IRAK3: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''Interleukin-1 receptor-associated kinase 3''' is an [[enzyme]] that in humans is encoded by the ''IRAK3'' [[gene]].<ref name="pmid10383454">{{cite journal |vauthors=Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z | title = IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family | journal = J Biol Chem | volume = 274 | issue = 27 | pages = 19403–10 |date=Jul 1999 | pmid = 10383454 | pmc =  | doi =10.1074/jbc.274.27.19403 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IRAK3 interleukin-1 receptor-associated kinase 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11213| accessdate = }}</ref>
'''Interleukin-1 receptor-associated kinase 3''' is an [[enzyme]] that in humans is encoded by the ''IRAK3'' [[gene]].<ref name="pmid10383454">{{cite journal | vauthors = Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z | title = IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family | journal = The Journal of Biological Chemistry | volume = 274 | issue = 27 | pages = 19403–10 | date = July 1999 | pmid = 10383454 | pmc =  | doi = 10.1074/jbc.274.27.19403 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IRAK3 interleukin-1 receptor-associated kinase 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11213| access-date = }}</ref> Using ''in vivo'' liposome-mediated delivery of CRISPR/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was shown to be responsible for endotoxin-induced expression of A20 and [[VE-cadherin]] in [[endothelial cells]]. Thus, IRAK3 is crucial for maintenance and repair of endothelial barrier after endotoxin-induced lung injury.<ref name="Soni_2018">{{cite journal | vauthors = Soni D, Wang DM, Regmi SC, Mittal M, Vogel SM, Schlüter D, Tiruppathi C | title = Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury | journal = Cell Death Discovery | volume = 4 | issue = 60 | pages = | date = May 2018 | pmid = | pmc = | doi = 10.1038/s41420-018-0056-3}}</ref>


