Ketanserin

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Ketanserin
Systematic (IUPAC) name
 ?
Identifiers
CAS number 74050-98-9
ATC code C02KD01
PubChem 3822
Chemical data
Formula C22FN3O3 
Mol. mass 395.43 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

Ketanserin is a serotonin receptor antagonist. It has the highest affinity for the serotonin 5-HT2A receptor, but also binds less potently to the 5-HT2C, 5-HT2B, 5-HT1D, alpha-adrenergic, and dopamine receptors. With tritium radioactively labeled ketanserin is used as a radioligand for the serotonin 5-HT2A receptor, e.g. in receptor binding assays.

Ketanserin was discovered at Janssen Pharmaceutica in 1980.

It is classified as an antihypertensive by the World Health Organization[1] and the National Institute of Health.[2]

References

  1. http://www.whocc.no/atcddd/indexdatabase/index.php?query=C02KD01
  2. http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?mode=&term=Ketanserin



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