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{{Infobox_gene}}
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'''cAMP-dependent protein kinase catalytic subunit beta''' is an [[enzyme]] that in humans is encoded by the ''PRKACB'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRKACB protein kinase, cAMP-dependent, catalytic, beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5567| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_PRKACB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1apm.
| PDB = {{PDB2|1apm}}, {{PDB2|1atp}}, {{PDB2|1bkx}}, {{PDB2|1bx6}}, {{PDB2|1cdk}}, {{PDB2|1cmk}}, {{PDB2|1ctp}}, {{PDB2|1fmo}}, {{PDB2|1j3h}}, {{PDB2|1jbp}}, {{PDB2|1jlu}}, {{PDB2|1l3r}}, {{PDB2|1q24}}, {{PDB2|1q61}}, {{PDB2|1q62}}, {{PDB2|1q8t}}, {{PDB2|1q8u}}, {{PDB2|1q8w}}, {{PDB2|1rdq}}, {{PDB2|1re8}}, {{PDB2|1rej}}, {{PDB2|1rek}}, {{PDB2|1smh}}, {{PDB2|1stc}}, {{PDB2|1sve}}, {{PDB2|1svg}}, {{PDB2|1svh}}, {{PDB2|1syk}}, {{PDB2|1szm}}, {{PDB2|1u7e}}, {{PDB2|1veb}}, {{PDB2|1xh4}}, {{PDB2|1xh5}}, {{PDB2|1xh6}}, {{PDB2|1xh7}}, {{PDB2|1xh8}}, {{PDB2|1xh9}}, {{PDB2|1xha}}, {{PDB2|1ydr}}, {{PDB2|1yds}}, {{PDB2|1ydt}}, {{PDB2|2c1a}}, {{PDB2|2c1b}}, {{PDB2|2cpk}}, {{PDB2|2erz}}, {{PDB2|2f7e}}, {{PDB2|2f7x}}, {{PDB2|2f7z}}, {{PDB2|2gfc}}, {{PDB2|2gnf}}, {{PDB2|2gng}}, {{PDB2|2gnh}}, {{PDB2|2gni}}, {{PDB2|2gnj}}, {{PDB2|2gnl}}, {{PDB2|2gu8}}, {{PDB2|2jds}}, {{PDB2|2jdt}}, {{PDB2|2jdv}}, {{PDB2|2oh0}}, {{PDB2|2ojf}}, {{PDB2|2uvx}}, {{PDB2|2uvy}}, {{PDB2|2uvz}}, {{PDB2|2uw0}}, {{PDB2|2uw3}}, {{PDB2|2uw4}}, {{PDB2|2uw5}}, {{PDB2|2uw6}}, {{PDB2|2uw7}}, {{PDB2|2uw8}}, {{PDB2|2uzt}}, {{PDB2|2uzu}}, {{PDB2|2uzv}}, {{PDB2|2uzw}}
| Name = Protein kinase, cAMP-dependent, catalytic, beta
| HGNCid = 9381
| Symbol = PRKACB
| AltSymbols =; DKFZp781I2452; MGC41879; MGC9320; PKACB
| OMIM = 176892
| ECnumber = 
| Homologene = 55518
| MGIid = 97594
| GeneAtlas_image1 = PBB_GE_PRKACB_202742_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PRKACB_202741_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004691 |text = cAMP-dependent protein kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005952 |text = cAMP-dependent protein kinase complex}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007188 |text = G-protein signaling, coupled to cAMP nucleotide second messenger}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5567
    | Hs_Ensembl = ENSG00000142875
    | Hs_RefseqProtein = NP_002722
    | Hs_RefseqmRNA = NM_002731
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 84316329
    | Hs_GenLoc_end = 84476769
    | Hs_Uniprot = P22694
    | Mm_EntrezGene = 18749
    | Mm_Ensembl = ENSMUSG00000005034
    | Mm_RefseqmRNA = NM_011100
    | Mm_RefseqProtein = NP_035230
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 146666960
    | Mm_GenLoc_end = 146750346
    | Mm_Uniprot = Q8C4J3
  }}
}}
'''Protein kinase, cAMP-dependent, catalytic, beta''', also known as '''PRKACB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRKACB protein kinase, cAMP-dependent, catalytic, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5567| accessdate = }}</ref>


