Pemirolast

Pemirolast

Clinical data
Trade names	Alamast
AHFS/Drugs.com	Monograph
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Oral, ophthalmic
ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
CAS Number	69372-19-6 Y
PubChem CID	57697
ChemSpider	51990 N
UNII	2C09NV773M
KEGG	D07476 Y
ChEMBL	ChEMBL1201198 N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C10H8N6O
Molar mass	228.21 g/mol
3D model (JSmol)	Interactive image
SMILES CC1=CC=CN2C1=NC=C(C2=O)C3=NNN=N3
NY (what is this?)  (verify)

Overview

Pemirolast (INN) is an anti-allergic drug. It is marketed under the tradenames Alegysal and Alamast.

It has also been studied for the treatment of asthma.

References

• Tinkelman DG, Berkowitz RB (1991). "A pilot study of pemirolast in patients with seasonal allergic rhinitis". Ann Allergy. 66 (2): 162–5. PMID 1994787.
• Kawashima T, Iwamoto I, Nakagawa N, Tomioka H, Yoshida S (1994). "Inhibitory effect of pemirolast, a novel antiallergic drug, on leukotriene C4 and granule protein release from human eosinophils". Int. Arch. Allergy Immunol. 103 (4): 405–9. doi:10.1159/000236662. PMID 8130655.CS1 maint: Multiple names: authors list (link)
• Abelson MB, Berdy GJ, Mundorf T, Amdahl LD, Graves AL (2002). "Pemirolast potassium 0.1% ophthalmic solution is an effective treatment for allergic conjunctivitis: a pooled analysis of two prospective, randomized, double-masked, placebo-controlled, phase III studies". J Ocul Pharmacol Ther. 18 (5): 475–88. doi:10.1089/10807680260362759. PMID 12419098. CS1 maint: Multiple names: authors list (link)
• Kemp JP, Bernstein IL, Bierman CW; et al. (1992). "Pemirolast, a new oral nonbronchodilator drug for chronic asthma". Ann Allergy. 68 (6): 488–91. PMID 1610024. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• Mitsubishi Tanabe Pharma Corporation (2007). "ALEGYSAL (English)" (PDF). Retrieved 2008-09-02.
• VISTAKON Pharmaceuticals, LLC (2005). "ALAMAST (pemirolast potassium opthalmic solution) 0.1%". Retrieved 2008-09-02.

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