Acute tubular necrosis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [2]

Overview

Acute tubular necrosis is commonly caused by renal ischemia resulting from conditions such as volume depletion, hypotension, septic shock, heart failure, cirrhosis, and DIC. It is also caused by exposure to various nephrotoxic medications including aminoglycosides, amphotericin B, ACE inhibitors, NSAIDs, antiviral drugs, and also caused by exposure to radio contrast substances.

Causes

Life-threatening Causes

  • Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
  • Life-threatening causes of acute tubular necrosis may include marked volume depletion, septic shock, DIC, and hypotension.

Common Causes

Acute tubular necrosis is commonly caused by renal hypoperfusion resulting in ischemia, nephrotoxic medications and nephrotoxic substance exposure.

Causes by Organ System

Cardiovascular Heart failure
Chemical/Poisoning Ethylene glycol poisoning
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect

Aminoglycosides, amphotericin B, contrast media, cisplatin, ifosfamide, foscarnet, pentamidine, cidofovir, tenofovir, acyclovir, bisphosphonates, Cephalosporin, naproxen, tacrolimus, mannitol, NSAIDs, ACE inhibitors, cytotoxic drugs, cyclosporine, sucrose.

Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic Vomitings, diarrhea
Genetic No underlying causes
Hematologic Myoglobinuria, hemoglobinuria, multiple myeloma
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic Rhabdomyolysis
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Malignancy
Ophthalmologic No underlying causes
Overdose/Toxicity Vitamin C excessive intake
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte Acute crystal nephropathy
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma Fractures, Crush injuries
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order:

List the causes of acute tubular necrosis in alphabetical order.

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References

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