RPS6KA5: Difference between revisions

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Revision as of 09:28, 10 September 2017

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene.^[1]^[2]^[3]

Interactions

RPS6KA5 has been shown to interact with CREB1.^[1]^[4]

References

↑ ^1.0 ^1.1 Deak M, Clifton AD, Lucocq LM, Alessi DR (September 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.
↑ Jiang C, Yu L, Tu Q, Zhao Y, Zhang H, Zhao S (April 2000). "Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31→q32.1 by radiation hybrid mapping". Cytogenet Cell Genet. 87 (3–4): 261–2. doi:10.1159/000015441. PMID 10702687.
↑ "Entrez Gene: RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5".
↑ Wang, X; Li W; Williams M; Terada N; Alessi D R; Proud C G (August 2001). "Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase". EMBO J. England. 20 (16): 4370–9. doi:10.1093/emboj/20.16.4370. ISSN 0261-4189. PMC 125559. PMID 11500364.

Chung J, Uchida E, Grammer TC, Blenis J (1997). "STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation". Mol. Cell. Biol. 17 (11): 6508–16. PMC 232504. PMID 9343414.
Jain N, Zhang T, Fong SL, et al. (1999). "Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)". Oncogene. 17 (24): 3157–67. doi:10.1038/sj.onc.1202238. PMID 9872331.
New L, Zhao M, Li Y, et al. (1999). "Cloning and characterization of RLPK, a novel RSK-related protein kinase". J. Biol. Chem. 274 (2): 1026–32. doi:10.1074/jbc.274.2.1026. PMID 9873047.
Thomson S, Clayton AL, Hazzalin CA, et al. (1999). "The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase". EMBO J. 18 (17): 4779–93. doi:10.1093/emboj/18.17.4779. PMC 1171550. PMID 10469656.
Lim CP, Cao X (1999). "Serine phosphorylation and negative regulation of Stat3 by JNK". J. Biol. Chem. 274 (43): 31055–61. doi:10.1074/jbc.274.43.31055. PMID 10521505.
Buck M, Poli V, van der Geer P, et al. (2000). "Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha". Mol. Cell. 4 (6): 1087–92. doi:10.1016/S1097-2765(00)80237-3. PMID 10635333.
Lizcano JM, Morrice N, Cohen P (2001). "Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155". Biochem. J. 349 (Pt 2): 547–57. doi:10.1042/0264-6021:3490547. PMC 1221178. PMID 10880354.
Hefner Y, Borsch-Haubold AG, Murakami M, et al. (2001). "Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases". J. Biol. Chem. 275 (48): 37542–51. doi:10.1074/jbc.M003395200. PMID 10978317.
Arthur JS, Cohen P (2000). "MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells". FEBS Lett. 482 (1–2): 44–8. doi:10.1016/S0014-5793(00)02031-7. PMID 11018520.
Sapkota GP, Kieloch A, Lizcano JM, et al. (2001). "Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth". J. Biol. Chem. 276 (22): 19469–82. doi:10.1074/jbc.M009953200. PMID 11297520.
Deb A, Zamanian-Daryoush M, Xu Z, et al. (2001). "Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3". EMBO J. 20 (10): 2487–96. doi:10.1093/emboj/20.10.2487. PMC 125453. PMID 11350938.
Liu G, Zhang Y, Bode AM, et al. (2002). "Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation". J. Biol. Chem. 277 (11): 8810–6. doi:10.1074/jbc.M110477200. PMID 11777913.
Wiggin GR, Soloaga A, Foster JM, et al. (2002). "MSK1 and MSK2 Are Required for the Mitogen- and Stress-Induced Phosphorylation of CREB and ATF1 in Fibroblasts". Mol. Cell. Biol. 22 (8): 2871–81. doi:10.1128/MCB.22.8.2871-2881.2002. PMC 133730. PMID 11909979.
Markou T, Lazou A (2002). "Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase". Biochem. J. 365 (Pt 3): 757–63. doi:10.1042/BJ20011828. PMC 1222733. PMID 11994045.
Toska K, Kleppe R, Armstrong CG, et al. (2002). "Regulation of tyrosine hydroxylase by stress-activated protein kinases". J. Neurochem. 83 (4): 775–83. doi:10.1046/j.1471-4159.2002.01172.x. PMID 12421349.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Janknecht R (2003). "Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)". Oncogene. 22 (5): 746–55. doi:10.1038/sj.onc.1206185. PMID 12569367.
Dolled-Filhart M, Camp RL, Kowalski DP, et al. (2003). "Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis". Clin. Cancer Res. 9 (2): 594–600. PMID 12576423.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[pmid9687510-1] 1.0 ^1.1 Deak M, Clifton AD, Lucocq LM, Alessi DR (September 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.