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{{PBB_Summary
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| section_title =  
| section_title =  
| summary_text = cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of AMPK. Three alternatively spliced transcript variants encoding distinct isoforms have been observed.<ref name="entrez">{{cite web | title = Entrez Gene: PRKACB protein kinase, cAMP-dependent, catalytic, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5567| accessdate = }}</ref>
| summary_text = cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the [[protein kinase A]] (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of PKA. Three alternatively spliced transcript variants encoding distinct isoforms have been observed.<ref name="entrez" />
}}
}}
==Interactions==
PRKACB has been shown to [[Protein-protein interaction|interact]] with [[Ryanodine receptor 2]]<ref name=pmid10830164>{{cite journal |doi=10.1016/S0092-8674(00)80847-8 |last=Marx |first=S O |authorlink= |author2=Reiken S |author3=Hisamatsu Y |author4=Jayaraman T |author5=Burkhoff D |author6=Rosemblit N |author7=Marks A R  |date=May 2000 |title=PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts |journal=Cell |volume=101 |issue=4 |pages=365–76 |publisher= |location = UNITED STATES| issn = 0092-8674| pmid = 10830164 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[Low affinity nerve growth factor receptor]].<ref name=pmid12682012>{{cite journal |last=Higuchi |first=Haruhisa |authorlink= |author2=Yamashita Toshihide |author3=Yoshikawa Hideki |author4=Tohyama Masaya  |date=April 2003  |title=PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts |journal=EMBO J. |volume=22 |issue=8 |pages=1790–800 |publisher= |location = England| issn = 0261-4189| pmid = 12682012 |doi = 10.1093/emboj/cdg177 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=154469 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Simard J, Bérubé D, Sandberg M, ''et al.'' |title=Assignment of the gene encoding the catalytic subunit C beta of cAMP-dependent protein kinase to the p36 band on chromosome 1. |journal=Hum. Genet. |volume=88 |issue= 6 |pages= 653-7 |year= 1992 |pmid= 1551670 |doi=  }}
*{{cite journal   |vauthors=Simard J, Bérubé D, Sandberg M, etal |title=Assignment of the gene encoding the catalytic subunit C beta of cAMP-dependent protein kinase to the p36 band on chromosome 1. |journal=Hum. Genet. |volume=88 |issue= 6 |pages= 653–7 |year= 1992 |pmid= 1551670 |doi=10.1007/BF02265292 }}
*{{cite journal | author=Hofmann B, Nishanian P, Baldwin RL, ''et al.'' |title=HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism. |journal=J. Immunol. |volume=145 |issue= 11 |pages= 3699-705 |year= 1991 |pmid= 1978848 |doi=  }}
*{{cite journal   |vauthors=Hofmann B, Nishanian P, Baldwin RL, etal |title=HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism. |journal=J. Immunol. |volume=145 |issue= 11 |pages= 3699–705 |year= 1991 |pmid= 1978848 |doi=  }}
*{{cite journal | author=Beebe SJ, Oyen O, Sandberg M, ''et al.'' |title=Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. |journal=Mol. Endocrinol. |volume=4 |issue= 3 |pages= 465-75 |year= 1990 |pmid= 2342480 |doi=  }}
*{{cite journal   |vauthors=Beebe SJ, Oyen O, Sandberg M, etal |title=Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. |journal=Mol. Endocrinol. |volume=4 |issue= 3 |pages= 465–75 |year= 1990 |pmid= 2342480 |doi=10.1210/mend-4-3-465 }}
*{{cite journal  | author=Scarpetta MA, Uhler MD |title=Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse. |journal=J. Biol. Chem. |volume=268 |issue= 15 |pages= 10927-31 |year= 1993 |pmid= 7684369 |doi=  }}
*{{cite journal  |vauthors=Scarpetta MA, Uhler MD |title=Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse. |journal=J. Biol. Chem. |volume=268 |issue= 15 |pages= 10927–31 |year= 1993 |pmid= 7684369 |doi=  }}
*{{cite journal | author=Hofmann B, Nishanian P, Nguyen T, ''et al.'' |title=Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6676-80 |year= 1993 |pmid= 7688126 |doi=  }}
