Griffithsin: Difference between revisions
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==Overview== | ==Overview== | ||
'''Griffithsin''', is a [[protein]] isolated from the [[red algae]] Griffithsia. It has a 121-[[amino acid sequence]].<ref>{{cite journal |author=Mori T, O'Keefe BR, Sowder RC, ''et al'' |title=Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp |journal=J. Biol. Chem. |volume=280 |issue=10 |pages=9345–53 |year=2005 |pmid=15613479 |doi=10.1074/jbc.M411122200 |url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=15613479}}</ref> It has been shown [[in vitro]] to be a highly potent [[HIV]] [[entry inhibitor]]. It is currently being investigated as a potential [[microbicide]] for use in the prevention of the transmission of [[HIV]].<ref>{{cite journal |author=Emau P, Tian B, O'keefe BR, ''et al'' |title=Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide |journal=J. Med. Primatol. |volume=36 |issue=4-5 |pages=244–53 |year=2007 |pmid=17669213 |doi=10.1111/j.1600-0684.2007.00242.x |url=http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0047-2565&date=2007&volume=36&issue=4-5&spage=244}}</ref> | '''Griffithsin''', is a [[protein]] isolated from the [[red algae]] Griffithsia. It has a 121-[[amino acid sequence]].<ref>{{cite journal |author=Mori T, O'Keefe BR, Sowder RC, ''et al'' |title=Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp |journal=J. Biol. Chem. |volume=280 |issue=10 |pages=9345–53 |year=2005 |pmid=15613479 |doi=10.1074/jbc.M411122200 |url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=15613479}}</ref> It has been shown [[in vitro]] to be a highly potent [[HIV]] [[entry inhibitor]]. It is currently being investigated as a potential [[microbicide]] for use in the prevention of the transmission of [[HIV]].<ref>{{cite journal |author=Emau P, Tian B, O'keefe BR, ''et al'' |title=Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide |journal=J. Med. Primatol. |volume=36 |issue=4-5 |pages=244–53 |year=2007 |pmid=17669213 |doi=10.1111/j.1600-0684.2007.00242.x |url=http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0047-2565&date=2007&volume=36&issue=4-5&spage=244}}</ref> | ||
Revision as of 15:45, 11 June 2009
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Overview
Griffithsin, is a protein isolated from the red algae Griffithsia. It has a 121-amino acid sequence.[1] It has been shown in vitro to be a highly potent HIV entry inhibitor. It is currently being investigated as a potential microbicide for use in the prevention of the transmission of HIV.[2]
- ↑ Mori T, O'Keefe BR, Sowder RC; et al. (2005). "Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp". J. Biol. Chem. 280 (10): 9345–53. doi:10.1074/jbc.M411122200. PMID 15613479.
- ↑ Emau P, Tian B, O'keefe BR; et al. (2007). "Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide". J. Med. Primatol. 36 (4–5): 244–53. doi:10.1111/j.1600-0684.2007.00242.x. PMID 17669213.