Differentiating Antiphospholipid syndrome from other diseases: Difference between revisions

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Revision as of 15:54, 24 April 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Antiphospholipid syndrome should be differentiated from conditions such as hemolytic uremic syndrome-thrombotic thrombocytopenic purpura (HUS-TTP), disseminated intravascular coagulation (DIC), and vasculitis .

Differentiating Antiphospholipid antibody syndrome from other Diseases

Hemolytic uremic syndrome-Thrombotic thrombocytopenic purpura (HUS-TTP)
Disseminated Intravascular Coagulation (DIC)
Vasculitis
Embolic disease
Cryoglobulinemia
Calciphylaxis

Abbreviations: ABG= Arterial blood gas, ANA= Antinuclear antibody, ANP= Atrial natriuretic peptide, ASO= Antistreptolysin O antibody, BNP= Brain natriuretic peptide, CBC= Complete blood count, COPD= Chronic obstructive pulmonary disease, CRP= C-reactive protein, CT= Computed tomography, CXR= Chest X-ray, DVT= Deep vein thrombosis, ESR= Erythrocyte sedimentation rate, HRCT= High Resolution CT, IgE= Immunoglobulin E, LDH= Lactate dehydrogenase, PCWP= Pulmonary capillary wedge pressure, PCR= Polymerase chain reaction, PFT= Pulmonary function test.

			Symptoms					Physical examination			Lab Findings				Imaging				Histopathology
Diseases			Clinical manifestations								Para-clinical findings									Gold standard	Additional findings
			Symptoms					Physical examination			Para-clinical findings
			Headache	Fever	Weight loss	Arthralgia	Claudication	Bruit	HTN	Focal neurological disorder	Biomarker	CBC	ESR	Other	CT scan	Angiography	Ultrasound/ Echocardiography	Other	Histopathology
Medium-Vessel Vasculitis	Polyarteritis nodosa^[1]		+	+	+	+	+	+	+/-	+/-	LAMP-2 protein autoantibodies	Leukocytosis, Normochromic anemia, Thrombocytosis	↑	↑ Cr or BUN, ↑ ALT or AST, Proteinuria	Focal regions of infarction or hemorrhage	Multiple microaneurysms, Hemorrhage due to focal rupture, Occlusion	Aneurysms and renal arteriovenous fistula in color Doppler sonography	-	Necrotizing inflammatory lesions	Angiography	Sudden weight loss, Abdominal pain
	Hepatitis B virus-associated polyarteritis nodosa^[2]		+/-	+/-	+	+	+/-	+/-	+	-	HBsAg	Leukocytosis, Normochromic anemia, Thrombocytosis	↑	↑ ALT or AST	Focal regions of infarction or hemorrhage	Microaneurysms in mesenteric artery	Aneurysms and renal arteriovenous fistula in color Doppler sonography	-	Necrotizing inflammatory lesions	Angiography	Peripheral neuropathy, Livedo reticularis
	Kawasaki disease^[3]		-	+	+/-	+	+	-	+/-	-	NT-proBNP, Meprin A, Filamin C	Normochromic anemia, ↑WBC with a left shift, Thrombocytosis	↑	Acute-phase reactants, ↓Cholesterol, ↓HDL, ↓ApolipoA	Coronary artery calcifications	Coronary artery aneurysms, stenosis or occlusion	Coronary artery anomaly in echocardiography	Electron beam CT (EBCT)	Acute destruction of the media by neutrophils, with loss of elastic fibers	History and physical examination	Diarrhea, Vomiting
	Infectious disease	Parvovirus B19 infection^[4]	+	+	+	+	-	-	-	+/-	B19 DNA, ↓Reticulocyte count	Anemia	↑	anti–parvovirus B19 IgM	-	-	Hydrops in fetal ultrasonography	-	-	B19 DNA	Purpuric rash, Erythema multiforme
		Scarlet fever^[5]	+	+	+/-	+	-	-	-	-	Antistreptolysin-O (ASO) titers	Leukocytosis	↑	↑CRP	Thickened pulmonary markings if pneumonia	-	-	-	Sparse neutrophilic perivascular infiltrate	History and physical examination	Sand-paper rashes, Sore throat
		Toxic shock syndrome^[6]	+	+	+	+	-	-	-	+/-	Procalcitonin	Leukocytosis with left shift	↑	Myoglobinuria, Sterile pyuria	Acute respiratory distress syndrome	-	-	-	Necrolysis of keratinocytes in epidermis, Perivascular lymphocytic infiltrate	Clinical criteria	Peeling or rashes, Organ dysfunction
		Mononucleosis^[7]	+	+	+	+	-	-	-	-	EBV DNA	Atypical lymphocyte	↑	Heterophile antibodies	CNS involvement	-	Splenomegaly	Encephalitis in MRI	Lymphoproliferative response in oropharynx, Lymphocytic infiltration in spleen	Heterophile antibody test	Splenomegaly, Palatal petechiae
		Leptospirosis^[8]	+	+	+	+	+/-	-	-	-	IL-6, IL-8 and IL-10	Anemia	-	↑Cr or BUN, ↑ALT or AST, Proteinuria	Diffuse alveolar hemorrhage	-	-	-	Toxin-mediated break down of endothelial cell membranes of capillaries	Culture and the microscopic agglutination test	Red eyes, Skin rash
		Lyme Disease^[9]	+/-	+	+/-	+	+/-	-	-	-	CXCL9 (MIG), CXCL10 (IP-10) and CCL19 (MIP3B)	Leukopenia, Thrombocytopenia	-	Microscopic hematuria, Proteinuria, ↑ALT or AST	Punctate lesions in periventricular white matter in brain SPECT	-	-	-	Acrodermatitis chronica atrophicans	Serologic tests	Erythema migrans
		Measles^[10]	+/-	+	+/-	+	-	-	-	-	Measles IgM	Leukopenia, Lymphocytosis, Thrombocytopenia	-	↑ALT or AST	Pneumonia	-	-	CXR	Spongiosis and vesiculation in the epidermis with scattered dyskeratotic keratinocytes	PCR	Generalized rash, Cough, Coryza, or Conjunctivitis
		Rocky Mountain Spotted Fever^[11]	+	+	+	+	-	-	-	-	R rickettsii serology	Thrombocytopenia, Anemia	-	↑ALT or AST, Hyponatremia	Infarction, edema, and meningeal enhancement	-	Myocardial or conduction abnormalities in echocardiography	-	Immunofluorescent or immunoperoxidase staining of R rickettsii	Clinical criteria and tick exposure	Rash on the palms and soles
		Staphylococcal Scalded Skin Syndrome^[12]	+	+	+	+	-	-	+/-	+/-	Anti exfoliatin and anti alpha-toxin antibodies	Leukocytosis with left shift	↑	Blood culture	Pneumonia	-	-	-	Intraepidermal blister, dense superficial perivascular lymphohistiocytic infiltrate	Blood culture and clinical findings	Widespread skin erythema, fluid-filled blisters
		Toxic Epidermal Necrolysis^[13]	-	+	+	-	-	-	-	+/-	MicroRNA-124	Normochromic normocytic anemia, Eosinophilia	↑	Fluid loss and electrolyte abnormalities	Tracheobronchial inflammation	-	-	-	Necrotic keratinocytes with full-thickness epithelial necrosis	Histopathology and clinical findings	Erythematous macular rash with purpuric centers
	Cardiovascular disease	Atrial Myxoma^[14]	-	-	+/-	-	-	-	-	+/-	Calretinin	Mild anemia, Leukocytosis	↑	↑IL-6	Atrial filling defect larger than a thrombus	-	Tumor location, size, attachment, and mobility in echocardiography	Size, shape, and surface characteristics in MRI	Lipidic cells embedded in a vascular myxoid stroma	Echocardiography	Dyspnea on exertion, Syncope
		Cholesterol Embolism^[15]	+/-	+/-	-	-	+	-	-	+	IL-5	Eosinophilia, Leukocytosis	↑	Eosinophiluria	Thoracic and abdominal aortic sources of embolism	Atheroembolism in abdominal aorta and the lower extremity arteries	Excluding an intracardiac source of embolism with echocardiography	-	Birefringent crystals or biconvex needle-shaped ghostly clefts within the arterial lumen	Angiography	Livedo reticularis, Ischemic patches
		Segmental arterial mediolysis^[16]	+	-	-	-	+	+	+	+/-	-	Leukocytosis	-	-	Visceral artery aneurysm in CT angiography	Alternating aneurysms and stenoses (beading)	Retroperitoneal hematoma	-	Disruption of the smooth muscle in the media	Angiography	Hematuria, Ischemic colitis
	Systemic disease	Antiphospholipid Syndrome^[17]	+	+	-	-	-	-	-	+/-	Antiphospholipid antibodies	Thrombocytopenia, Hemolytic anemia	-	Lupus anticoagulant (LA)	Stroke, Pulmonary embolism, Budd-Chiari syndrome	Thrombus in major vessels	Valve thickening, vegetations, or insufficiency in echocardiography	-	Noninflammatory bland thrombosis without perivascular inflammation	Hx of thrombosis and antiphospholipid antibodies	Miscarriage, Pulmonary hypertension
	Systemic disease	Juvenile Idiopathic Arthritis^[18]	-	-	-	+	+/-	-	-	-	Rheumatoid factor (RF), S100A12	Lymphocytosis, Thrombocytopenia	↑	Myeloid-related proteins 8/14 (MRP8/14)	Synovial hypertrophy, Joint effusions	Cerebral vasculitis	Inflamed synovium	Bone scanning	Vascular congestion, RBC extravasation, Venular lumen occlusion	Conventional radiography	Evanescent rash, Dactylitis

