Lactic acidosis causes: Difference between revisions

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{{CMG}}
{{CMG}}
==Overview==
==Overview==
*[[AIDS]]
 
*[[Cancer]]
==Causes==
* Drugs, toxins
===Life Threatening Causes===
* End-stage [[renal failure]]
* Fetal compromise during childbirth
* [[Glycogen storage disease]]
* [[Heart failure]]
* Heavy exercise
* [[Hypothermia]]
* [[Hypoventilation]] with [[hypercapnia]]
* [[Hypovolemia]]
* Infusions
* [[Leukemia]]
* [[Hepatic failure|Liver failure]]
* [[Myocardial Infarction]]
* Postoperative state
* [[Seizures]]
* [[Sepsis]]
* Severe [[anemia]]
* Severe [[thiamine deficiency]]
* [[Tumors]]
* Uncontrolled [[diabetes mellitus]]


===Common Causes===
===Common Causes===
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===Causes by Organ System===
===Causes by Organ System===
{|style="width:82%; height:100px" border="1"
{|style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" |ST Elevation [[Myocardial Infarction]] Complications , [[Shock]] , [[Heart diseases]] , [[Cardiomyopathy ]] , [[Cardiac arrest ]] , [[Beriberi Heart Disease]] , Acute [[pulmonary edema ]]
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" |ST Elevation [[Myocardial Infarction]] Complications , [[Shock]] , [[Heart diseases]] , [[Cardiomyopathy ]] , [[Cardiac arrest ]] , [[Beriberi Heart Disease]] , Acute [[pulmonary edema ]]
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===Causes in Alphabetical Order===
===Causes in Alphabetical Order===
{{Multicol}}
{{col-begin|width=80%}}
*[[Abacavir]]
{{col-break|width=33%}}
*[[Abacavir]]
*[[Abacavir]]
*[[Acquired immune deficiency syndrome ]]
*[[Acquired immune deficiency syndrome]]
*[[Acute liver failure]]
*[[Acute liver failure]]
*Acute [[pulmonary edema ]]
*[[Adefovir]]
*[[Adefovir ]]
*[[Alcoholism]]
*[[Alcoholism ]]
*[[Anemia]]
*[[Ariboflavinosis]]
*[[Ariboflavinosis]]
*[[Asthma]]
*[[Atenolol]]
*[[Atenolol]]
*[[Bacterial overgrowth]] of small intestine
*[[Bacterial overgrowth|Bacterial overgrowth of small intestine]]
*[[Beriberi Heart Disease]]
*[[Beriberi Heart Disease]]
*[[Biguanide]]
*[[Biguanide]]
*[[Buformin]]
*[[Buformin]]
*[[Burkitt's lymphoma]]
*[[Burkitt's lymphoma]]
*[[Carbon monoxide poisoning ]]
*[[Cancer]]
*[[Carbon monoxide poisoning]]
*[[Carbon monoxide poisoning]]
*[[Cardiac arrest ]]
*[[Cardiac arrest]]
*[[Cardiac Catheterization]]
*[[Cardiomyopathy ]]
*[[Cardiomyopathy ]]
*[[Chronic fatigue syndrome]]
*[[Chronic fatigue syndrome]]
*[[Coenzyme Q]] cytochrome c reductase deficiency
*[[Coenzyme Q cytochrome c reductase deficiency]]
*[[Coenzyme Q10]] deficiency
