COVID-19-associated arrhythmia and conduction system disease

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For COVID-19 frequently asked inpatient questions, click here
For COVID-19 frequently asked outpatient questions, click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Tayyaba Ali, M.D.[2]

Synonyms and keywords:COVID-19-associated dysrhythmia

Overview

An arrhythmia is a problem with the rate or rhythm of the heartbeat. During an arrhythmia, the heart can beat too fast, too slowly, or with an irregular rhythm. When a heart beats too fast, the condition is called tachycardia. When a heart beats too slowly, the condition is called bradycardia. Cardiac arrhythmia is increasingly recognized as one of the earliest clinical manifestations of COVID-19. There is also anecdotal evidence of sudden cardiac death among COVID-19 patients. According to a study, 51 of 85 fatal cases of COVID-19 from Wuhan developed an arrhythmia, and 2 patients died of malignant arrhythmia. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes S-spike to bind to angiotensin-converting enzyme 2 (ACE2) receptors to enter the endothelial cells of the heart. The interaction between SARS-CoV-2 and ACE2 can bring about changes in ACE2 pathways prompting intense injury to the lung, heart, and endothelial cells. Hypoxia and electrolyte abnormalities that are common in the acute phase of severe COVID-19 can potentiate cardiac arrhythmias. COVID-19-associated arrhythmia findings include sinus tachycardia, atrial fibrillation, tachy-brady syndrome, sinus rhythm with a first-degree atrioventricular block (AVB) with SITIIIQIII and Sinus tachycardia with incomplete right bundle branch block. All patients with torsades de pointes (TdP) should be determined if they are hemodynamically stable or unstable through immediate evaluation of the symptoms, vital signs, and level of consciousness. Initial treatment with antiarrhythmic medications is not indicated for hemodynamically unstable or pulseless patients except intravenous (IV) magnesium. The clinical situation of a patient determines the rate of magnesium infusion. Infusion occurs over one to two minutes in patients with pulseless cardiac arrest. The infusion should occur over 15 minutes in patients without cardiac arrest as a rapid IV bolus of magnesium can result in hypotension and asystole. Some patients are given a continuous bolus of IV magnesium at a rate of 3 to 20 mg/min until the QT interval is below 0.50 seconds. The treatment for other arrhythmias in COVID-19 patients is the same as in patients with arrhythmias without COVID-19 infection.

Historical Perspective

To browse the historical perspective of COVID-19, Click here.

Classification

  • COVID-19-associated arrhythmia may be classified into two subtypes/groups based on the clinical presentation:
COVID-19 patients with inherited arrhythmia syndromes are believed to be more liable to pro-arrhythmic consequences of SARS-CoV-2 such as stress, fever, use of antiviral medications and electrolyte disturbance.[6] which includes:

Pathophysiology


To browse the pathophysiology of COVID-19, Click here.

Causes

SARS-CoV-2 causes COVID-19-associated arrhythmia through different mechanisms, including direct viral attack, cytokine storm, etc.

Common causes of arrhythmia include:

Differentiating COVID-19-associated arrhythmia from other Diseases

COVID-19-associated arrhythmia and conduction system disease must be differentiated from other diseases that cause arrhythmia, such as:

Epidemiology and Demographics

  • According to the available data on COVID-19-associated arrhythmia, the prevalence of arrhythmias and conduction system disease in patients with COVID-19 varies from population to population. The incidence of COVID-19-associated arrhythmia and conduction system disease in asymptomatic, mildly ill, critically ill, and recovered patients is not known.[3]
  • According to a cohort of 137 COVID-19 patients from Hubei province, 10 patients were reported to have palpitations as one of the earliest symptoms.[5]
  • In a cohort of 138 COVID-19 patients from Wuhan, arrhythmias were observed in 17 percent of hospitalized patients because of COVID-19-related pneumonia, and in 44 percent of patients admitted to an intensive care unit.[2]
  • One-third of patients with the severe disease also reported other symptoms including arrhythmia. According to a study done in Wuhan, China, 16.7% of hospitalized and 44.4% of ICU patients with COVID-19 had arrhythmias.[14]

Age

  • The prevalence of arrhythmia and Atrial Fibrillation increases with age.[15]

Gender

  • There is not much data available to delineate the gender of COVID-19 patients prone to develop arrhythmia.

Race

  • There is not enough data on a racial predilection for COVID-19-associated arrhythmia.

To browse the epidemiology and demographics of COVID-19, Click here.

Risk Factors

  • To browse the risk factors of COVID-19 click here.