References

↑ Howard T, Ahmad K, Swanson JA, Misra S (2014). "Polyarteritis nodosa". Tech Vasc Interv Radiol. 17 (4): 247–51. doi:10.1053/j.tvir.2014.11.005. PMC 4363102. PMID 25770638.
↑ Sharma A, Sharma K (September 2013). "Hepatotropic viral infection associated systemic vasculitides-hepatitis B virus associated polyarteritis nodosa and hepatitis C virus associated cryoglobulinemic vasculitis". J Clin Exp Hepatol. 3 (3): 204–12. doi:10.1016/j.jceh.2013.06.001. PMC 4216827. PMID 25755502.
↑ Takahashi K, Oharaseki T, Yokouchi Y (2011). "Pathogenesis of Kawasaki disease". Clin Exp Immunol. 164 Suppl 1: 20–2. doi:10.1111/j.1365-2249.2011.04361.x. PMC 3095860. PMID 21447126.
↑ Heegaard ED, Brown KE (2002). "Human parvovirus B19". Clin Microbiol Rev. 15 (3): 485–505. PMC 118081. PMID 12097253.
↑ Basetti S, Hodgson J, Rawson TM, Majeed A (2017). "Scarlet fever: a guide for general practitioners". London J Prim Care (Abingdon). 9 (5): 77–79. doi:10.1080/17571472.2017.1365677. PMC 5649319. PMID 29081840.
↑ Vostral SL (2011). "Rely and Toxic Shock Syndrome: a technological health crisis". Yale J Biol Med. 84 (4): 447–59. PMC 3238331. PMID 22180682.
↑ Balfour HH, Dunmire SK, Hogquist KA (2015). "Infectious mononucleosis". Clin Transl Immunology. 4 (2): e33. doi:10.1038/cti.2015.1. PMC 4346501. PMID 25774295.
↑ Levett PN (April 2001). "Leptospirosis". Clin. Microbiol. Rev. 14 (2): 296–326. doi:10.1128/CMR.14.2.296-326.2001. PMC 88975. PMID 11292640.
↑ Biesiada G, Czepiel J, Leśniak MR, Garlicki A, Mach T (2012). "Lyme disease: review". Arch Med Sci. 8 (6): 978–82. doi:10.5114/aoms.2012.30948. PMC 3542482. PMID 23319969.
↑ White SJ, Boldt KL, Holditch SJ, Poland GA, Jacobson RM (2012). "Measles, mumps, and rubella". Clin Obstet Gynecol. 55 (2): 550–9. doi:10.1097/GRF.0b013e31824df256. PMC 3334858. PMID 22510638.
↑ Walker DH (1989). "Rocky Mountain spotted fever: a disease in need of microbiological concern". Clin Microbiol Rev. 2 (3): 227–40. PMC 358117. PMID 2504480.
↑ Mishra AK, Yadav P, Mishra A (2016). "A Systemic Review on Staphylococcal Scalded Skin Syndrome (SSSS): A Rare and Critical Disease of Neonates". Open Microbiol J. 10: 150–9. doi:10.2174/1874285801610010150. PMC 5012080. PMID 27651848.
↑ Hoetzenecker W, Mehra T, Saulite I, Glatz M, Schmid-Grendelmeier P, Guenova E; et al. (2016). "Toxic epidermal necrolysis". F1000Res. 5. doi:10.12688/f1000research.7574.1. PMC 4879934. PMID 27239294.
↑ MacGowan SW, Sidhu P, Aherne T, Luke D, Wood AE, Neligan MC, McGovern E (June 1993). "Atrial myxoma: national incidence, diagnosis and surgical management". Ir J Med Sci. 162 (6): 223–6. PMID 8407260.
↑ Avci G, Akoz T, Gul AE (2009). "Cutaneous cholesterol embolization". J Dermatol Case Rep. 3 (2): 27–9. doi:10.3315/jdcr.2009.1031. PMC 3157794. PMID 21886725.
↑ Chao, Christine (2009). "Segmental Arterial Mediolysis". Seminars in Interventional Radiology. 26 (03): 224–232. doi:10.1055/s-0029-1225666. ISSN 0739-9529.
↑ Chaturvedi S, McCrae KR (2015). "The antiphospholipid syndrome: still an enigma". Hematology Am Soc Hematol Educ Program. 2015: 53–60. doi:10.1182/asheducation-2015.1.53. PMC 4877624. PMID 26637701.
↑ Espinosa M, Gottlieb BS (July 2012). "Juvenile idiopathic arthritis". Pediatr Rev. 33 (7): 303–13. doi:10.1542/pir.33-7-303. PMID 22753788.