*[[Coenzyme Q10|Coenzyme Q10 deficiency]]
*Complications During and Following [[Cardiac Catheterization]]
*[[Contrast medium]]
*[[Contrast medium]]
*Copperhead snake [[poisoning ]]
*[[Cyanide poisoning]]
*Crotalidae snake [[poisoning ]]
*Cuffed blood sample
*[[Cyanide ]]intoxication
*[[Decreased activity  [[pyruvate carboxylase ]]
*[[Decreased activity of [[pyruvate dehydrogenase  ]]
*Decreased [[oxygen]] delivery 
*[[Diabetes mellitus]]
*[[Diabetic nephropathy]]
*[[Diabetic nephropathy]]
*[[Didanosine]]
*[[Didanosine]]
*Dihydrolipoamide dehydrogenase deficiency
*Dye-contrast medical tests - can cause LA by inhibiting the kidneys.
*[[Emtricitabine]]
*[[Emtricitabine]]
*[[Entecavir]]
*[[Entecavir]]
*[[Ethanol]]
*[[Ethanol]]
*[[Ethylmalonic encephalopathy]]
*[[Ethylmalonic encephalopathy]]
*[[Exercise]]
*[[Fetal distress]]
*[[Fetal distress]]
*Finnish lethal neonatal [[metabolic syndrome ]]
{{col-break|width=33%}}
*Fire
*[[Fructose intolerance]]
*[[Fructose intolerance]]
*[[Fructose-1-phosphate aldolase deficiency]]
*[[Fructose-1-phosphate aldolase deficiency]]
*[[Fructose-1, 6-diphosphatase deficiency]]
*[[Fructose-1,6-diphosphatase deficiency]]
{{ColBreak}}
*[[Glycogen storage disease]]
*[[Fructose-1,6-bisphosphatase deficiency, hereditary ]]
*[[Glyburide]] and [[Metformin ]]
*[[Glycogen storage disease]] type 1C
*[[Glycogen storage disease]] type 1D
*[[Glycogen Storage Disease]] Type I
*[[Glycogenosis]] type 1a
*[[Glycogenosis]] type 1b
*[[GRACILE syndrome]]
*[[GRACILE syndrome]]
*[[Grand mal seizure ]]
*[[Grand mal seizure ]]
*[[Haemorrhage]]
*[[Hemorrhage]]
*[[Heart diseases]]
*[[Heart failure]]
*[[Hemofiltration]]
*[[Hemofiltration]]
*[[Hepatic failure]]
*[[Hepatic failure|Liver failure]]
*[[Holocarboxylase synthase deficiency]]
*[[Holocarboxylase synthase deficiency]]
*Hydroxyacyl-coa dehydrogenase, type 2, deficiency
*[[Hypercapnia]]
*[[Hypoglycemia]]
*[[Hypoglycemia]]
*[[Hypoperfusion]]
*[[Hypoperfusion]]
*Hypothermic shivering
*[[Hypothermia]]
*[[Hypovolemia]]
*[[Hypoxia]]
*[[Hypoxia]]
*[[Idiopathic]]
*[[Idiopathic]]
*Impaired [[pyruvate]] utilization
*[[Intestinal ischemia]]
*[[Intestinal ischaemia]]
*[[Intravenous pyelogram]]
*[[Intravenous pyelogram]]
*[[Isopropyl alcohol]]
*[[Isopropyl alcohol]]
*[[Lamivudine ]]
*[[Lamivudine]]
*[[Latent autoimmune diabetes]]
*[[Latent autoimmune diabetes]]
*[[Leukemia]]
*[[Linezolid]]
*[[Linezolid]]
*[[Liver disease]]
*[[Liver disease]]
*Lung disease - reduced [[oxygen]] intake
*Malignancy
*[[Malignant hyperpyrexia]]
*[[Malignant hyperpyrexia]]
*[[Malonyl-CoA decarboxylase deficiency]]
*[[Malonyl-CoA decarboxylase deficiency]]