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==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Rosati O, Martin MU | title = Identification and characterization of murine IRAK-M | journal = Biochemical and Biophysical Research Communications | volume = 293 | issue = 5 | pages = 1472–7 | date = May 2002 | pmid = 12054681 | doi = 10.1016/S0006-291X(02)00411-4 }}
| citations =
* {{cite journal | vauthors = Bin LH, Xu LG, Shu HB | title = TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling | journal = The Journal of Biological Chemistry | volume = 278 | issue = 27 | pages = 24526–32 | date = July 2003 | pmid = 12721283 | doi = 10.1074/jbc.M303451200 }}
*{{cite journal |vauthors=Rosati O, Martin MU |title=Identification and characterization of murine IRAK-M. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 5 |pages= 1472–7 |year= 2002 |pmid= 12054681 |doi= 10.1016/S0006-291X(02)00411-4 }}
* {{cite journal | vauthors = Escoll P, del Fresno C, García L, Vallés G, Lendínez MJ, Arnalich F, López-Collazo E | title = Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients | journal = Biochemical and Biophysical Research Communications | volume = 311 | issue = 2 | pages = 465–72 | date = November 2003 | pmid = 14592437 | doi = 10.1016/j.bbrc.2003.10.019 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
* {{cite journal | vauthors = del Fresno C, Otero K, Gómez-García L, González-León MC, Soler-Ranger L, Fuentes-Prior P, Escoll P, Baos R, Caveda L, García F, Arnalich F, López-Collazo E | title = Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4 | journal = Journal of Immunology | volume = 174 | issue = 5 | pages = 3032–40 | date = March 2005 | pmid = 15728517 | doi = 10.4049/jimmunol.174.5.3032 }}
*{{cite journal  |vauthors=Bin LH, Xu LG, Shu HB |title=TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling |journal=J. Biol. Chem. |volume=278 |issue= 27 |pages= 24526–32 |year= 2003 |pmid= 12721283 |doi= 10.1074/jbc.M303451200 }}
* {{cite journal | vauthors = Su J, Xie Q, Wilson I, Li L | title = Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling | journal = Cellular Signalling | volume = 19 | issue = 7 | pages = 1596–601 | date = July 2007 | pmid = 17379480 | pmc = 1978187 | doi = 10.1016/j.cellsig.2007.02.009 }}
*{{cite journal   |vauthors=Escoll P, del Fresno C, García L, etal |title=Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients |journal=Biochem. Biophys. Res. Commun. |volume=311 |issue= 2 |pages= 465–72 |year= 2004 |pmid= 14592437 |doi=10.1016/j.bbrc.2003.10.019 }}
* {{cite journal | vauthors = Balaci L, Spada MC, Olla N, Sole G, Loddo L, Anedda F, Naitza S, Zuncheddu MA, Maschio A, Altea D, Uda M, Pilia S, Sanna S, Masala M, Crisponi L, Fattori M, Devoto M, Doratiotto S, Rassu S, Mereu S, Giua E, Cadeddu NG, Atzeni R, Pelosi U, Corrias A, Perra R, Torrazza PL, Pirina P, Ginesu F, Marcias S, Schintu MG, Del Giacco GS, Manconi PE, Malerba G, Bisognin A, Trabetti E, Boner A, Pescollderungg L, Pignatti PF, Schlessinger D, Cao A, Pilia G | title = IRAK-M is involved in the pathogenesis of early-onset persistent asthma | journal = American Journal of Human Genetics | volume = 80 | issue = 6 | pages = 1103–14 | date = June 2007 | pmid = 17503328 | pmc = 1867098 | doi = 10.1086/518259 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
* {{cite journal | vauthors = Weersma RK, Oostenbrug LE, Nolte IM, Van Der Steege G, Oosterom E, Van Dullemen HM, Kleibeuker JH, Dijkstra G | title = Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases | journal = Scandinavian Journal of Gastroenterology | volume = 42 | issue = 7 | pages = 827–33 | date = July 2007 | pmid = 17558906 | doi = 10.1080/00365520601114024 }}
*{{cite journal  |vauthors=del Fresno C, Otero K, Gómez-García L, etal |title=Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4 |journal=J. Immunol. |volume=174 |issue= 5 |pages= 3032–40 |year= 2005 |pmid= 15728517 |doi= 10.4049/jimmunol.174.5.3032}}
* {{cite journal | vauthors = van 't Veer C, van den Pangaart PS, van Zoelen MA, de Kruif M, Birjmohun RS, Stroes ES, de Vos AF, van der Poll T | title = Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model | journal = Journal of Immunology | volume = 179 | issue = 10 | pages = 7110–20 | date = November 2007 | pmid = 17982103 | doi = 10.4049/jimmunol.179.10.7110 }}
*{{cite journal |vauthors=Su J, Xie Q, Wilson I, Li L |title=Differential regulation and role of Interleukin-1 Receptor Associated Kinase-M in innate immunity signaling |journal=Cell. Signal. |volume=19 |issue= 7 |pages= 1596–601 |year= 2007 |pmid= 17379480 |doi= 10.1016/j.cellsig.2007.02.009 | pmc=1978187 }}
*{{cite journal   |vauthors=Balaci L, Spada MC, Olla N, etal |title=IRAK-M Is Involved in the Pathogenesis of Early-Onset Persistent Asthma |journal=Am. J. Hum. Genet. |volume=80 |issue= 6 |pages= 1103–14 |year= 2007 |pmid= 17503328 |doi= 10.1086/518259 | pmc=1867098 }}
*{{cite journal   |vauthors=Weersma RK, Oostenbrug LE, Nolte IM, etal |title=Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases |journal=Scand. J. Gastroenterol. |volume=42 |issue= 7 |pages= 827–33 |year= 2007 |pmid= 17558906 |doi= 10.1080/00365520601114024 }}
*{{cite journal   |vauthors=van 't Veer C, van den Pangaart PS, van Zoelen MA, etal |title=Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model |journal=J. Immunol. |volume=179 |issue= 10 |pages= 7110–20 |year= 2007 |pmid= 17982103 |doi= 10.4049/jimmunol.179.10.7110}}
}}
{{refend}}
{{refend}}


