Potassium-sparing diuretic
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Please Join in Editing This Page and Apply to be an Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Potassium-sparing diuretic refers to diuretic drugs that do not promote the secretion of potassium into the urine. They are used as adjunctive therapy, together with other drugs, in the treatment of hypertension and management of congestive heart failure.
Mechanism of action
Potassium-sparing diuretics decrease sodium reabsorption at collecting tubules, inducing diuresis; decrease activity of aldosterone at collecting tubules.
Indications
Potassium-sparing diuretics are generally used in combination with other diuretic drugs (e.g. loop diuretics) that would otherwise tend to lower the potassium levels to potentially dangerous low levels (hypokalemia). The combination therefore helps maintain a normal reference range for potassium.
Side effects
On their own this group of drugs may raise potassium levels beyond the normal range, termed hyperkalemia, which risks potentially fatal arrhythmias.
Chemical structure
Potassium-sparing diuretics do not share any obvious chemical similarities, except for the steroid-structure of the aldosterone antagonists. Those in clinical use include:
See also
External links
References
- Block JH, Beale JM. "Organic Medicinal and Pharmaceutical Chemistry" 11th edition. Lippincott Williams & Wilkins. 2004.
Circulatory system pathology (I, 390-459) | |
|---|---|
| Hypertension | Hypertensive heart disease - Hypertensive nephropathy - Secondary hypertension (Renovascular hypertension) |
| Ischaemic heart disease | Angina pectoris (Prinzmetal's angina) - Myocardial infarction (heart attack) - Dressler's syndrome |
| Pulmonary circulation | Pulmonary embolism - Cor pulmonale |
| Pericardium | Pericarditis - Pericardial effusion - Cardiac tamponade |
| Endocardium/heart valves | Endocarditis - mitral valve (regurgitation, prolapse, stenosis) - aortic valve (stenosis, insufficiency) - pulmonary valve (stenosis, insufficiency) - tricuspid valve (stenosis, insufficiency) |
| Myocardium | Myocarditis - Cardiomyopathy (Dilated cardiomyopathy, Hypertrophic cardiomyopathy, Loeffler endocarditis, Restrictive cardiomyopathy) - Arrhythmogenic right ventricular dysplasia |
| Electrical conduction system of the heart | Heart block: AV block (First degree, Second degree, Third degree) - Bundle branch block (Left, Right) - Bifascicular block - Trifascicular block Pre-excitation syndrome (Wolff-Parkinson-White, Lown-Ganong-Levine) - Long QT syndrome - Adams-Stokes syndrome - Cardiac arrest - Sudden cardiac death Arrhythmia: Paroxysmal tachycardia (Supraventricular, AV nodal reentrant, Ventricular) - Atrial flutter - Atrial fibrillation (Familial) - Ventricular fibrillation - Premature contraction (Atrial, Ventricular) - Ectopic pacemaker - Sick sinus syndrome |
| Other heart conditions | Heart failure - Cardiovascular disease - Cardiomegaly - Ventricular hypertrophy (Left, Right) |
| Cerebrovascular diseases | Stroke - Transient ischemic attack - Intracranial hemorrhage/cerebral hemorrhage: Extra-axial hemorrhage (Epidural hemorrhage, Subdural hemorrhage, Subarachnoid hemorrhage) Intra-axial hematoma (Intraventricular hemorrhages, Intraparenchymal hemorrhage) - Anterior spinal artery syndrome - Binswanger's disease - Moyamoya disease |
| Arteries, arterioles and capillaries | Atherosclerosis (Renal artery stenosis) - Aortic dissection/Aortic aneurysm (Abdominal aortic aneurysm) - Aneurysm - Raynaud's phenomenon/Raynaud's disease - Buerger's disease - Vasculitis/Arteritis (Aortitis) - Intermittent claudication - Arteriovenous fistula - Hereditary hemorrhagic telangiectasia - Spider angioma - Dissection (Carotid artery, Vertebral artery) |
| Veins, lymphatic vessels and lymph nodes | Thrombosis/Phlebitis/Thrombophlebitis (Deep vein thrombosis, May-Thurner syndrome, Portal vein thrombosis, Venous thrombosis, Budd-Chiari syndrome, Renal vein thrombosis, Paget-Schroetter disease) - Varicose veins / Portacaval anastomosis (Hemorrhoid, Esophageal varices, Varicocele, Gastric varices, Caput medusae) - Superior vena cava syndrome - Lymph (Lymphadenitis, Lymphedema, Lymphangitis) |
| Other | Hypotension (Orthostatic hypotension) - Rheumatic fever |
| See also congenital (Q20-Q28, 745-747) | |
WikiDoc Research Resources for Potassium-sparing diuretic | |
|---|---|