Template:WH Template:WS

[pmid25770638-1] Howard T, Ahmad K, Swanson JA, Misra S (2014). "Polyarteritis nodosa". Tech Vasc Interv Radiol. 17 (4): 247–51. doi:10.1053/j.tvir.2014.11.005. PMC 4363102. PMID 25770638.

[pmid25755502-2] Sharma A, Sharma K (September 2013). "Hepatotropic viral infection associated systemic vasculitides-hepatitis B virus associated polyarteritis nodosa and hepatitis C virus associated cryoglobulinemic vasculitis". J Clin Exp Hepatol. 3 (3): 204–12. doi:10.1016/j.jceh.2013.06.001. PMC 4216827. PMID 25755502.

[pmid21447126-3] Takahashi K, Oharaseki T, Yokouchi Y (2011). "Pathogenesis of Kawasaki disease". Clin Exp Immunol. 164 Suppl 1: 20–2. doi:10.1111/j.1365-2249.2011.04361.x. PMC 3095860. PMID 21447126.

[pmid12097253-4] Heegaard ED, Brown KE (2002). "Human parvovirus B19". Clin Microbiol Rev. 15 (3): 485–505. PMC 118081. PMID 12097253.

[pmid29081840-5] Basetti S, Hodgson J, Rawson TM, Majeed A (2017). "Scarlet fever: a guide for general practitioners". London J Prim Care (Abingdon). 9 (5): 77–79. doi:10.1080/17571472.2017.1365677. PMC 5649319. PMID 29081840.

[pmid22180682-6] Vostral SL (2011). "Rely and Toxic Shock Syndrome: a technological health crisis". Yale J Biol Med. 84 (4): 447–59. PMC 3238331. PMID 22180682.

[pmid25774295-7] Balfour HH, Dunmire SK, Hogquist KA (2015). "Infectious mononucleosis". Clin Transl Immunology. 4 (2): e33. doi:10.1038/cti.2015.1. PMC 4346501. PMID 25774295.

[pmid11292640-8] Levett PN (April 2001). "Leptospirosis". Clin. Microbiol. Rev. 14 (2): 296–326. doi:10.1128/CMR.14.2.296-326.2001. PMC 88975. PMID 11292640.

[pmid23319969-9] Biesiada G, Czepiel J, Leśniak MR, Garlicki A, Mach T (2012). "Lyme disease: review". Arch Med Sci. 8 (6): 978–82. doi:10.5114/aoms.2012.30948. PMC 3542482. PMID 23319969.

[pmid22510638-10] White SJ, Boldt KL, Holditch SJ, Poland GA, Jacobson RM (2012). "Measles, mumps, and rubella". Clin Obstet Gynecol. 55 (2): 550–9. doi:10.1097/GRF.0b013e31824df256. PMC 3334858. PMID 22510638.

[pmid2504480-11] Walker DH (1989). "Rocky Mountain spotted fever: a disease in need of microbiological concern". Clin Microbiol Rev. 2 (3): 227–40. PMC 358117. PMID 2504480.

[pmid27651848-12] Mishra AK, Yadav P, Mishra A (2016). "A Systemic Review on Staphylococcal Scalded Skin Syndrome (SSSS): A Rare and Critical Disease of Neonates". Open Microbiol J. 10: 150–9. doi:10.2174/1874285801610010150. PMC 5012080. PMID 27651848.

[pmid27239294-13] Hoetzenecker W, Mehra T, Saulite I, Glatz M, Schmid-Grendelmeier P, Guenova E; et al. (2016). "Toxic epidermal necrolysis". F1000Res. 5. doi:10.12688/f1000research.7574.1. PMC 4879934. PMID 27239294.

[pmid8407260-14] MacGowan SW, Sidhu P, Aherne T, Luke D, Wood AE, Neligan MC, McGovern E (June 1993). "Atrial myxoma: national incidence, diagnosis and surgical management". Ir J Med Sci. 162 (6): 223–6. PMID 8407260.

[pmid21886725-15] Avci G, Akoz T, Gul AE (2009). "Cutaneous cholesterol embolization". J Dermatol Case Rep. 3 (2): 27–9. doi:10.3315/jdcr.2009.1031. PMC 3157794. PMID 21886725.

