Leg pain

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Complete Differential Diagnosis of the causes of Leg pain

(By organ system)

Cardiovascular	Aortoiliac occlusive disease,Cholesterol Emboli Syndrome,Deep Vein Thrombosis,Peripheral Arterial Disease,Thrombophlebitis,Varicose veins
Chemical / poisoning	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Abatacept Injection,Acebutolol,Acitretin,Aldesleukin,Alendronate,Allopurinol,Amikacin Sulfate Injection,Anagrelide,Anastrozole,Aripiprazole,Atazanavir,Atenolol,Atorvastatin,Bevacizumab Injection,Bortezomib,Buspirone,Capecitabine,Celecoxib,Celiac disease,Clofarabine Injection,Clonazepam,Clopidogrel,Cortisol,Darbepoetin Alfa,Docetaxel,Epoetin Alfa Injection,Ethacrynic Acid,Etidronate,Ezetimibe,Fenofibrate,Filgrastim,Fluvastatin,Gabapentin,Galantamine,Glatiramer Injection,Ibandronate,Iloprost,Imatinib,Infliximab Injection,Interferon Alfa-2a and Alfa-2b Injection,Interferon Alfacon-1 Injection,Interferon beta-1a Intramuscular Injection,Interferon Beta-1b Injection,Interferon Gamma-1b Injection,Lamivudine,Latanoprost,Leflunomide,Letrozole,Leuprolide,Lovastatin,Methimazole,Methylergonovine,Methylprednisolone,Mifepristone,Natalizumab injection ,Ofloxacin ,Paclitaxel,Peginterferon alfa-2a,Prednisone,Pyrazinamide,Quinupristin dalfopristin,Ribavirin,Rofecoxib,Rosiglitazone,Rosuvastatin,Sunitinib ,Tadalafil ,Tamsulosin ,Telbivudine ,Temozolomide ,Terbutaline,Teriparatide,Tiotropium,Torsemide,Valganciclovir,Valsartan,Vancomycin,Vinblastine,Vincristine,Zalcitabine,Ziprasidone,Zolmitriptan,Zolpidem,
Ear Nose Throat	No underlying causes
Endocrine	Hyperparathyroidism,Primary hyperparathyroidism
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	Fairbanks disease,Familial Mediterranean fever,Mitochondrial trifunctional protein deficiency,Osteogenesis imperfecta
Hematologic	Erdheim-Chester disease,Leukemia,Lymphangiomatosis,Multiple myeloma,Phlebitis,Phlegmasia cerulea dolens,Thrombocytosis
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal / Ortho	Athlete's foot,Baker's cyst,Bone tumor,Buerger's disease,Chondroblastoma,Chondromalacia patellae,Chondrosarcoma,Gout,Hereditary multiple exostoses,Ledderhose's disease,Legg-Calve-Perthes syndrome,Morton's toe,Myofascial Pain Syndrome,Myositis ossificans,Osteochondrosis,Paget's disease of bone,Pes anserinus (leg),Pigmented villonodular synovitis,Prepatellar bursitis,Recessive multiple epiphyseal dysplasia,Retropatellar Pain Syndrome,Sciatica,Synovial osteochondromatosis,Tenosynovitis
Neurologic	Amyotrophic Lateral Sclerosis,Anterior spinal artery syndrome,Erythromelagia,Meralgia paraesthetica,Peripheral Neuropathy
Nutritional / Metabolic	Acute Intermittent Porphyria,Farber disease,Glycogen storage disease type V,Hypercalcemia,Mucopolysaccharidosis,Osteomalacia
Obstetric/Gynecologic	No underlying causes
Oncologic	Acute lymphoblastic leukemia,Acute myeloid leukemia,Acute promyelocytic leukemia,Ewing's sarcoma,Giant cell tumor of bone,Osteochondroma,Osteoma,Osteosarcoma
Opthalmologic	No underlying causes
Overdose / Toxicity	No underlying causes
Psychiatric	Pain disorder
Pulmonary	No underlying causes
Renal / Electrolyte	Hypercalcemia
Rheum / Immune / Allergy	Rheumatology : Ankylosing Spondylitis,Behect's disease,Caplan's Syndrome,Fibromyalgia,Osteoarthritis,Osteoporosis,Polymyalgia Rheumatica,Rheumatoid arthritis,Still's disease, Gout Immunology : Systemic lupus erythematosus,Ulcerative colitis,Vasculitis,Graft-versus-host disease,Familial Mediterranean fever
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	Phantom pain

In alphabetical order:

• Arterial thromboembolism
• Arthritis
• Autoimmune vascular disorders such as vasculitis
• Baker's cyst
• Cholesterol embolism
• Chronic venous insufficiency
• Connective tissue disease
• Coxsackie B
• Deep Vein Thrombosis (DVT)
• Drugs, toxins
• Hypocalcemia
• Hypokalemia
• Hyponatremia
• Leptospirosis
• Ligament damage
• Lumbar canal stenosis or spinal stenosis
• Muscle or tendon strain
• Night cramps
• Obliterating endarteritis
• Peripheral neuropathy
• Peripheral vascular disease
• Plexopathy
• Primary varicosis
• Radiculopathy
• Restless Leg Syndrome
• Venous thromboembolism (VTE)

References

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