| Articles on Potassium-sparing diuretic | Most recent articles on Potassium-sparing diuretic • Most cited articles on Potassium-sparing diuretic • Review articles on Potassium-sparing diuretic • Articles on Potassium-sparing diuretic in N Eng J Med, Lancet, BMJ |
| Media (Slides, Video, Images, MP3) on Potassium-sparing diuretic | Powerpoint slides on Potassium-sparing diuretic • Images of Potassium-sparing diuretic • Photos of Potassium-sparing diuretic • Podcasts & MP3s on Potassium-sparing diuretic • Videos on Potassium-sparing diuretic |
| Evidence Based Medicine Regarding Potassium-sparing diuretic | AND (Cochrane Database Syst Rev[http://worldselectshop.com/?id=9361 Cochrane Collaboration on Potassium-sparing diuretic • Bandolier on Potassium-sparing diuretic • TRIP on Potassium-sparing diuretic |
| Cost Effectiveness of Potassium-sparing diuretic | AND (Cost effectiveness) |
| group5 = Clinical Trials Involving Potassium-sparing diuretic | list5 = Ongoing Trials on Potassium-sparing diuretic at Clinical Trials.gov • Trial results on Potassium-sparing diuretic • Clinical Trials on Potassium-sparing diuretic at Google
| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Potassium-sparing diuretic
| list6 = US National Guidelines Clearinghouse on Potassium-sparing diuretic • NICE Guidance on Potassium-sparing diuretic • NHS PRODIGY Guidance • FDA on Potassium-sparing diuretic • CDC on Potassium-sparing diuretic
| group7 = Textbook Information on Potassium-sparing diuretic
| list7 = Books and Textbook Information on Potassium-sparing diuretic
| group8 = Pharmacology Resources on Potassium-sparing diuretic
| list8 =
AND (Dose)}} Dosing of Potassium-sparing diuretic • AND (drug interactions)}} Drug interactions with Potassium-sparing diuretic • AND (side effects)}} Side effects of Potassium-sparing diuretic • AND (Allergy)}} Allergic reactions to Potassium-sparing diuretic • AND (overdose)}} Overdose information on Potassium-sparing diuretic • AND (carcinogenicity)}} Carcinogenicity information on Potassium-sparing diuretic • AND (pregnancy)}} Potassium-sparing diuretic in pregnancy • AND (pharmacokinetics)}} Pharmacokinetics of Potassium-sparing diuretic •
| group9 = Genetics, Pharmacogenomics, and Proteinomics of Potassium-sparing diuretic
| list9 =
AND (pharmacogenomics)}} Genetics of Potassium-sparing diuretic • AND (pharmacogenomics)}} Pharmacogenomics of Potassium-sparing diuretic • AND (proteomics)}} Proteomics of Potassium-sparing diuretic
| group10 = Newstories on Potassium-sparing diuretic
| list10 = Potassium-sparing diuretic in the news • Be alerted to news on Potassium-sparing diuretic • News trends on Potassium-sparing diuretic</small>
| group11 = Commentary on Potassium-sparing diuretic
| list11 =
Blogs on Potassium-sparing diuretic
| group12 = Patient Resources on Potassium-sparing diuretic | list12 = Patient resources on Potassium-sparing diuretic • Discussion groups on Potassium-sparing diuretic • Patient Handouts on Potassium-sparing diuretic • Directions to Hospitals Treating Potassium-sparing diuretic • Risk calculators and risk factors for Potassium-sparing diuretic
| group13 = Healthcare Provider Resources on Potassium-sparing diuretic
| list13 =
Symptoms of Potassium-sparing diuretic • Causes & Risk Factors for Potassium-sparing diuretic • Diagnostic studies for Potassium-sparing diuretic • Treatment of Potassium-sparing diuretic
| group14 = Continuing Medical Education (CME) Programs on Potassium-sparing diuretic | list14 = CME Programs on Potassium-sparing diuretic
| group15 = International Resources on Potassium-sparing diuretic | list15 = Potassium-sparing diuretic en Espanol • Potassium-sparing diuretic en Francais
| group16 = Business Resources on Potassium-sparing diuretic | list16 = Potassium-sparing diuretic in the Marketplace • Patents on Potassium-sparing diuretic
| group17 = Informatics Resources on Potassium-sparing diuretic | list17 = List of terms related to Potassium-sparing diuretic
}}
Table of Contents In Alphabetical Order | By Individual Diseases | Signs and Symptoms | Physical Examination | Lab Tests | Drugs
Editor Tools Become an Editor | Editors Help Menu | Create a Page | Edit a Page | Upload a Picture or File | Printable version | Permanent link | Maintain Pages | What Pages Link HereThere is no pharmaceutical or device industry support for this site and we need your viewer supported Donations | Editorial Board | Governance | Licensing | Disclaimers | Avoid Plagiarism | Policies