[pmid10702687-2] Jiang C, Yu L, Tu Q, Zhao Y, Zhang H, Zhao S (April 2000). "Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31→q32.1 by radiation hybrid mapping". Cytogenet Cell Genet. 87 (3–4): 261–2. doi:10.1159/000015441. PMID 10702687.

[entrez-3] "Entrez Gene: RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5".

[pmid11500364-4] Wang, X; Li W; Williams M; Terada N; Alessi D R; Proud C G (August 2001). "Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase". EMBO J. England. 20 (16): 4370–9. doi:10.1093/emboj/20.16.4370. ISSN 0261-4189. PMC 125559. PMID 11500364.

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[3]

[4]

@@ Line 1: / Line 1: @@
+{{Infobox_gene}}
+'''Ribosomal protein S6 kinase alpha-5''' is an [[enzyme]] that in humans is encoded by the ''RPS6KA5'' [[gene]].<ref name="pmid9687510">{{cite journal |vauthors=Deak M, Clifton AD, Lucocq LM, Alessi DR | title = Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB | journal = EMBO J | volume = 17 | issue = 15 | pages = 4426–41 |date=September 1998 | pmid = 9687510 | pmc = 1170775 | doi = 10.1093/emboj/17.15.4426 }}</ref><ref name="pmid10702687">{{cite journal |vauthors=Jiang C, Yu L, Tu Q, Zhao Y, Zhang H, Zhao S | title = Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31→q32.1 by radiation hybrid mapping | journal = Cytogenet Cell Genet | volume = 87 | issue = 3–4 | pages = 261–2 |date=April 2000 | pmid = 10702687 | pmc =  | doi =10.1159/000015441  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9252| accessdate = }}</ref>
+<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+{{PBB_Summary
+| section_title =
+| summary_text =
+}}
+==Interactions==
+RPS6KA5 has been shown to [[Protein-protein interaction|interact]] with [[CREB1]].<ref name=pmid9687510 /><ref name=pmid11500364>{{cite journal |last=Wang |first=X |authorlink= |author2=Li W |author3=Williams M |author4=Terada N |author5=Alessi D R |author6=Proud C G  |date=August 2001 |title=Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase |journal=EMBO J. |volume=20 |issue=16 |pages=4370–9 |publisher= |location = England| issn = 0261-4189| pmid = 11500364 |doi = 10.1093/emboj/20.16.4370 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=125559 }}</ref>
+==References==
+{{Reflist}}
+==Further reading==
+{{Refbegin | 2}}
+{{PBB_Further_reading
+| citations =
+*{{cite journal  |vauthors=Chung J, Uchida E, Grammer TC, Blenis J |title=STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation |journal=Mol. Cell. Biol. |volume=17 |issue= 11 |pages= 6508–16 |year= 1997 |pmid= 9343414 |doi=  | pmc=232504  }}
+*{{cite journal  | author=Jain N |title=Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK) |journal=Oncogene |volume=17 |issue= 24 |pages= 3157–67 |year= 1999 |pmid= 9872331 |doi= 10.1038/sj.onc.1202238  |name-list-format=vanc| author2=Zhang T  | author3=Fong SL  | display-authors=3  | last4=Lim  | first4=Cheh Peng  | last5=Cao  | first5=Xinmin }}
+*{{cite journal  | author=New L |title=Cloning and characterization of RLPK, a novel RSK-related protein kinase |journal=J. Biol. Chem. |volume=274 |issue= 2 |pages= 1026–32 |year= 1999 |pmid= 9873047 |doi=10.1074/jbc.274.2.1026  |name-list-format=vanc| author2=Zhao M  | author3=Li Y  | display-authors=3  | last4=Bassett  | first4=WW  | last5=Feng  | first5=Y  | last6=Ludwig  | first6=S  | last7=Padova  | first7=FD  | last8=Gram  | first8=H  | last9=Han  | first9=J  }}
+*{{cite journal  | author=Thomson S |title=The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase |journal=EMBO J. |volume=18 |issue= 17 |pages= 4779–93 |year= 1999 |pmid= 10469656 |doi= 10.1093/emboj/18.17.4779  | pmc=1171550  |name-list-format=vanc| author2=Clayton AL  | author3=Hazzalin CA  | display-authors=3  | last4=Rose  | first4=S  | last5=Barratt  | first5=MJ  | last6=Mahadevan  | first6=LC }}