*[[Malonyl-CoA decarboxylase deficiency]]
*Marked [[acidemia ]]
*Medium and long chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency
*[[MELAS]]
*[[MELAS]]
*[[MERRF]]
*[[MERRF]]
*[[Mesenteric ischemia]]
*[[Mesenteric ischemia]]
*[[Metabolic syndrome]]
{{col-break|width=33%}}
*[[Metformin]]
*[[Metformin]]
*[[Mitochondrial]] aspartyl-tRNA synthetase deficiency
*[[Mitochondrial]] DNA depletion syndrome
*[[Mitochondrial]] encephalomyopathy -- aminoacidopathy
*[[Mitochondrial]] genome inherited conditions
*[[Mitochondrial myopathy]]
*[[Mitochondrial myopathy]]
{{ColBreak}}
*[[Mitochondrial ]]neurogastrointestinal encephalopathy syndrome
*[[Mitochondrial toxicity]]
*[[Mitochondrial toxicity]]
*Multiple organ dysfunction syndrome
*[[Multiple organ dysfunction syndrome]]
*[[Myopathy]] with deficiency of succinate dehydrogenase and aconitase]]
*[[Myocardial Infarction]]
*[[Non Hodgkin's lymphoma]]
*[[Non Hodgkin's lymphoma]]
*[[Oligohydramnios]]
*[[Paracetamol]]
*[[Paracetamol]]
*[[Phenformin]]
*[[Phenformin]]
*[[Pheochromocytoma ]]
*[[Pheochromocytoma]]
*Pyridoxine-5'-phosphate oxidase deficiency
*[[Pulmonary edema]]
*[[Pyruvate carboxylase]] deficiency
*[[Pyruvate carboxylase deficiency]]
*Pyruvate decarboxylase deficiency
*[[Pyruvate dehydrogenase deficiency]]
*[[Pyruvate dehydrogenase]] deficiency
*[[Renal failure]]
*[[Pyruvate dehydrogenase phosphatase deficiency ]]
*Reduced oxygen utilization
*[[Renal failure, chronic]]
*[[Respiratory failure]]
*[[Respiratory failure]]
*[[Reye's syndrome]]
*[[Reye's syndrome]]
*[[Salicylate intoxication ]]
*[[Salicylate intoxication]]
*SCHAD deficiency
*[[Seizures]]
*[[Sepsis]]
*[[Sepsis]]
*Severe [[asthma ]]
*Severe [[exercise ]]
*Severe [[hypoxemia]] (PO2 <25 to 30 mmHg)
*[[Shock]]
*[[Shock]]
*[[Short bowel syndrome]]
*[[Short bowel syndrome]]
*[[Smoke inhalation ]]
*[[Smoke inhalation]]
*[[ST Elevation Myocardial Infarction Complications]]
*[[ST Elevation Myocardial Infarction Complications]]
*[[Stavudine]]
*[[Stavudine]]
*[[Strychnine]]
*[[Strychnine]]
*Subacute necrotising [[encephalomyelopathy]]
*[[Telbivudine]]
*Succinic [[acidemia ]]
*[[Tenofovir]]
*Succinyl-CoA synthetase deficiency
*[[thiamine deficiency]]
*[[Telbivudine ]]
*[[Tumors]]
*[[Tenofovir ]]
*[[Von Gierke Disease]]
*Type 1 [[glycogen storage disease ]]
*Type I [[Glycogen Storage Disease ]]
*[[Von Gierke Disease ]]
*[[Zalcitabine]]
*[[Zalcitabine]]
*17- beta-hydroxysteroid dehydrogenase X deficiency
{{col-end}}
*3-Hydroxyacyl-CoA Dehydrogenase II Deficiency
*3-Hydroxyisobutyric aciduria
*3-methylglutaconic aciduria, type 4
{{EndMultiCol}}


