Griffithsin

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Overview

Griffithsin, is a protein isolated from the red algae Griffithsia. It has a 121-amino acid sequence.[1] It has been shown in vitro to be a highly potent HIV entry inhibitor. It is currently being investigated as a potential microbicide for use in the prevention of the transmission of HIV.[2]

  1. Mori T, O'Keefe BR, Sowder RC; et al. (2005). "Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp". J. Biol. Chem. 280 (10): 9345–53. doi:10.1074/jbc.M411122200. PMID 15613479.
  2. Emau P, Tian B, O'keefe BR; et al. (2007). "Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide". J. Med. Primatol. 36 (4–5): 244–53. doi:10.1111/j.1600-0684.2007.00242.x. PMID 17669213.




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