Pargyline

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Pargyline
Systematic (IUPAC) name
N-Benzyl-N-methyl-prop-2-yn-1-amine
Identifiers
CAS number	555-57-7
ATC code	C02KC01 C02 LL01
PubChem	4688
Chemical data
Formula	C₁₁H₁₃N
Mol. mass	195.69 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Pargyline is a monoamine oxidase B (MAO-B) inhibitor. It functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Patients taking pargyline must avoid concurrent consumption of tyramine-containing foods such as bleu cheese and beer, as this can lead to a hypertensive crisis.^[1]

References

↑ Tulane University School of Medicine Department of Pharmacology: Autonomic Drug Profile handout, October 2006

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