*{{cite journal   |vauthors=Hofmann B, Nishanian P, Nguyen T, etal |title=Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6676–80 |year= 1993 |pmid= 7688126 |doi=10.1073/pnas.90.14.6676  | pmc=46995 }}
*{{cite journal | author=Hofmann B, Nishanian P, Fan J, ''et al.'' |title=HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro. |journal=AIDS |volume=8 |issue= 7 |pages= 1016-7 |year= 1994 |pmid= 7946090 |doi= }}
*{{cite journal   |vauthors=Hofmann B, Nishanian P, Fan J, etal |title=HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro. |journal=AIDS |volume=8 |issue= 7 |pages= 1016–7 |year= 1994 |pmid= 7946090 |doi=10.1097/00002030-199407000-00025  }}
*{{cite journal  | author=Gamm DM, Baude EJ, Uhler MD |title=The major catalytic subunit isoforms of cAMP-dependent protein kinase have distinct biochemical properties in vitro and in vivo. |journal=J. Biol. Chem. |volume=271 |issue= 26 |pages= 15736-42 |year= 1996 |pmid= 8662989 |doi=  }}
*{{cite journal  |vauthors=Gamm DM, Baude EJ, Uhler MD |title=The major catalytic subunit isoforms of cAMP-dependent protein kinase have distinct biochemical properties in vitro and in vivo. |journal=J. Biol. Chem. |volume=271 |issue= 26 |pages= 15736–42 |year= 1996 |pmid= 8662989 |doi=10.1074/jbc.271.26.15736 }}
*{{cite journal | author=Swingler S, Gallay P, Camaur D, ''et al.'' |title=The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix. |journal=J. Virol. |volume=71 |issue= 6 |pages= 4372-7 |year= 1997 |pmid= 9151826 |doi=  }}
*{{cite journal   |vauthors=Swingler S, Gallay P, Camaur D, etal |title=The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix. |journal=J. Virol. |volume=71 |issue= 6 |pages= 4372–7 |year= 1997 |pmid= 9151826 |doi= | pmc=191654 }}
*{{cite journal  | author=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385-8 |year= 1997 |pmid= 9278385 |doi=  }}
*{{cite journal  |vauthors=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385–8 |year= 1997 |pmid= 9278385 |doi=10.1074/jbc.272.36.22385 }}
*{{cite journal | author=Liapi C, Takahashi N, Raynaud F, ''et al.'' |title=Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts. |journal=J. Invest. Dermatol. |volume=110 |issue= 4 |pages= 332-7 |year= 1998 |pmid= 9540970 |doi= 10.1046/j.1523-1747.1998.00149.x }}
*{{cite journal   |vauthors=Liapi C, Takahashi N, Raynaud F, etal |title=Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts. |journal=J. Invest. Dermatol. |volume=110 |issue= 4 |pages= 332–7 |year= 1998 |pmid= 9540970 |doi= 10.1046/j.1523-1747.1998.00149.x }}
*{{cite journal  | author=Rabbi MF, al-Harthi L, Saifuddin M, Roebuck KA |title=The cAMP-dependent protein kinase A and protein kinase C-beta pathways synergistically interact to activate HIV-1 transcription in latently infected cells of monocyte/macrophage lineage. |journal=Virology |volume=245 |issue= 2 |pages= 257-69 |year= 1998 |pmid= 9636365 |doi= 10.1006/viro.1998.9158 }}
*{{cite journal  |vauthors=Rabbi MF, al-Harthi L, Saifuddin M, Roebuck KA |title=The cAMP-dependent protein kinase A and protein kinase C-beta pathways synergistically interact to activate HIV-1 transcription in latently infected cells of monocyte/macrophage lineage. |journal=Virology |volume=245 |issue= 2 |pages= 257–69 |year= 1998 |pmid= 9636365 |doi= 10.1006/viro.1998.9158 }}
*{{cite journal | author=Zidovetzki R, Wang JL, Chen P, ''et al.'' |title=Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways. |journal=AIDS Res. Hum. Retroviruses |volume=14 |issue= 10 |pages= 825-33 |year= 1998 |pmid= 9671211 |doi= }}
*{{cite journal   |vauthors=Zidovetzki R, Wang JL, Chen P, etal |title=Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways. |journal=AIDS Res. Hum. Retroviruses |volume=14 |issue= 10 |pages= 825–33 |year= 1998 |pmid= 9671211 |doi=10.1089/aid.1998.14.825  }}
*{{cite journal | author=Mayne M, Bratanich AC, Chen P, ''et al.'' |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184-92 |year= 1998 |pmid= 9730685 |doi=  }}
