-authors=etal}}
*{{cite journal  | author=Nibbs RJ, Kriehuber E, Ponath PD, ''et al.'' |title=The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors. |journal=Am. J. Pathol. |volume=158 |issue= 3 |pages= 867-77 |year= 2001 |pmid= 11238036 |doi= }}
*{{cite journal  | vauthors=Soler D, Humphreys TL, Spinola SM, Campbell JJ |title=CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking. |journal=Blood |volume=101 |issue= 5 |pages= 1677–82 |year= 2003 |pmid= 12406880 |doi= 10.1182/blood-2002-07-2348 }}
*{{cite journal  | author=Homey B, Alenius H, Müller A, ''et al.'' |title=CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. |journal=Nat. Med. |volume=8 |issue= 2 |pages= 157-65 |year= 2002 |pmid= 11821900 |doi= 10.1038/nm0202-157 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Soler D, Humphreys TL, Spinola SM, Campbell JJ |title=CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking. |journal=Blood |volume=101 |issue= 5 |pages= 1677-82 |year= 2003 |pmid= 12406880 |doi= 10.1182/blood-2002-07-2348 }}
*{{cite journal  | vauthors=Fra AM, Locati M, Otero K |title=Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6. |journal=J. Immunol. |volume=170 |issue= 5 |pages= 2279–82 |year= 2003 |pmid= 12594248 |doi= 10.4049/jimmunol.170.5.2279|display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Kunkel EJ, Kim CH, Lazarus NH |title=CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. |journal=J. Clin. Invest. |volume=111 |issue= 7 |pages= 1001–10 |year= 2003 |pmid= 12671049 |doi=10.1172/JCI17244  | pmc=152588  |display-authors=etal}}
*{{cite journal  | author=Fra AM, Locati M, Otero K, ''et al.'' |title=Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6. |journal=J. Immunol. |volume=170 |issue= 5 |pages= 2279-82 |year= 2003 |pmid= 12594248 |doi= }}
*{{cite journal  | vauthors=Galliera E, Jala VR, Trent JO |title=beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6. |journal=J. Biol. Chem. |volume=279 |issue= 24 |pages= 25590–7 |year= 2004 |pmid= 15084596 |doi= 10.1074/jbc.M400363200 |display-authors=etal}}
*{{cite journal  | author=Kunkel EJ, Kim CH, Lazarus NH, ''et al.'' |title=CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. |journal=J. Clin. Invest. |volume=111 |issue= 7 |pages= 1001-10 |year= 2003 |pmid= 12671049 |doi= }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Galliera E, Jala VR, Trent JO, ''et al.'' |title=beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6. |journal=J. Biol. Chem. |volume=279 |issue= 24 |pages= 25590-7 |year= 2004 |pmid= 15084596 |doi= 10.1074/jbc.M400363200 }}
*{{cite journal  | vauthors=Neil SJ, Aasa-Chapman MM, Clapham PR |title=The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes. |journal=J. Virol. |volume=79 |issue= 15 |pages= 9618–24 |year= 2005 |pmid= 16014924 |doi= 10.1128/JVI.79.15.9618-9624.2005  | pmc=1181543 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Neil SJ, Aasa-Chapman MM, Clapham PR, ''et al.'' |title=The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes. |journal=J. Virol. |volume=79 |issue= 15 |pages= 9618-24 |year= 2005 |pmid= 16014924 |doi= 10.1128/JVI.79.15.9618-9624.2005 }}
*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
{{Chemokine receptors}}
{{Chemokine receptors}}
{{Chemokine receptor modulators}}
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[[Category:Chemokine receptors]]
[[Category:Chemokine receptors]]
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{{transmembranereceptor-stub}}

Latest revision as of 09:20, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.[1][2][3]

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.[3]

References

  1. ↑ Bonini JA, Martin SK, Dralyuk F, Roe MW, Philipson LH, Steiner DF (Dec 1997). "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3". DNA Cell Biol. 16 (10): 1249–56. doi:10.1089/dna.1997.16.1249. PMID 9364936.
  2. ↑ Nibbs RJ, Wylie SM, Yang J, Landau NR, Graham GJ (Jan 1998). "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6". J Biol Chem. 272 (51): 32078–83. doi:10.1074/jbc.272.51.32078. PMID 9405404.
  3. ↑ 3.0 3.1 "Entrez Gene: CCBP2 chemokine binding protein 2".

External links

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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