+*{{cite journal  |vauthors=Lim CP, Cao X |title=Serine phosphorylation and negative regulation of Stat3 by JNK |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 31055–61 |year= 1999 |pmid= 10521505 |doi=10.1074/jbc.274.43.31055  }}
+*{{cite journal  | author=Buck M |title=Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha |journal=Mol. Cell |volume=4 |issue= 6 |pages= 1087–92 |year= 2000 |pmid= 10635333 |doi=10.1016/S1097-2765(00)80237-3  |name-list-format=vanc| author2=Poli V  | author3=van der Geer P  | display-authors=3  | last4=Chojkier  | first4=Mario  | last5=Hunter  | first5=Tony  }}
+*{{cite journal  |vauthors=Lizcano JM, Morrice N, Cohen P |title=Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155 |journal=Biochem. J. |volume=349 |issue= Pt 2 |pages= 547–57 |year= 2001 |pmid= 10880354 |doi=10.1042/0264-6021:3490547  | pmc=1221178  }}
+*{{cite journal  | author=Hefner Y |title=Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37542–51 |year= 2001 |pmid= 10978317 |doi= 10.1074/jbc.M003395200  |name-list-format=vanc| author2=Borsch-Haubold AG  | author3=Murakami M  | display-authors=3  | last4=Wilde  | first4=JI  | last5=Pasquet  | first5=S  | last6=Schieltz  | first6=D  | last7=Ghomashchi  | first7=F  | last8=Yates Jr  | first8=3rd  | last9=Armstrong  | first9=CG }}
+*{{cite journal  |vauthors=Arthur JS, Cohen P |title=MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells |journal=FEBS Lett. |volume=482 |issue= 1–2 |pages= 44–8 |year= 2000 |pmid= 11018520 |doi=10.1016/S0014-5793(00)02031-7  }}
+*{{cite journal  | author=Sapkota GP |title=Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19469–82 |year= 2001 |pmid= 11297520 |doi= 10.1074/jbc.M009953200  |name-list-format=vanc| author2=Kieloch A  | author3=Lizcano JM  | display-authors=3  | last4=Lain  | first4=S  | last5=Arthur  | first5=JS  | last6=Williams  | first6=MR  | last7=Morrice  | first7=N  | last8=Deak  | first8=M  | last9=Alessi  | first9=DR }}
+*{{cite journal  | author=Deb A |title=Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3 |journal=EMBO J. |volume=20 |issue= 10 |pages= 2487–96 |year= 2001 |pmid= 11350938 |doi= 10.1093/emboj/20.10.2487  | pmc=125453  |name-list-format=vanc| author2=Zamanian-Daryoush M  | author3=Xu Z  | display-authors=3  | last4=Kadereit  | first4=S  | last5=Williams  | first5=BR }}
+*{{cite journal  | author=Liu G |title=Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 8810–6 |year= 2002 |pmid= 11777913 |doi= 10.1074/jbc.M110477200  |name-list-format=vanc| author2=Zhang Y  | author3=Bode AM  | display-authors=3  | last4=Ma  | first4=WY  | last5=Dong  | first5=Z }}
+*{{cite journal  | author=Wiggin GR |title=MSK1 and MSK2 Are Required for the Mitogen- and Stress-Induced Phosphorylation of CREB and ATF1 in Fibroblasts |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2871–81 |year= 2002 |pmid= 11909979 |doi=10.1128/MCB.22.8.2871-2881.2002  | pmc=133730  |name-list-format=vanc| author2=Soloaga A  | author3=Foster JM  | display-authors=3  | last4=Murray-Tait  | first4=V.  | last5=Cohen  | first5=P.  | last6=Arthur  | first6=J. S. C.  }}
+*{{cite journal  |vauthors=Markou T, Lazou A |title=Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase |journal=Biochem. J. |volume=365 |issue= Pt 3 |pages= 757–63 |year= 2002 |pmid= 11994045 |doi= 10.1042/BJ20011828  | pmc=1222733 }}