*{{cite journal   |vauthors=Mayne M, Bratanich AC, Chen P, etal |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184–92 |year= 1998 |pmid= 9730685 |doi=10.1159/000026336 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Jiang CH, Tsien JZ, Schultz PG, Hu Y |title=The effects of aging on gene expression in the hypothalamus and cortex of mice. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 4 |pages= 1930-4 |year= 2001 |pmid= 11172053 |doi= 10.1073/pnas.98.4.1930 }}
*{{cite journal  |vauthors=Jiang CH, Tsien JZ, Schultz PG, Hu Y |title=The effects of aging on gene expression in the hypothalamus and cortex of mice. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 4 |pages= 1930–4 |year= 2001 |pmid= 11172053 |doi= 10.1073/pnas.98.4.1930 | pmc=29359 }}
*{{cite journal | author=Ørstavik S, Reinton N, Frengen E, ''et al.'' |title=Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase. |journal=Eur. J. Biochem. |volume=268 |issue= 19 |pages= 5066-73 |year= 2001 |pmid= 11589697 |doi=  }}
*{{cite journal   |vauthors=Ørstavik S, Reinton N, Frengen E, etal |title=Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase. |journal=Eur. J. Biochem. |volume=268 |issue= 19 |pages= 5066–73 |year= 2001 |pmid= 11589697 |doi=10.1046/j.0014-2956.2001.02429.x }}
*{{cite journal  | author=Wu KJ, Mattioli M, Morse HC, Dalla-Favera R |title=c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cbeta) gene. |journal=Oncogene |volume=21 |issue= 51 |pages= 7872-82 |year= 2002 |pmid= 12420224 |doi= 10.1038/sj.onc.1205986 }}
*{{cite journal  |vauthors=Wu KJ, Mattioli M, Morse HC, Dalla-Favera R |title=c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cbeta) gene. |journal=Oncogene |volume=21 |issue= 51 |pages= 7872–82 |year= 2002 |pmid= 12420224 |doi= 10.1038/sj.onc.1205986 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Higuchi H, Yamashita T, Yoshikawa H, Tohyama M |title=PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts. |journal=EMBO J. |volume=22 |issue= 8 |pages= 1790-800 |year= 2003 |pmid= 12682012 |doi= 10.1093/emboj/cdg177 }}
*{{cite journal  |vauthors=Higuchi H, Yamashita T, Yoshikawa H, Tohyama M |title=PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts. |journal=EMBO J. |volume=22 |issue= 8 |pages= 1790–800 |year= 2003 |pmid= 12682012 |doi= 10.1093/emboj/cdg177 | pmc=154469 }}
*{{cite journal | author=Gassel M, Breitenlechner CB, Rüger P, ''et al.'' |title=Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT). |journal=J. Mol. Biol. |volume=329 |issue= 5 |pages= 1021-34 |year= 2003 |pmid= 12798691 |doi=  }}
*{{cite journal   |vauthors=Gassel M, Breitenlechner CB, Rüger P, etal |title=Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT). |journal=J. Mol. Biol. |volume=329 |issue= 5 |pages= 1021–34 |year= 2003 |pmid= 12798691 |doi=10.1016/S0022-2836(03)00518-7 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=5567}}
{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
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[[Category:EC 2.7.11]]


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Revision as of 18:41, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

cAMP-dependent protein kinase catalytic subunit beta is an enzyme that in humans is encoded by the PRKACB gene.[1]

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the protein kinase A (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of PKA. Three alternatively spliced transcript variants encoding distinct isoforms have been observed.[1]

Interactions

PRKACB has been shown to interact with Ryanodine receptor 2[2] and Low affinity nerve growth factor receptor.[3]

References

  1. ↑ 1.0 1.1 "Entrez Gene: PRKACB protein kinase, cAMP-dependent, catalytic, beta".
  2. ↑ Marx, S O; Reiken S; Hisamatsu Y; Jayaraman T; Burkhoff D; Rosemblit N; Marks A R (May 2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts". Cell. UNITED STATES. 101 (4): 365–76. doi:10.1016/S0092-8674(00)80847-8. ISSN 0092-8674. PMID 10830164.
  3. ↑ Higuchi, Haruhisa; Yamashita Toshihide; Yoshikawa Hideki; Tohyama Masaya (April 2003). "PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts". EMBO J. England. 22 (8): 1790–800. doi:10.1093/emboj/cdg177. ISSN 0261-4189. PMC 154469. PMID 12682012.

Further reading


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