[Chao2009-16] Chao, Christine (2009). "Segmental Arterial Mediolysis". Seminars in Interventional Radiology. 26 (03): 224–232. doi:10.1055/s-0029-1225666. ISSN 0739-9529.

[pmid26637701-17] Chaturvedi S, McCrae KR (2015). "The antiphospholipid syndrome: still an enigma". Hematology Am Soc Hematol Educ Program. 2015: 53–60. doi:10.1182/asheducation-2015.1.53. PMC 4877624. PMID 26637701.

[pmid22753788-18] Espinosa M, Gottlieb BS (July 2012). "Juvenile idiopathic arthritis". Pediatr Rev. 33 (7): 303–13. doi:10.1542/pir.33-7-303. PMID 22753788.

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@@ Line 4: / Line 4: @@
 ==Overview==
-Antiphospholipid syndrome needs to be differentiated from conditions such as [[hemolytic uremic syndrome]]-[[thrombotic thrombocytopenic purpura]] (HUS-TTP), [[disseminated intravascular coagulation]] (DIC), and [[vasculitis]] .
+Antiphospholipid syndrome should be differentiated from conditions such as [[hemolytic uremic syndrome]]-[[thrombotic thrombocytopenic purpura]] (HUS-TTP), [[disseminated intravascular coagulation]] (DIC), and [[vasculitis]] .
 ==Differentiating Antiphospholipid antibody syndrome from other Diseases==
@@ Line 13: / Line 13: @@
 * [[Cryoglobulinemia]]
 * [[Calciphylaxis]]
 <span style="font-size:85%">'''Abbreviations:'''
 ABG= [[Arterial blood gas]], ANA= [[Antinuclear antibody]], ANP= [[Atrial natriuretic peptide]], ASO= [[Antistreptolysin O|Antistreptolysin O antibody]], BNP= [[Brain natriuretic peptide]], CBC= [[Complete blood count]], COPD= [[Chronic obstructive pulmonary disease]], CRP= [[C-reactive protein]], CT= [[Computed tomography]], CXR= [[Chest X-ray]], DVT= [[Deep vein thrombosis]], ESR= [[Erythrocyte sedimentation rate]], HRCT= [[High Resolution CT]], IgE= [[Immunoglobulin E]], LDH= [[Lactate dehydrogenase]], PCWP= [[Pulmonary capillary wedge pressure]], PCR= [[Polymerase chain reaction]], PFT= [[Pulmonary function test]].</span>
-<small><small><small>
+<small>
 {| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
 ! colspan="3" rowspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |Diseases
@@ Line 47: / Line 49: @@
 ! style="background:#4479BA; color: #FFFFFF;" align="center" |Ultrasound/ Echocardiography
 ! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
-|-
-! rowspan="9" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Large-Vessel Vasculitis
-! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Takayasu arteritis]]<ref name="pmid23626437">{{cite journal| author=Vaideeswar P, Deshpande JR| title=Pathology of Takayasu arteritis: A brief review. | journal=Ann Pediatr Cardiol | year= 2013 | volume= 6 | issue= 1 | pages= 52-8 | pmid=23626437 | doi=10.4103/0974-2069.107235 | pmc=3634248 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23626437  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[MMP|MMP-3]] and [[Matrix metalloproteinase|MMP-9]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[CRP]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysm|Aneurysmal dilatation]] of the [[aorta]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Blood vessel]] [[stenosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Circumferential thickening of the [[arterial]] wall (Macaroni sign)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[PET scan|PET-scan]], [[Cardiac]] [[CT]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Granulomatous]] [[inflammation]] of [[arteries]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Arteriography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Coronary aneurysm]]
-|-
-! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Giant cell arteritis]]<ref name="pmid13679546">{{cite journal| author=Calvo-Romero JM| title=Giant cell arteritis. | journal=Postgrad Med J | year= 2003 | volume= 79 | issue= 935 | pages= 511-5 | pmid=13679546 | doi= | pmc=1742823 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13679546  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pentraxin|Pentraxin 3 (PTX3)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[CRP]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Stenosis]], [[Occlusion]], [[Dilatation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysm]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mural [[inflammation]] in [[Magnetic resonance angiography|MRA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Granulomatous]] [[inflammation]] of [[arteries]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Biopsy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Jaw pain]] and [[Jaw claudication|claudication]]
-|-
-! rowspan="3" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Neurological disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cerebral aneurysm]]<ref name="pmid20557771">{{cite journal| author=Stafa A, Leonardi M| title=Role of neuroradiology in evaluating cerebral aneurysms. | journal=Interv Neuroradiol | year= 2008 | volume= 14 Suppl 1 | issue=  | pages= 23-37 | pmid=20557771 | doi=10.1177/15910199080140S106 | pmc=3328052 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20557771  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Well-defined round, slightly hyperattenuating lesion
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Bulging out of the [[Lumen|main lumen]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Heterogeneous]] signal intensity in [[Magnetic resonance angiography|MRA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Layers of [[smooth muscle cells]], Intact [[endothelium]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Digital subtraction angiography|Digital subtraction angiography (DSA)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Nausea]], [[Vomiting]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Neurofibromatosis type 1]]<ref name="pmid28512424">{{cite journal| author=Cassiman C, Casteels I, Stalmans P, Legius E, Jacob J| title=Optical Coherence Tomography Angiography of Retinal Microvascular Changes Overlying Choroidal Nodules in Neurofibromatosis Type 1. | journal=Case Rep Ophthalmol | year= 2017 | volume= 8 | issue= 1 | pages= 214-220 | pmid=28512424 | doi=10.1159/000469702 | pmc=5422752 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28512424  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[NF1|NF1 mutated gene]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Neurofibromin|Neurofibromin gene]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bone disease|Bone abnormalities]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Optical coherence tomography angiography (OCTA)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Optic nerve gliomas]] in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Elongated spindle-shaped [[cells]] in [[Neurofibroma|neurofibromas]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[National Institutes of Health|NIH]] [[diagnostic criteria]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Café au lait spot|Cafe au Lait spot]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Neurofibromatosis type 2]]<ref name="Evans2000">{{cite journal|last1=Evans|first1=D G. R|title=Neurofibromatosis type 2|journal=Journal of Medical Genetics|volume=37|issue=12|year=2000|pages=897–904|issn=14686244|doi=10.1136/jmg.37.12.897}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[NF2 gene|NF2 mutated gene]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Merlin (protein)|Schwannomin]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Meningioma]], [[Schwannoma]], [[Ependymoma]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fluorescein angiography]] showed [[retinal]] [[hamartoma]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Localized [[schwannomas]] in nerve [[ultrasound]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Schwannoma]] in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Encapsulated biphasic [[nerve sheath]] [[tumor]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[National Institutes of Health|NIH]] [[diagnostic criteria]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hearing loss]], [[Vision loss]]
