Acute tubular necrosis risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [2]

Overview

Common risk factors in the development of acute tubular necrosis include any condition that lead to decreased renal perfusion such as recent abdominal and cardiac surgery, marked hypovolemia, sepsis, hemorrhagic shock, severe pancreatitis, and diabetes mellitus. Nephrotoxic medications ( eg, ACE inhibitors, NSAIDs, aminoglycosides, radio contrast media) can also be a risk for developing acute tubular necrosis.

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Common Risk Factors

References

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  2. Nigwekar SU, Kandula P, Hix JK, Thakar CV (September 2009). "Off-pump coronary artery bypass surgery and acute kidney injury: a meta-analysis of randomized and observational studies". Am. J. Kidney Dis. 54 (3): 413–23. doi:10.1053/j.ajkd.2009.01.267. PMID 19406542.
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  9. Moreau R, Lebrec D (February 2003). "Acute renal failure in patients with cirrhosis: perspectives in the age of MELD". Hepatology. 37 (2): 233–43. doi:10.1053/jhep.2003.50084. PMID 12540770.
  10. James MT, Hemmelgarn BR, Wiebe N, Pannu N, Manns BJ, Klarenbach SW, Tonelli M (December 2010). "Glomerular filtration rate, proteinuria, and the incidence and consequences of acute kidney injury: a cohort study". Lancet. 376 (9758): 2096–103. doi:10.1016/S0140-6736(10)61271-8. PMID 21094997.

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