Peptic ulcer causes: Difference between revisions
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'''Common Causes'''<ref name="pmid19683340">{{cite journal| author=Malfertheiner P, Chan FK, McColl KE| title=Peptic ulcer disease. | journal=Lancet | year= 2009 | volume= 374 | issue= 9699 | pages= 1449-61 | pmid=19683340 | doi=10.1016/S0140-6736(09)60938-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19683340 }} </ref><ref name="pmid11960062">{{cite journal |vauthors=Hirschowitz BI, Lanas A |title=Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse |journal=J. Clin. Gastroenterol. |volume=34 |issue=5 |pages=523–8 |year=2002 |pmid=11960062 |doi= |url=}}</ref><ref name="pmid28150170">{{cite journal |vauthors=Dovjak P |title=[Duodenal ulcers, gastric ulcers and Helicobacter pylori] |language=German |journal=Z Gerontol Geriatr |volume=50 |issue=2 |pages=159–169 |year=2017 |pmid=28150170 |doi=10.1007/s00391-017-1190-x |url=}}</ref> | '''Common Causes'''<ref name="pmid19683340">{{cite journal| author=Malfertheiner P, Chan FK, McColl KE| title=Peptic ulcer disease. | journal=Lancet | year= 2009 | volume= 374 | issue= 9699 | pages= 1449-61 | pmid=19683340 | doi=10.1016/S0140-6736(09)60938-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19683340 }} </ref><ref name="pmid11960062">{{cite journal |vauthors=Hirschowitz BI, Lanas A |title=Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse |journal=J. Clin. Gastroenterol. |volume=34 |issue=5 |pages=523–8 |year=2002 |pmid=11960062 |doi= |url=}}</ref><ref name="pmid28150170">{{cite journal |vauthors=Dovjak P |title=[Duodenal ulcers, gastric ulcers and Helicobacter pylori] |language=German |journal=Z Gerontol Geriatr |volume=50 |issue=2 |pages=159–169 |year=2017 |pmid=28150170 |doi=10.1007/s00391-017-1190-x |url=}}</ref> | ||
*[[Helicobacter pylori]] | *[[Helicobacter pylori]] | ||
*[[NSAID]]s | *[[NSAID]]s | ||
Less common causes | '''Less common causes''' | ||
*[[Hormonal]] or mediator-induced including secondary acid hypersecretory states | *[[Hormonal]] or mediator-induced including secondary acid hypersecretory states | ||
**[[Gastrinomas]] | **[[Gastrinomas]] | ||
| Line 16: | Line 16: | ||
** [[Carcinoid syndrome]] | ** [[Carcinoid syndrome]] | ||
** [[Myeloproliferative disease|Myeloproliferative disorder]] | ** [[Myeloproliferative disease|Myeloproliferative disorder]] | ||
*Antral | *Antral G-cell hyperfunction | ||
*Post-surgical | *Post-surgical antral exclusion and post [[gastric]] bypass [[surgery]] | ||
* | *Cancers and [[lymphoma|lymphomas]] | ||
*Cameron [[ulcer]] ([[gastric]] [[ulcer]] where a [[hiatus hernia]] passes through the [[diaphragmatic hiatus]]) | *Cameron [[ulcer]] ([[gastric]] [[ulcer]] where a [[hiatus hernia]] passes through the [[diaphragmatic hiatus]]) | ||
*True idiopathic [[ulcer]] | *True idiopathic [[ulcer]] | ||
| Line 27: | Line 27: | ||
* [[Radiation]] damage | * [[Radiation]] damage | ||
* [[Viral infections]] (eg [[cytomegalovirus]] or [[Herpes simplex|herpes simplex infection]], in particular in [[immunocompromised]] patients) | * [[Viral infections]] (eg [[cytomegalovirus]] or [[Herpes simplex|herpes simplex infection]], in particular in [[immunocompromised]] patients) | ||
* | *Colonization of [[stomach]] with H heilmanii | ||
* Severe [[systemic disease]] | * Severe [[systemic disease]] | ||
'''Genetic causes''' | '''Genetic causes'''<ref name="pmid17312377">{{cite journal| author=Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V et al.| title=Gastrinoma (duodenal and pancreatic). | journal=Neuroendocrinology | year= 2006 | volume= 84 | issue= 3 | pages= 173-82 | pmid=17312377 | doi=10.1159/000098009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17312377 }} </ref> | ||