-|-
-! rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Fibromuscular dysplasia]]<ref name="pmid17555581">{{cite journal| author=Plouin PF, Perdu J, La Batide-Alanore A, Boutouyrie P, Gimenez-Roqueplo AP, Jeunemaitre X| title=Fibromuscular dysplasia. | journal=Orphanet J Rare Dis | year= 2007 | volume= 2 | issue=  | pages= 28 | pmid=17555581 | doi=10.1186/1750-1172-2-28 | pmc=1899482 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17555581  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Transforming growth factor β|Transforming growth factor β (TGF-β)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑ [[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Alternating [[stenosis]] and [[Dilatation|dilatations]] in [[CT angiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Stenosis]] in the [[renal arteries]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Luminal narrowing alternating with [[dilatation]] (Beads sign)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Focal [[concentric]], long-segment [[tubular]] [[stenosis]] or outpouching in [[MRA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Fibrodysplastic changes, [[Collagen]] deposition
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Digital subtraction angiography|Digital subtraction angiography (DSA)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Spontaneous coronary artery dissection|Spontaneous coronary artery dissection (SCAD)]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Ehlers-Danlos syndrome]]<ref name="pmid27824552">{{cite journal| author=Gazit Y, Jacob G, Grahame R| title=Ehlers-Danlos Syndrome-Hypermobility Type: A Much Neglected Multisystemic Disorder. | journal=Rambam Maimonides Med J | year= 2016 | volume= 7 | issue= 4 | pages=  | pmid=27824552 | doi=10.5041/RMMJ.10261 | pmc=5101008 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27824552  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[TGF-β]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Cultured skin [[fibroblasts]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Multiple [[vascular]] segments with [[aneurysms]] and [[dissections]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Dissection]] of the [[Circumflex branch of left coronary artery|posterolateral branch of the left circumflex coronary artery (LCx)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Visceral]] [[arteries]] abnormality
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vascular anomaly|Vascular abnormalities]] in [[MRA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Thin and rare [[collagen]] bundles in the [[dermis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |History and [[physical examination]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bleeding]], [[Easy bruising|Bruisability]], [[Heart murmur]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Polymyalgia rheumatica|Polymyalgia rheumatica (PMR)]]<ref name="pmid18390527">{{cite journal| author=Michet CJ, Matteson EL| title=Polymyalgia rheumatica. | journal=BMJ | year= 2008 | volume= 336 | issue= 7647 | pages= 765-9 | pmid=18390527 | doi=10.1136/bmj.39514.653588.80 | pmc=2287267 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18390527  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fibrinogen|Plasma fibrinogen]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Normocytic normochromic anemia|Normocytic, normochromic anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CRP]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Odontoid process|Periodontoid]] localization of [[calcification]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vessel wall]] thickening, Increased mural contrast enhancement
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Subacromial bursitis|Subacromial]] or subdeltoid [[bursitis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |High [[Fluorescein sodium|F-FDG]] accumulation around the [[joints]] in [[Positron emission tomography|FDG PET-CT]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Small angular fibers, [[Pyknosis|Pyknotic]] [[nuclear]] clumps, or target-targetoid fibers
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Joint stiffness]], [[Fatigue]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Amyloidosis]]<ref name="pmid23227278">{{cite journal| author=Baker KR, Rice L| title=The amyloidoses: clinical features, diagnosis and treatment. | journal=Methodist Debakey Cardiovasc J | year= 2012 | volume= 8 | issue= 3 | pages= 3-7 | pmid=23227278 | doi= | pmc=3487569 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23227278  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Immunoglobulin light chains|Immunoglobulin light chain]][[Amyloid beta|(Amyloid)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑ [[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]],
-↑ [[ALT]] or [[AST]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Diffusely hypoattenuating and enlarged [[liver]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Amyloid]] deposition in the media and [[adventitia]] of small arteries
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Solid organs increased [[echogenicity]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Tc-DPD for [[cardiac]] '''[[amyloid]]''' deposits
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Extracellular]] deposition of [[Fibrillarin|fibrillar proteins]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Biopsy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cardiomegaly]], [[Dyspnea]]
-|-
-! colspan="3" style="background:#4479BA; color: #FFFFFF;" align="center" |Diseases
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Headache
-! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |Fever
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Weight loss
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Arthralgia
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Claudication
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Bruit
-! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |HTN
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Focal neurological disorder
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Biomarker
-! style="background:#4479BA; color: #FFFFFF;" align="center" |CBC
-! style="background:#4479BA; color: #FFFFFF;" align="center" |ESR
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
-! style="background:#4479BA; color: #FFFFFF;" align="center" |CT scan
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Angiography
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Ultrasound/ Echocardiography
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Histopathology
-! style="background:#4479BA; color: #FFFFFF;" align="center" |'''Gold standard'''
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Additional findings
 |-
 ! rowspan="18" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Medium-Vessel Vasculitis
@@ Line 649: / Line 437: @@
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Conventional [[radiography]]
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Rash|Evanescent rash]], [[Dactylitis]]
-|-
-! colspan="3" style="background:#4479BA; color: #FFFFFF;" align="center" |Diseases
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Headache
-! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |Fever
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Weight loss
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Arthralgia
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Claudication
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Bruit
-! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |HTN
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Focal neurological disorder
