Peptic ulcer history and symptoms

Jump to navigation Jump to search

Peptic ulcer Microchapters


Patient Information


Historical Perspective




Differentiating Peptic Ulcer from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis


Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Upper GI Endoscopy

X Ray




Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Endoscopic management
Surgical management

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

2017 ACG Guidelines for Peptic Ulcer Disease

Guidelines for the Indications to Test for, and to Treat, H. pylori Infection

Guidelines for First line Treatment Strategies of Peptic Ulcer Disease for Providers in North America

Guidlines for factors that predict the successful eradication when treating H. pylori infection

Guidelines to document H. pylori antimicrobial resistance in the North America

Guidelines for evaluation and testing of H. pylori antibiotic resistance

Guidelines for when to test for treatment success after H. pylori eradication therapy

Guidelines for penicillin allergy in patients with H. pylori infection

Guidelines for the salvage therapy

Peptic ulcer history and symptoms On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Peptic ulcer history and symptoms

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical

US National Guidelines Clearinghouse

NICE Guidance

FDA on Peptic ulcer history and symptoms

CDC on Peptic ulcer history and symptoms

Peptic ulcer history and symptoms in the news

Blogs on Peptic ulcer history and symptoms

to Hospitals Treating Peptic ulcer

Risk calculators and risk factors for Peptic ulcer history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:  :Manpreet Kaur, MD [2]


The hallmark of peptic ulcer disease is an episodic epigastric pain which cause awakening at night. A positive history of epigastric pain, use of drugs like NSAIDs including aspirin which inhibit cyclooxygenase, use of antiplatelets,steroids and family history of peptic ulcer disease is suggestive of peptic ulcer disease. The most common symptoms of peptic ulcer disease include episodic epigastric pain, heartburn, loss of appettite, gastroesophageal reflux, waterbrash, hematemesis and melena. Less common symptoms of peptic ulcer disease include intolerance to fatty food.


Obtaining the history is the most important aspect of making a diagnosis of peptic ulcer disease. It provides insight into the cause, precipitating factors and associated comorbid conditions.

Past Medical History

Medication History

Social History

Family History


Difference in symptoms of gastric and duodenal ulcer
Gastric ulcer Duodenal ulcer
Epigastric pain Occurs 1-2 hours after eating Occurs 2-5 hours after eating
Increases with eating Decreases with eating
Pain at night is less common Pain at night is more common
Heartburn, chest discomfort

and early satiety

Occurs commonly Less commonly occurs
Bleeding presentation

Common Symptoms

Common symptoms of peptic ulcer disease include:

Less Common Symptoms

Less common symptoms of peptic ulcer disease include:


  1. Laine, Loren; Solomon, Caren G. (2016). "Upper Gastrointestinal Bleeding Due to a Peptic Ulcer". New England Journal of Medicine. 374 (24): 2367–2376. doi:10.1056/NEJMcp1514257. ISSN 0028-4793.
  2. 2.0 2.1 Ramakrishnan K, Salinas RC (2007). "Peptic ulcer disease". Am Fam Physician. 76 (7): 1005–12. PMID 17956071.
  3. Drini M (2017). "Peptic ulcer disease and non-steroidal anti-inflammatory drugs". Aust Prescr. 40 (3): 91–93. doi:10.18773/austprescr.2017.037. PMC 5478398. PMID 28798512.
  4. 4.0 4.1 Goulston K, Cooke AR (1968). "Alcohol, aspirin, and gastrointestinal bleeding". Br Med J. 4 (5632): 664–5. PMC 1912769. PMID 5303551.
  5. Bruce MG, Maaroos HI (2008). "Epidemiology of Helicobacter pylori infection". Helicobacter. 13 Suppl 1: 1–6. doi:10.1111/j.1523-5378.2008.00631.x. PMID 18783514.
  6. MacMath TL (1990). "Alcohol and gastrointestinal bleeding". Emerg. Med. Clin. North Am. 8 (4): 859–72. PMID 2226291.
  7. Jafar W, Jafar A, Sharma A (2016). "Upper gastrointestinal haemorrhage: an update". Frontline Gastroenterol. 7 (1): 32–40. doi:10.1136/flgastro-2014-100492. PMC 5369541. PMID 28839832. Vancouver style error: initials (help)
  8. Palmer K (2007). "Acute upper gastrointestinal haemorrhage". Br. Med. Bull. 83: 307–24. doi:10.1093/bmb/ldm023. PMID 17942452.

Template:WikiDoc Sources