*Peptic ulcer disease | *Peptic ulcer disease caused by gastrinomas [[Zollinger-Ellison syndrome|(Zollinger-Ellison syndrome]]) caused by a [[mutation]] in MEN [[gene]] present on [[chromosome]] 11q13 | ||
===Causes by Organ System=== | ===Causes by Organ System=== | ||
Revision as of 15:34, 7 December 2017
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Peptic ulcer Microchapters |
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Diagnosis |
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Treatment |
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Surgery |
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Case Studies |
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2017 ACG Guidelines for Peptic Ulcer Disease |
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Guidelines for the Indications to Test for, and to Treat, H. pylori Infection |
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Guidlines for factors that predict the successful eradication when treating H. pylori infection |
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Guidelines to document H. pylori antimicrobial resistance in the North America |
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Guidelines for evaluation and testing of H. pylori antibiotic resistance |
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Guidelines for when to test for treatment success after H. pylori eradication therapy |
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Guidelines for penicillin allergy in patients with H. pylori infection |
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Peptic ulcer causes On the Web |
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American Roentgen Ray Society Images of Peptic ulcer causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ;Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
Common causes of peptic ulcer disease include Helicobacter pylori infection and NSAID use. Less common causes of peptic ulcer disease include Crohn's disease, Zollinger-Ellison syndrome, Cushing and Curling ulcers, Carcinoid tumors, and carcinoid syndrome.
Causes
Less common causes
- Hormonal or mediator-induced including secondary acid hypersecretory states
- Antral G-cell hyperfunction
- Post-surgical antral exclusion and post gastric bypass surgery
- Cancers and lymphomas
- Cameron ulcer (gastric ulcer where a hiatus hernia passes through the diaphragmatic hiatus)
- True idiopathic ulcer
Rare causes of peptic ulcer disease
- Crohn’s disease of the stomach or duodenum
- Eosinophilic gastroduodenitis
- Systemic mastocytosis
- Radiation damage
- Viral infections (eg cytomegalovirus or herpes simplex infection, in particular in immunocompromised patients)
- Colonization of stomach with H heilmanii
- Severe systemic disease
Genetic causes[4]
- Peptic ulcer disease caused by gastrinomas (Zollinger-Ellison syndrome) caused by a mutation in MEN gene present on chromosome 11q13
Causes by Organ System
Causes in Alphabetical Order
References
- ↑ Malfertheiner P, Chan FK, McColl KE (2009). "Peptic ulcer disease". Lancet. 374 (9699): 1449–61. doi:10.1016/S0140-6736(09)60938-7. PMID 19683340.
- ↑ Hirschowitz BI, Lanas A (2002). "Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse". J. Clin. Gastroenterol. 34 (5): 523–8. PMID 11960062.
- ↑ Dovjak P (2017). "[Duodenal ulcers, gastric ulcers and Helicobacter pylori]". Z Gerontol Geriatr (in German). 50 (2): 159–169. doi:10.1007/s00391-017-1190-x. PMID 28150170.
- ↑ Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V; et al. (2006). "Gastrinoma (duodenal and pancreatic)". Neuroendocrinology. 84 (3): 173–82. doi:10.1159/000098009. PMID 17312377.
- ↑ Kutlubay Z, Zara T, Engin B, Serdaroğlu S, Tüzün Y, Yilmaz E; et al. (2014). "Helicobacter pylori infection and skin disorders". Hong Kong Med J. 20 (4): 317–24. doi:10.12809/hkmj134174. PMID 25045884.
- ↑