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Biomarker
-! style="background:#4479BA; color: #FFFFFF;" align="center" |CBC
-! style="background:#4479BA; color: #FFFFFF;" align="center" |ESR
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
-! style="background:#4479BA; color: #FFFFFF;" align="center" |CT scan
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Angiography
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Ultrasound/ Echocardiography
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Histopathology
-! style="background:#4479BA; color: #FFFFFF;" align="center" |'''Gold standard'''
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Additional findings
-|-
-! rowspan="30" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Small-Vessel Vasculitis
-! rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[ANCA-associated vasculitis]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Microscopic polyangiitis]]<ref name="pmid20688249">{{cite journal| author=Chung SA, Seo P| title=Microscopic polyangiitis. | journal=Rheum Dis Clin North Am | year= 2010 | volume= 36 | issue= 3 | pages= 545-58 | pmid=20688249 | doi=10.1016/j.rdc.2010.04.003 | pmc=2917831 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20688249  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C-ANCA|Anti-PR3 antibody (C-ANCA)]] (40%), [[P-ANCA|Anti-MPO antibody (P-ANCA)]] (60%)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Normocytic anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Proteinuria]], [[RBC casts|Erythrocyte casts]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Suspected [[pancreatitis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Mesenteric]] [[angiography]] for differentiating from [[polyarteritis nodosa]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Bilateral nodular, and patchy [[Opacity|opacities]] in [[Chest X-ray|CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Glomerulonephritis]] with focal [[necrosis]], crescent formation, and lack or paucity of [[immunoglobulin]] deposits
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Rash]], [[Hemoptysis]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Granulomatosis with polyangiitis|Granulomatosis with polyangiitis (Wegener’s)]]<ref name="pmid27195187">{{cite journal| author=Kubaisi B, Abu Samra K, Foster CS| title=Granulomatosis with polyangiitis (Wegener's disease): An updated review of ocular disease manifestations. | journal=Intractable Rare Dis Res | year= 2016 | volume= 5 | issue= 2 | pages= 61-9 | pmid=27195187 | doi=10.5582/irdr.2016.01014 | pmc=4869584 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27195187  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C-ANCA|Anti-PR3 antibody (C-ANCA)]] (90%), [[P-ANCA|Anti-MPO antibody (P-ANCA)]] (10%)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Normochromic anemia|Normochromic normocytic anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]], [[Hypoalbuminemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Consolidation (medicine)|Consolidation]], Patchy or diffuse [[Ground glass opacification on CT|ground-glass opacities]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Occlusion]] or [[stenosis]] of [[LAD]] and [[RCA]] in [[coronary angiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Single or multiple [[nodules]] and [[Mass|masses]] with [[cavitation]] in [[CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Parenchymal]] [[necrosis]], [[Granulomatous]] [[inflammation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Conjunctivitis]],
-[[Episcleritis]],
-[[Uveitis]],
-[[Optic nerve]] vasculitis
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Eosinophilic granulomatosis with polyangiitis|Eosinophilic granulomatosis with polyangiitis]]
-[[Eosinophilic granulomatosis with polyangiitis|(Churg-Strauss)]]<ref name="pmid16612766">{{cite journal |vauthors=Keogh KA, Specks U |title=Churg-Strauss syndrome |journal=Semin Respir Crit Care Med |volume=27 |issue=2 |pages=148–57 |date=April 2006 |pmid=16612766 |doi=10.1055/s-2006-939518 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[P-ANCA|Anti-MPO antibody (P-ANCA)]] (40%), Eotaxin-3
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Eosinophilia]], [[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]], [[Proteinuria]], [[RBC casts|Erythrocyte casts]], ↑[[Immunoglobulin E|IgE]] levels
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Significant enlargement of peripheral [[pulmonary arteries]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Myocardial ischemia]] and [[Myocardial infarction|infarction]] in [[coronary angiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Congestive heart failure|Congestive heart failure (CHF)]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Extensive air-space [[Opacity|opacities]] in [[CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Small [[necrotizing]] [[granulomas]] with  [[eosinophilic]] core surrounded by [[macrophages]] and [[Epithelioid cell|epithelioid giant cells]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Allergic rhinitis]], [[Asthma]], [[Urticaria|Urticarial rash]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hydralazine]]-associated [[ANCA-associated vasculitis]]<ref name="pmid23316942">{{cite journal| author=Keasberry J, Frazier J, Isbel NM, Van Eps CL, Oliver K, Mudge DW| title=Hydralazine-induced anti-neutrophil cytoplasmic antibody-positive renal vasculitis presenting with a vasculitic syndrome, acute nephritis and a puzzling skin rash: a case report. | journal=J Med Case Rep | year= 2013 | volume= 7 | issue=  | pages= 20 | pmid=23316942 | doi=10.1186/1752-1947-7-20 | pmc=3565908 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23316942  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[P-ANCA|Anti-MPO antibody (P-ANCA)]], Anti-histone antibodies
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]], [[Hypoalbuminemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Bilateral [[pulmonary]] infiltrates
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms]] or [[Occlusion|occlusions]] of the [[Visceral|visceral arteries]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Pauci-immune [[necrotizing]] and [[crescentic glomerulonephritis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Sinusitis]], [[Hemoptysis]]
-|-
-! rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Immune complexes|Immune complex]] small-vessel vasculitis
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Goodpasture disease|Anti-glomerular basement membrane disease]]<ref name="pmid28515156">{{cite journal |vauthors=McAdoo SP, Pusey CD |title=Anti-Glomerular Basement Membrane Disease |journal=Clin J Am Soc Nephrol |volume=12 |issue=7 |pages=1162–1172 |date=July 2017 |pmid=28515156 |doi=10.2215/CJN.01380217 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-GBM antibody|Anti-GBM antibodies]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypochromic anemia|Hypochromic microcytic anemia]], [[Thrombocytopenia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↓[[C3 (complement)|C3]] level