Screening

According to the National Heart, Lung, and Blood Institute, screening for arrhythmia is based on risk factors, such as age or family history.[13]

Electrocardiogram:

  • An electrocardiogram (EKG or ECG) is the main test for detecting arrhythmia.
  • An EKG records the heart’s electrical activity. The doctor may do the test while you are at rest or may do a stress test, which records the heart’s activity when it is working hard.
  • The doctor may also give a portable monitor to wear for a day or several days if no arrhythmia was detected during testing in the clinic. If there is a child who is at risk of arrhythmia because of a genetic condition, the doctor may recommend regular testing for the child and his or her siblings.

Genetic Testing:

  • Genetic testing can help understand the risk when a family member has been diagnosed with a genetic condition. Testing is especially important if the newborn or another close relative died suddenly and had a genetic risk.
  • The doctor may also suggest genetic testing if there is a history of fainting or have survived cardiac arrest or near-drowning.

Imaging tests:

Natural History, Complications and Prognosis

Natural History:

Complications

Arrhythmias that are unrecognized or left untreated can cause sometimes life-threatening complications affecting the heart and brain.[13]

Prognosis

  • In-hospital death among patients with COVID-19-associated arrhythmia and conduction system disease is 4.3% according to a study by Wang et al[14] and 23% among COVID-19 patients who develop Ventricular fibrillation and Ventricular tachycardia according to a study by Guo et al [21] . According to the data available, the Arrhythmia rate is more frequent in Intensive care unit (ICU) patients.[14]

To browse COVID-19 history, complications, and prognosis, Click here.

Diagnosis

Diagnostic Study of Choice

  • ECG:
Most patients with the severe COVID-19, and especially patients who receive QT-prolonging medications, should have a baseline electrocardiogram (ECG) performed at the time of admission to the hospital.The best technique to get the QT interval is with a 12-lead electrocardiogram (ECG). However, to scale back exposure to hospital workers, this could not perpetually be possible. A single-lead ECG might underestimate the QT interval, and there ought to be an effort to use a multiple-lead telemetry system to observe the QT interval.[22][23]
  • Transthoracic echocardiography:
Transthoracic echocardiography is recommended for an inpatient with heart failure, arrhythmia, ECG changes, or newly diagnosed cardiomegaly on chest x-ray or CT-chest.[24]

To browse the diagnostic study of choice of COVID-19, Click here.

History and Symptoms

Arrhythmia or conduction system disease is the nonspecific clinical presentation of COVID-19. Patients may be tachycardic (with or without palpitations) in the setting of other COVID-19-related symptoms (eg, fever, shortness of breath, pain, etc).

  • According to a study done in Hubei province,palpitations were reported as a presenting symptom by 7.3 percent of patients.[5][9]
  • To browse the history and symptoms of COVID-19, Click here.

Physical Examination

Laboratory Findings

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Electrocardiogram

COVID-19-associated arrhythmia findings include:

  • Prolong QT Interval:
According to a multicenter study done in New York that involved 4250 COVID-19 patients, 260 patients (6.1 percent) had corrected QT interval (QTc) >500 milliseconds at the time of admittance. However, in another study that involved 84 patients who got hydroxychloroquine and azithromycin, the baseline QTc interval was 435 milliseconds before receiving these medications.[27][28]
  • Atrial Arrhythmia:
According to a study, among 393 patients with COVID-19, atrial arrhythmias were more common among patients requiring invasive mechanical ventilation than noninvasive mechanical ventilation (17.7 versus 1.9 percent).[29]
  • Ventricular Arrhythmia:
According to a study done in Wuhan, China. among 187 hospitalized patients with COVID-19, 11 patients (5.9 percent) developed ventricular tachyarrhythmias.[30]
  • Cardiac Arrest:
According to a Lombardia Cardiac Arrest Registry (Lombardia CARe) of the region Lombardia in Italy. Out of 9806 cases of COVID-19, 362 cases of out-of-hospital cardiac arrest were reported during the study time frame in 2020. During a similar period in 2019, 229 cases of out-of-hospital cardiac arrest were reported, which means an increment of 58% was observed in 2020 among COVID-19 patients. According to the records from a tertiary care hospital in Wuhan. Out of 761 patients with severe COVID-19, 151 patients developed in-hospital cardiac arrest. 136 patients received resuscitation. Out of 136 patients, 119 patients had a respiratory cause. 10 patients had a cardiac cause. 7 patients had other causes. Ventricular fibrillation or pulseless ventricular tachycardia was observed in 8 patients (5.9%), Pulseless electrical activity in 6 patients (4.4%), and asystole in 122 COVID-19 patients (89.7%).[31][32]
  • To browse the electrocardiogram findings of COVID-19, Click here.