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[[Category:EC 2.7.11]]
[[Category:EC 2.7.11]]


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Latest revision as of 03:36, 21 May 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Interleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the IRAK3 gene.[1][2] Using in vivo liposome-mediated delivery of CRISPR/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was shown to be responsible for endotoxin-induced expression of A20 and VE-cadherin in endothelial cells. Thus, IRAK3 is crucial for maintenance and repair of endothelial barrier after endotoxin-induced lung injury.[3]


References

  1. ↑ Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (July 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
  2. ↑ "Entrez Gene: IRAK3 interleukin-1 receptor-associated kinase 3".
  3. ↑ Soni D, Wang DM, Regmi SC, Mittal M, Vogel SM, Schlüter D, Tiruppathi C (May 2018). "Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury". Cell Death Discovery. 4 (60). doi:10.1038/s41420-018-0056-3.

Further reading

  • Rosati O, Martin MU (May 2002). "Identification and characterization of murine IRAK-M". Biochemical and Biophysical Research Communications. 293 (5): 1472–7. doi:10.1016/S0006-291X(02)00411-4. PMID 12054681.
  • Bin LH, Xu LG, Shu HB (July 2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". The Journal of Biological Chemistry. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
  • Escoll P, del Fresno C, García L, Vallés G, Lendínez MJ, Arnalich F, López-Collazo E (November 2003). "Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients". Biochemical and Biophysical Research Communications. 311 (2): 465–72. doi:10.1016/j.bbrc.2003.10.019. PMID 14592437.
  • del Fresno C, Otero K, Gómez-García L, González-León MC, Soler-Ranger L, Fuentes-Prior P, Escoll P, Baos R, Caveda L, García F, Arnalich F, López-Collazo E (March 2005). "Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4". Journal of Immunology. 174 (5): 3032–40. doi:10.4049/jimmunol.174.5.3032. PMID 15728517.
  • Su J, Xie Q, Wilson I, Li L (July 2007). "Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling". Cellular Signalling. 19 (7): 1596–601. doi:10.1016/j.cellsig.2007.02.009. PMC 1978187. PMID 17379480.
  • Balaci L, Spada MC, Olla N, Sole G, Loddo L, Anedda F, Naitza S, Zuncheddu MA, Maschio A, Altea D, Uda M, Pilia S, Sanna S, Masala M, Crisponi L, Fattori M, Devoto M, Doratiotto S, Rassu S, Mereu S, Giua E, Cadeddu NG, Atzeni R, Pelosi U, Corrias A, Perra R, Torrazza PL, Pirina P, Ginesu F, Marcias S, Schintu MG, Del Giacco GS, Manconi PE, Malerba G, Bisognin A, Trabetti E, Boner A, Pescollderungg L, Pignatti PF, Schlessinger D, Cao A, Pilia G (June 2007). "IRAK-M is involved in the pathogenesis of early-onset persistent asthma". American Journal of Human Genetics. 80 (6): 1103–14. doi:10.1086/518259. PMC 1867098. PMID 17503328.
  • Weersma RK, Oostenbrug LE, Nolte IM, Van Der Steege G, Oosterom E, Van Dullemen HM, Kleibeuker JH, Dijkstra G (July 2007). "Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases". Scandinavian Journal of Gastroenterology. 42 (7): 827–33. doi:10.1080/00365520601114024. PMID 17558906.
  • van 't Veer C, van den Pangaart PS, van Zoelen MA, de Kruif M, Birjmohun RS, Stroes ES, de Vos AF, van der Poll T (November 2007). "Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model". Journal of Immunology. 179 (10): 7110–20. doi:10.4049/jimmunol.179.10.7110. PMID 17982103.
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