Macrophage colony-stimulating factor

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Colony stimulating factor 1 (macrophage)
PDB rendering based on 1hmc.
Identifiers
Symbol(s) CSF1; MCSF; MGC31930
External IDs OMIM: 120420 MGI: 1339753 Homologene: 7282
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 1435 12977
Ensembl ENSG00000184371 ENSMUSG00000014599
Uniprot P09603 Q3TDK0
Refseq NM_000757 (mRNA)
NP_000748 (protein) 		NM_007778 (mRNA)
NP_031804 (protein)
Location Chr 1: 110.25 - 110.28 Mb Chr 3: 107.87 - 107.89 Mb
Pubmed search [1] [2]

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Overview

Macrophage colony-stimulating factor, or M-CSF, is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. (See colony-stimulating factor.) M-CSF binds to the macrophage colony-stimulating factor receptor. It may also be involved in development of the placenta.[1]

Structure

It is a cytokine. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors.[1]

Four transcript variants encoding three different isoforms have been found for this gene. [1]

References

Further reading

  • Stanley ER, Berg KL, Einstein DB, et al. (1995). "The biology and action of colony stimulating factor-1.". Stem Cells 12 Suppl 1: 15-24; discussion 25. PMID 7696959.
  • Alterman RL, Stanley ER (1994). "Colony stimulating factor-1 expression in human glioma.". Mol. Chem. Neuropathol. 21 (2-3): 177-88. PMID 8086034.
  • Stanley ER, Berg KL, Einstein DB, et al. (1997). "Biology and action of colony--stimulating factor-1.". Mol. Reprod. Dev. 46 (1): 4-10. doi:<4::AID-MRD2>3.0.CO;2-V 10.1002/(SICI)1098-2795(199701)46:1<4::AID-MRD2>3.0.CO;2-V. PMID 8981357.
  • Sweet MJ, Hume DA (2004). "CSF-1 as a regulator of macrophage activation and immune responses.". Arch. Immunol. Ther. Exp. (Warsz.) 51 (3): 169-77. PMID 12894871.
  • Mroczko B, Szmitkowski M (2005). "Hematopoietic cytokines as tumor markers.". Clin. Chem. Lab. Med. 42 (12): 1347-54. doi:10.1515/CCLM.2004.253. PMID 15576295.
  • Pandit J, Bohm A, Jancarik J, et al. (1993). "Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor.". Science 258 (5086): 1358-62. PMID 1455231.
  • Suzu S, Ohtsuki T, Yanai N, et al. (1992). "Identification of a high molecular weight macrophage colony-stimulating factor as a glycosaminoglycan-containing species.". J. Biol. Chem. 267 (7): 4345-8. PMID 1531650.
  • Saltman DL, Dolganov GM, Hinton LM, Lovett M (1992). "Reassignment of the human macrophage colony stimulating factor gene to chromosome 1p13-21.". Biochem. Biophys. Res. Commun. 182 (3): 1139-43. PMID 1540160.
  • Praloran V, Chevalier S, Gascan H (1992). "Macrophage colony-stimulating factor is produced by activated T lymphocytes in vitro and is detected in vivo in T cells from reactive lymph nodes.". Blood 79 (9): 2500-1. PMID 1571567.
  • Price LK, Choi HU, Rosenberg L, Stanley ER (1992). "The predominant form of secreted colony stimulating factor-1 is a proteoglycan.". J. Biol. Chem. 267 (4): 2190-9. PMID 1733926.
  • Pampfer S, Tabibzadeh S, Chuan FC, Pollard JW (1992). "Expression of colony-stimulating factor-1 (CSF-1) messenger RNA in human endometrial glands during the menstrual cycle: molecular cloning of a novel transcript that predicts a cell surface form of CSF-1.". Mol. Endocrinol. 5 (12): 1931-8. PMID 1791839.
  • Stein J, Borzillo GV, Rettenmier CW (1990). "Direct stimulation of cells expressing receptors for macrophage colony-stimulating factor (CSF-1) by a plasma membrane-bound precursor of human CSF-1.". Blood 76 (7): 1308-14. PMID 2145044.
  • Sherr CJ, Rettenmier CW, Sacca R, et al. (1985). "The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1.". Cell 41 (3): 665-76. PMID 2408759.
  • Cerretti DP, Wignall J, Anderson D, et al. (1988). "Human macrophage-colony stimulating factor: alternative RNA and protein processing from a single gene.". Mol. Immunol. 25 (8): 761-70. PMID 2460758.
  • Takahashi M, Hirato T, Takano M, et al. (1989). "Amino-terminal region of human macrophage colony-stimulating factor (M-CSF) is sufficient for its in vitro biological activity: molecular cloning and expression of carboxyl-terminal deletion mutants of human M-CSF.". Biochem. Biophys. Res. Commun. 161 (2): 892-901. PMID 2660794.
  • Kawasaki ES, Ladner MB, Wang AM, et al. (1985). "Molecular cloning of a complementary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1).". Science 230 (4723): 291-6. PMID 2996129.
  • Rettenmier CW, Roussel MF, Ashmun RA, et al. (1987). "Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes.". Mol. Cell. Biol. 7 (7): 2378-87. PMID 3039346.
  • Takahashi M, Hong YM, Yasuda S, et al. (1988). "Macrophage colony-stimulating factor is produced by human T lymphoblastoid cell line, CEM-ON: identification by amino-terminal amino acid sequence analysis.". Biochem. Biophys. Res. Commun. 152 (3): 1401-9. PMID 3259875.
  • Rettenmier CW, Roussel MF (1989). "Differential processing of colony-stimulating factor 1 precursors encoded by two human cDNAs.". Mol. Cell. Biol. 8 (11): 5026-34. PMID 3264877.
  • Wong GG, Temple PA, Leary AC, et al. (1987). "Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein.". Science 235 (4795): 1504-8. PMID 3493529.

External links


v • d • e
Cytokines, glycoproteins: colony-stimulating factors
NumberedMacrophage colony-stimulating factor - Granulocyte macrophage colony-stimulating factor - Granulocyte colony-stimulating factor
UnnumberedErythropoietin - Thrombopoietin - Interleukin 3
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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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