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary hemorrhage]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal [[kidneys]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Alveolar]] infiltrates spreading from the [[hilum]] in [[CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Cellular crescents in the [[glomeruli]], [[Pulmonary hemorrhage|Intra-alveolar hemorrhages]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-GBM antibody|Anti-GBM antibodies]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hemoptysis]], [[Hematuria]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cryoglobulinemia|Cryoglobulinemic vasculitis]]<ref name="pmid16344620">{{cite journal |vauthors=Ferri C, Mascia MT |title=Cryoglobulinemic vasculitis |journal=Curr Opin Rheumatol |volume=18 |issue=1 |pages=54–63 |date=January 2006 |pmid=16344620 |doi= |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C4A|C4 component]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antinuclear antibodies|ANA]], [[hypocomplementemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |R/O underlying [[malignancy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Stenosis]] or [[Occlusion|occlusions]] of the [[Visceral|visceral arteries]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bacterial endocarditis]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Interstitial]] involvement or [[pleural effusions]] in [[CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[HCV]]-associated [[proteins]] in [[vasculitic]] [[skin]], Intraluminal [[cryoglobulin]] deposits
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Acrocyanosis]], [[Retinal]] [[hemorrhage]], [[Purpura]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hepatitis C virus]]-associated [[Cryoglobulinemia|cryoglobulinemic vasculitis]]<ref name="pmid28810602">{{cite journal| author=Guo QY, Wu M, Wang YW, Sun GD| title=Hepatitis C virus-associated cryoglobulinemia with membrano-proliferative glomerulonephritis treated with prednisolone and interferon: A case report. | journal=Exp Ther Med | year= 2017 | volume= 14 | issue= 2 | pages= 1395-1398 | pmid=28810602 | doi=10.3892/etm.2017.4671 | pmc=5525644 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28810602  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatitis C|HCV RNA]], [[Cryoglobulins]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↓[[C4A|Serum C4]], Positive [[RF]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased [[hepatic]] [[echogenicity]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatomegaly]], [[Splenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased [[hepatic]] [[echogenicity]] in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vasculitic]] skin, [[Antigen]] infilteration in [[lesions]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatitis C|HCV RNA]], [[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Palpable [[purpura]], [[Microscopic hematuria]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Henoch-Schönlein purpura|IgA vasculitis (Henoch-Schönlein purpura)]]<ref name="pmid26990342">{{cite journal |vauthors=Farhadian JA, Castilla C, Shvartsbeyn M, Meehan SA, Neimann A, Pomeranz MK |title=IgA vasculitis (Henoch-Schönlein purpura) |journal=Dermatol. Online J. |volume=21 |issue=12 |pages= |date=December 2015 |pmid=26990342 |doi= |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[IgA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Normochromic anemia]], [[Leukocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Occult blood|Stool OB]], ↓[[C3 (complement)|C3]], ↓[[C4A|C4]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased [[bowel]] wall thickness, [[Hematoma|hematomas]], [[peritoneal fluid]], and [[intussusception]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Dilated loops of [[bowel]] consistent in [[abdominal X-ray]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytoclastic vasculitis]] in postcapillary [[venules]] with [[IgA]] deposition
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |History and [[physical examination]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]], [[Purpura|Palpable purpura]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hypocomplementemia|Hypocomplementemic urticarial vasculitis (anti-C1q vasculitis)]]<ref name="pmid22328958">{{cite journal| author=Buck A, Christensen J, McCarty M| title=Hypocomplementemic urticarial vasculitis syndrome: a case report and literature review. | journal=J Clin Aesthet Dermatol | year= 2012 | volume= 5 | issue= 1 | pages= 36-46 | pmid=22328958 | doi= | pmc=3277093 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22328958  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C11orf1|C1q]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antinuclear antibodies|ANA]], ↓[[C10orf10|C1q]], ↓[[C3 (complement)|C3]], ↓[[C4A|C4]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatomegaly]], [[Splenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Deposits of [[immunoglobulins]], [[complement]], or [[fibrin]] around [[blood vessels]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Urticaria]],
-[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Urticaria]], [[Hematuria]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Gastrointestinal diseases|Gastrointestinal disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Acute mesenteric ischemia]]<ref name="pmid24267504">{{cite journal |vauthors=Sise MJ |title=Acute mesenteric ischemia |journal=Surg. Clin. North Am. |volume=94 |issue=1 |pages=165–81 |date=February 2014 |pmid=24267504 |doi=10.1016/j.suc.2013.10.012 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[FABP1|I-FABP]], [[GSTA1|Alpha-GST]], [[Ischemia-modified albumin (IMA)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], ↑[[Hematocrit|HCT]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" | ↑[[Amylase]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bowel]] wall thickening, [[Pneumatosis intestinalis|Intestinal pneumatosis]], [[Mesenteric ischemia|Portomesenteric]] thrombosis
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Mesenteric vein thrombosis|Mesenteric venous thrombosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Artery|Arterial]] [[stenosis]] or occlusion of the [[Celiac artery|celiac]] or [[superior mesenteric arteries]] in [[duplex ultrasound]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Ileus]] with distended loops of [[bowel]], [[Bowel]] wall thickening in [[abdominal X-ray]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Superficial [[Mucosal bleeding|mucosal hemorrhage]], [[edema]] and [[necrosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |History and [[physical examination]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Abdominal pain]], [[Distension]], [[Absent bowel sounds]]
-|-
-! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cardiovascular diseases|Cardiovascular disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Infective Endocarditis]]<ref name="pmid19665088">{{cite journal| author=McDonald JR| title=Acute infective endocarditis. | journal=Infect Dis Clin North Am | year= 2009 | volume= 23 | issue= 3 | pages= 643-64 | pmid=19665088 | doi=10.1016/j.idc.2009.04.013 | pmc=2726828 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19665088  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[NT-proBNP]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Normochromic anemia|Normochromic-normocytic anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypergammaglobulinemia|Hyperglobulinemia]], [[Cryoglobulinemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Metastatic]] [[infections]], such as [[Splenic infarction|splenic infarct]], [[Renal infarct|renal infarcts]], or [[psoas abscess]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vegetation (pathology)|Vegetation]], [[abscess]], or new dehiscence of a [[Prosthetic valves|prosthetic valve]]<nowiki/>in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vertebral osteomyelitis]] in [[Magnetic resonance imaging|MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vegetation (pathology)|Vegetation]] or [[Abscess|intracardiac abscess]] demonstrating active [[endocarditis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Echocardiography]] ([[TTE]])
