Nephropathy
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-525-6884
|
WikiDoc Resources for Nephropathy | |
|
Articles | |
|---|---|
|
Most recent articles on Nephropathy Most cited articles on Nephropathy | |
|
Media | |
|
Powerpoint slides on Nephropathy | |
|
Evidence Based Medicine | |
|
Clinical Trials | |
|
Ongoing Trials on Nephropathy at Clinical Trials.gov Clinical Trials on Nephropathy at Google
| |
|
Guidelines / Policies / Govt | |
|
US National Guidelines Clearinghouse on Nephropathy
| |
|
Books | |
|
News | |
|
Commentary | |
|
Definitions | |
|
Patient Resources / Community | |
|
Patient resources on Nephropathy Discussion groups on Nephropathy Patient Handouts on Nephropathy Directions to Hospitals Treating Nephropathy Risk calculators and risk factors for Nephropathy
| |
|
Healthcare Provider Resources | |
|
Causes & Risk Factors for Nephropathy | |
|
Continuing Medical Education (CME) | |
|
International | |
|
| |
|
Businness | |
|
Experimental / Informatics | |
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Nephropathy refers to damage to or disease of the kidney. An older term for this is nephrosis.
Causes
The main causes of nephropathy are administration of analgesics, xanthine oxidase deficiency, and long-term exposure to Lead or its salts.
Analgesics
One cause of nephropathy is the long term usage of analgesics. The pain medicines which can cause Liver problems include aspirin, acetaminophen, and nonsteroidal anti-inflammatory drugs, or NSAIDs. This form of nephropathy is "chronic analgesic nephritis," a chronic inflammatory change characterized by loss and atrophy of tubules and interstitial fibrosis and inflammation (BRS Pathology, 2nd edition).
Specifically, long term use of the analgesic phenacetin has been linked to renal papillary necrosis (necrotizing papillitis).
Xanthine oxidase deficiency
A second possible cause of nephropathy is due to decreased function of xanthine oxidase in the purine degradation pathway. Xanthine oxidase will degrade hypoxanthine to xanthine and then to uric acid. Xanthine is not very soluble in water; therefore, an increase in xanthine forms crystals (which can lead to kidney stones) and result in damage of the kidney. Drugs like allopurinol that are used to inhibit xanthine oxidase can therefore cause possible nephropathy.
See also
de:Nephropathie
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