==References==
==References==

Revision as of 18:56, 22 July 2013

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Causes

Life Threatening Causes

Common Causes

Causes by Organ System

Cardiovascular ST Elevation Myocardial Infarction Complications , Shock , Heart diseases , Cardiomyopathy , Cardiac arrest , Beriberi Heart Disease , Acute pulmonary edema
Chemical/Poisoning Isopropyl alcohol , Ethanol , Cyanide intoxication , Crotalidae snake poisoning , Copperhead snake poisoning , Contrast medium , Complications During and Following Cardiac Catheterization, Carbon monoxide poisoning , Alcoholism
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Zalcitabine , Tenofovir , Telbivudine , Succinyl-CoA synthetase deficiency , Stavudine , Phenformin , Paracetamol , Metformin , Linezolid , Lamivudine , Glyburide and Metformin , Entecavir , Emtricitabine , Didanosine , Buformin , Biguanide , Atenolol , Ariboflavinosis , Adefovir , Abacavir , Abacavir
Ear Nose Throat No underlying causes
Endocrine Pheochromocytoma , Latent autoimmune diabetes , Hypoglycemia , Diabetic nephropathy , Diabetes mellitus
Environmental Smoke inhalation
Gastroenterologic Short bowel syndrome , Mesenteric ischemia , Liver disease , Intestinal ischaemia , Hepatic failure , Bacterial overgrowth of small intestine , Acute liver failure
Genetic Type I Glycogen Storage Disease , Type 1 glycogen storage disease , SCHAD deficiency , Pyruvate dehydrogenase phosphatase deficiency , Pyruvate dehydrogenase deficiency, Pyruvate decarboxylase deficiency, Pyruvate carboxylase deficiency, Pyridoxine-5'-phosphate oxidase deficiency, Myopathy with deficiency of succinate dehydrogenase and aconitase, Mitochondrial genome inherited conditions, Mitochondrial encephalomyopathy -- aminoacidopathy , Mitochondrial DNA depletion syndrome , Mitochondrial aspartyl-tRNA synthetase deficiency , Medium and long chan 3-hydroxyacyl-coenzyme A dehydrogenase deficiency , Malonyl-CoA decarboxylase deficiency, Malonyl-CoA decarboxylase deficiency , Malignant hyperpyrexia, Hydroxyacyl-coa dehydrogenase type 2 deficiency , Holocarboxylase synthase deficiency , GRACILE syndrome ,Glycogenosis type 1b, Glycogenosis type 1a, Glycogen Storage Disease Type I , Glycogen storage disease type 1D , Glycogen storage disease type 1C , Fructose-1,6-bisphosphatase deficiency, , Fructose-1,6-diphosphatase deficiency, Fructose-1-phosphate aldolase deficiency, Fructose intolerance, Dihydrolipoamide dehydrogenase deficiency, Decreased activity of pyruvate dehydrogenase , Decreased activity pyruvate carboxylase , 3-methylglutaconic aciduria, type 4 , 3-Hydroxyisobutyric aciduria, 3-Hydroxyacyl-CoA Dehydrogenase II Deficiency , 17- beta-hydroxysteroid dehydrogenase X deficiency
Hematologic Burkitt's lymphoma
Iatrogenic No underlying causes
Infectious Disease Sepsis , Acquired immune deficiency syndrome
Musculoskeletal/Orthopedic No underlying causes
Neurologic Subacute necrotising encephalomyelopathy , Grand mal seizure , Ethylmalonic encephalopathy
Nutritional/Metabolic Von Gierke Disease , Mitochondrial toxicity , Mitochondrial neurogastrointestinal encephalopathy syndrome , Mitochondrial myopathy , Impaired pyruvate utilization , Coenzyme Q10 deficiency
Obstetric/Gynecologic Fetal distress
Oncologic Non Hodgkin's lymphoma , Malignancy
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Severehypoxemia (PO2 <25 to 30 mmHg) , Severe asthma , Respiratory failure , Lung disease - reduced oxygen intake , Hypoxia
Renal/Electrolyte Renal failure , Hemofiltration
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Succinic acidemia , Strychnine , Severe exercise , Reye's syndrome , Reduced oxygen utilization , Multiple organ dysfunction , Marked acidemia , Intravenous pyelogram , Idiopathic , Hypothermic shivering , Hypoperfusion , Haemorrhage , Finnish lethal neonatal metabolic syndrome , Decreased oxygen delivery , Cuffed blood sample, Chronic fatigue syndrome , MERRF , MELAS

Causes in Alphabetical Order

References


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