X-Ray

  • To browse the X-ray finding of COVID-19, Click here.

Echocardiography/Ultrasound

CT Scan

  • To browse the CT-Scan findings of COVID-19, Click here.

MRI

Other Imaging Findings

  • There are no other imaging findings associated with COVID-19-associated arrhythmia.

Other Diagnostic Studies

Treatment

Medical Therapy

  • Polymorphic Ventricular Tachycardia (torsades de pointes):
All patients with torsades de pointes (TdP) should be determined if they are hemodynamically stable or unstable through immediate evaluation of the symptoms, vital signs, and level of consciousness.[35]
  • Unstable patients: Patients with COVID-19 with sustained torsades de pointes (TdP) usually become hemodynamically unstable, severely symptomatic because of perfusion failure, or pulseless and should be treated according to standard resuscitation algorithms, including cardioversion/defibrillation. Initial treatment with antiarrhythmic medications is not indicated for hemodynamically unstable or pulseless patients except intravenous (IV) magnesium.
  • Stable patients: In a patient with a single episode of TdP, treatment with IV magnesium along with correction of metabolic/electrolyte disturbances or removal of any inciting medications may be sufficient. The patient should be kept under observation until the electrolytes, and the QT interval nearly normalizes. An IV bolus of 2-gram magnesium sulfate is the standard therapy for an adult. This is equivalent to a dose of 8.12 mmol of magnesium. The clinical situation of a patient determines the rate of magnesium infusion. Infusion occurs over one to two minutes in patients with pulseless cardiac arrest. The infusion should occur over 15 minutes in patients without cardiac arrest as a rapid IV bolus of magnesium can result in hypotension and asystole. Some patients are given a continuous bolus of IV magnesium at a rate of 3 to 20 mg/min until the QT interval is below 0.50 seconds.[36][37]
  • Other Cardiac arrhythmia:
The treatment for other arrhythmias in COVID-19 patients is the same as in patients with arrhythmias without COVID-19 infection. To browse the treatment of other arrhythmias, Click here.

Some medicines are used in combination with each other or together with a procedure or a pacemaker. If the dose is too high, medicines to treat arrhythmia can cause an irregular rhythm. This happens more often in women.[13]

  • Adenosine to slow a racing heart. Adenosine acts quickly to slow electrical signals. It can cause some chest pain, flushing, and shortness of breath, but any discomfort typically passes soon.
  • Atropine to treat a slow heart rate. This medicine may cause difficulty swallowing.
  • Beta-blockers to treat high blood pressure or a fast heart rate or to prevent repeat episodes of arrhythmia. Beta blockers can cause digestive trouble, sleep problems, and sexual dysfunction and can make some conduction disorders worse.
  • Blood thinners to reduce the risk of blood clots forming. This helps prevent stroke. With blood-thinning medicines, there is a risk of bleeding.
  • Calcium channel blockers to slow a rapid heart rate or the speed at which signals travel. Typically, they are used to control arrhythmias of the upper chambers. In some cases, calcium channel blockers can trigger ventricular fibrillation. They can also cause digestive trouble, swollen feet, or low blood pressure.
  • Digitalis, or digoxin, to treat a fast heart rate. This medicine can cause nausea and may trigger arrhythmias.
  • Potassium channel blockers to slow the heart rate. They work by lengthening the time it takes for heart cells to recover after firing, so that they do not fire and squeeze as often. Potassium channel blockers can cause low blood pressure or other arrhythmias.
  • Sodium channel blockers to block transmission of electrical signals, lengthen cell recovery periods, and make cells less excitable. However, these drugs can increase risks of sudden cardiac arrest in people who have heart disease.[13]
  • To browse the medical therapy of COVID-19, click here.

Surgery

  • Surgery is usually the treatment recommended only if all other options have failed. In this case, a person is put under anesthesia and a surgeon removes the tissue causing the arrhythmia.[38]
  • To have a better insight of treatment for different types of arrhythmia, Click here.

Primary Prevention

  • American Heart Association (AHA) recommends the following change in lifestyle:
    • Reduce high blood pressure
    • Control cholesterol levels
    • Lose excess weight
    • Have a heart-healthy diet
    • Stop smoking and avoid secondhand smoke.
    • Do regular physical activity
    • Drink alcohol only in moderation
  • To browse the primary prevention of COVID-19, Click here.

Secondary Prevention

  • To browse the secondary prevention of COVID-19, Click here.

References

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