+*{{cite journal  | author=Toska K |title=Regulation of tyrosine hydroxylase by stress-activated protein kinases |journal=J. Neurochem. |volume=83 |issue= 4 |pages= 775–83 |year= 2002 |pmid= 12421349 |doi=10.1046/j.1471-4159.2002.01172.x  |name-list-format=vanc| author2=Kleppe R  | author3=Armstrong CG  | display-authors=3  | last4=Morrice  | first4=Nick A.  | last5=Cohen  | first5=Philip  | last6=Haavik  | first6=Jan  }}
+*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
+*{{cite journal  | author=Janknecht R |title=Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1) |journal=Oncogene |volume=22 |issue= 5 |pages= 746–55 |year= 2003 |pmid= 12569367 |doi= 10.1038/sj.onc.1206185 }}
+*{{cite journal  | author=Dolled-Filhart M |title=Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis |journal=Clin. Cancer Res. |volume=9 |issue= 2 |pages= 594–600 |year= 2003 |pmid= 12576423 |doi=  |name-list-format=vanc| author2=Camp RL  | author3=Kowalski DP  | display-authors=3  | last4=Smith  | first4=BL  | last5=Rimm  | first5=DL  }}
+}}
+{{Refend}}
+{{PDB Gallery|geneid=9252}}
+{{Serine/threonine-specific protein kinases}}
+{{Enzymes}}
+{{Portal bar|Molecular and Cellular Biology|border=no}}
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+[[Category:EC 2.7.11]]
-{{GNF_Protein_box
- | image = PBB_Protein_RPS6KA5_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1vzo.
- | PDB = {{PDB2|1vzo}}
- | Name = Ribosomal protein S6 kinase, 90kDa, polypeptide 5
- | HGNCid = 10434
- | Symbol = RPS6KA5
- | AltSymbols =; MGC1911; MSK1; MSPK1; RLPK
- | OMIM = 603607
- | ECnumber =
- | Homologene = 48302
- | MGIid = 1920336
- | GeneAtlas_image1 = PBB_GE_RPS6KA5_204635_at_tn.png
- | GeneAtlas_image2 = PBB_GE_RPS6KA5_204633_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003824 |text = catalytic activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008237 |text = metallopeptidase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007173 |text = epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0009605 |text = response to external stimulus}} {{GNF_GO|id=GO:0016572 |text = histone phosphorylation}} {{GNF_GO|id=GO:0042221 |text = response to chemical stimulus}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 9252
-    | Hs_Ensembl = ENSG00000100784
-    | Hs_RefseqProtein = NP_004746
-    | Hs_RefseqmRNA = NM_004755
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 14
-    | Hs_GenLoc_start = 90406925
-    | Hs_GenLoc_end = 90596746
-    | Hs_Uniprot = O75582
-    | Mm_EntrezGene = 73086
-    | Mm_Ensembl = ENSMUSG00000021180
-    | Mm_RefseqmRNA = NM_153587
-    | Mm_RefseqProtein = NP_705815
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 12
-    | Mm_GenLoc_start = 100950828
-    | Mm_GenLoc_end = 101126078
-    | Mm_Uniprot = Q8C050
-  }}
-}}
-'''Ribosomal protein S6 kinase, 90kDa, polypeptide 5''', also known as '''RPS6KA5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9252| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==References==
-{{reflist|2}}
-==Further reading==
-{{refbegin | 2}}
-{{PBB_Further_reading
-| citations =
-*{{cite journal  | author=Chung J, Uchida E, Grammer TC, Blenis J |title=STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. |journal=Mol. Cell. Biol. |volume=17 |issue= 11 |pages= 6508-16 |year= 1997 |pmid= 9343414 |doi=  }}
-*{{cite journal  | author=Deak M, Clifton AD, Lucocq LM, Alessi DR |title=Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. |journal=EMBO J. |volume=17 |issue= 15 |pages= 4426-41 |year= 1998 |pmid= 9687510 |doi= 10.1093/emboj/17.15.4426 }}
-*{{cite journal  | author=Jain N, Zhang T, Fong SL, ''et al.'' |title=Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK). |journal=Oncogene |volume=17 |issue= 24 |pages= 3157-67 |year= 1999 |pmid= 9872331 |doi= 10.1038/sj.onc.1202238 }}
-*{{cite journal  | author=New L, Zhao M, Li Y, ''et al.'' |title=Cloning and characterization of RLPK, a novel RSK-related protein kinase. |journal=J. Biol. Chem. |volume=274 |issue= 2 |pages= 1026-32 |year= 1999 |pmid= 9873047 |doi=  }}
-*{{cite journal  | author=Thomson S, Clayton AL, Hazzalin CA, ''et al.'' |title=The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase. |journal=EMBO J. |volume=18 |issue= 17 |pages= 4779-93 |year= 1999 |pmid= 10469656 |doi= 10.1093/emboj/18.17.4779 }}
-*{{cite journal  | author=Lim CP, Cao X |title=Serine phosphorylation and negative regulation of Stat3 by JNK. |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 31055-61 |year= 1999 |pmid= 10521505 |doi=  }}
-*{{cite journal  | author=Buck M, Poli V, van der Geer P, ''et al.'' |title=Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha. |journal=Mol. Cell |volume=4 |issue= 6 |pages= 1087-92 |year= 2000 |pmid= 10635333 |doi=  }}
-*{{cite journal  | author=Jiang C, Yu L, Tu Q, ''et al.'' |title=Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31-->q32.1 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 261-2 |year= 2000 |pmid= 10702687 |doi=  }}
-*{{cite journal  | author=Lizcano JM, Morrice N, Cohen P |title=Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155. |journal=Biochem. J. |volume=349 |issue= Pt 2 |pages= 547-57 |year= 2001 |pmid= 10880354 |doi=  }}
-*{{cite journal  | author=Hefner Y, Borsch-Haubold AG, Murakami M, ''et al.'' |title=Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37542-51 |year= 2001 |pmid= 10978317 |doi= 10.1074/jbc.M003395200 }}
-*{{cite journal  | author=Arthur JS, Cohen P |title=MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells. |journal=FEBS Lett. |volume=482 |issue= 1-2 |pages= 44-8 |year= 2000 |pmid= 11018520 |doi=  }}
-*{{cite journal  | author=Sapkota GP, Kieloch A, Lizcano JM, ''et al.'' |title=Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19469-82 |year= 2001 |pmid= 11297520 |doi= 10.1074/jbc.M009953200 }}
-*{{cite journal  | author=Deb A, Zamanian-Daryoush M, Xu Z, ''et al.'' |title=Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3. |journal=EMBO J. |volume=20 |issue= 10 |pages= 2487-96 |year= 2001 |pmid= 11350938 |doi= 10.1093/emboj/20.10.2487 }}
-*{{cite journal  | author=Liu G, Zhang Y, Bode AM, ''et al.'' |title=Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 8810-6 |year= 2002 |pmid= 11777913 |doi= 10.1074/jbc.M110477200 }}
-*{{cite journal  | author=Wiggin GR, Soloaga A, Foster JM, ''et al.'' |title=MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2871-81 |year= 2002 |pmid= 11909979 |doi=  }}
-*{{cite journal  | author=Markou T, Lazou A |title=Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase. |journal=Biochem. J. |volume=365 |issue= Pt 3 |pages= 757-63 |year= 2002 |pmid= 11994045 |doi= 10.1042/BJ20011828 }}
-*{{cite journal  | author=Toska K, Kleppe R, Armstrong CG, ''et al.'' |title=Regulation of tyrosine hydroxylase by stress-activated protein kinases. |journal=J. Neurochem. |volume=83 |issue= 4 |pages= 775-83 |year= 2002 |pmid= 12421349 |doi=  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Janknecht R |title=Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1). |journal=Oncogene |volume=22 |issue= 5 |pages= 746-55 |year= 2003 |pmid= 12569367 |doi= 10.1038/sj.onc.1206185 }}
-*{{cite journal  | author=Dolled-Filhart M, Camp RL, Kowalski DP, ''et al.'' |title=Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis. |journal=Clin. Cancer Res. |volume=9 |issue= 2 |pages= 594-600 |year= 2003 |pmid= 12576423 |doi=  }}
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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

RPS6KA5: Difference between revisions

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