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Janeway lesions]], [[Osler nodes]], [[Roth's spot|Roth spots]], [[Vertebral osteomyelitis]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Leukocytoclastic vasculitis|Leukocytoclastic Vasculitis]]<ref name="pmid26176572">{{cite journal| author=Einhorn J, Levis JT| title=Dermatologic Diagnosis: Leukocytoclastic Vasculitis. | journal=Perm J | year= 2015 | volume= 19 | issue= 3 | pages= 77-8 | pmid=26176572 | doi=10.7812/TPP/15-001 | pmc=4500485 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26176572  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[IgM]], [[IgA]], [[Immunoglobulin G|IgG]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypocomplementemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vascular]] [[stenosis]] and [[obstruction]] in visceral [[Angiogram|angiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Perivascular [[inflammatory]] infiltrate of [[neutrophils]] with leukocytoclasia (releasing [[nuclear]] debris)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Purpura|Palpable purpura]], [[Petechiae]]
-|-
-! rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Pulmonary disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Langerhans Cell Histiocytosis]]<ref name="pmid18572052">{{cite journal |vauthors=Margo CE, Goldman DR |title=Langerhans cell histiocytosis |journal=Surv Ophthalmol |volume=53 |issue=4 |pages=332–58 |date=2008 |pmid=18572052 |doi=10.1016/j.survophthal.2008.04.007 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CD1a]], CD207,[[BRAF (gene)|BRAF-V600E]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypercalcemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary cystic lymphangiectasis|Pulmonary cysts]] and [[Pulmonary nodule|nodules]], [[Lytic|Bone lytic lesions]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatomegaly]], [[Splenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cerebellum]] and [[pons]] hyperintensity in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Birbeck granules]] by [[electron microscopy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Brown to purplish [[papules]], [[Eczematous Scaling|Eczematous rash]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Non small cell lung cancer|Non-Small Cell Lung Cancer]]<ref name="pmid18452692">{{cite journal| author=Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA| title=Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. | journal=Mayo Clin Proc | year= 2008 | volume= 83 | issue= 5 | pages= 584-94 | pmid=18452692 | doi=10.4065/83.5.584 | pmc=2718421 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18452692  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[EGFR]], ''[[ROS1]],'' [[Anaplastic lymphoma kinase|EML4-''ALK'']],  [[PD-L1]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypercalcemia]], [[Hyponatremia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary|Pulmonary lesion]] or [[mass]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary]] marginal [[lesions]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cancer staging|Staging]] and response to treatment in [[Positron emission tomography|PET-CT]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Adenocarcinoma of the lung pathophysiology|Adenocarcinoma]], [[Squamous cell carcinoma of the lung pathophysiology|Squamous cell carcinoma]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Computed tomography|High resolution CT-scan]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cough]], [[Hemoptysis]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Small cell lung cancer|Small Cell Lung Cancer]]<ref name="pmid16226617">{{cite journal |vauthors=Jackman DM, Johnson BE |title=Small-cell lung cancer |journal=Lancet |volume=366 |issue=9494 |pages=1385–96 |date=2005 |pmid=16226617 |doi=10.1016/S0140-6736(05)67569-1 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |''[[P53 (protein)|p53]],'' [[Thyroid transcription factor-1|Thyroid transcription factor-1 (TTF1)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hyponatremia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Large [[hilar]] mass with bulky [[mediastinal]] [[adenopathy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Endobronchial [[ultrasound]] (EBUS)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Standard [[Staging (pathology)|staging]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Spindled cells with dark [[nuclei]], scant [[cytoplasm]], and fine, granular [[Chromatin|nuclear chromatin]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Computed tomography|High resolution CT-scan]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cough]], [[Hemoptysis]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Pulmonary Infarction]]<ref name="pmid15821192">{{cite journal |vauthors=Parambil JG, Savci CD, Tazelaar HD, Ryu JH |title=Causes and presenting features of pulmonary infarctions in 43 cases identified by surgical lung biopsy |journal=Chest |volume=127 |issue=4 |pages=1178–83 |date=April 2005 |pmid=15821192 |doi=10.1378/chest.127.4.1178 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[D-dimer]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[leukocytosis]], Mild [[anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypoxemia]], [[Hypocarbia]] or [[Hypercarbia]],  [[Respiratory alkalosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary embolism]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Low-[[density]] filling defect within the [[pulmonary artery]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pericardial effusion]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary]] infiltrates, [[atelectasis]], and [[pleural effusions]] in [[Chest X-ray|CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Infarct]] induced [[apoptosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary artery]] [[angiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cough]], [[Hemoptysis]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Renal disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Acute poststreptococcal glomerulonephritis|Acute Poststreptococcal Glomerulonephritis]]<ref name="pmid25554106">{{cite journal |vauthors=VanDeVoorde RG |title=Acute poststreptococcal glomerulonephritis: the most common acute glomerulonephritis |journal=Pediatr Rev |volume=36 |issue=1 |pages=3–12; quiz 13 |date=January 2015 |pmid=25554106 |doi=10.1542/pir.36-1-3 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antistreptococcal antibodies|Antistreptolysin-O (ASO) titers]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypocomplementemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal to slightly enlarged [[kidneys]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Central venous pressure|Central venous]] congestion in a [[hilar]] pattern  in [[Chest X-ray|CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Hypercellularity of [[Endothelial cells|endothelial]] and [[mesangial cells]], Infiltration of the [[glomerular]] tuft with [[polymorphonuclear cells]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]]
-|-
-! rowspan="8" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hematologic disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hemolytic-uremic syndrome|Hemolytic-Uremic Syndrome]]<ref name="pmid11691946">{{cite journal |vauthors=Corrigan JJ, Boineau FG |title=Hemolytic-uremic syndrome |journal=Pediatr Rev |volume=22 |issue=11 |pages=365–9 |date=November 2001 |pmid=11691946 |doi= |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C5a|C5b-9]], [[ADAMTS13]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]], [[Thrombocytopenia]], [[Reticulocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Lactate dehydrogenase|Lactate dehydrogenase (LDH)]], [[Hypercalcemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thalami]], [[brainstem]], or [[cerebellum]] abnormality
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cerebral]] [[microangiopathy]] or [[hypertension]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Hypoechoic [[kidney]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Abnormal hyperintensity in the [[Brain|brain cisterns]] in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thromboses|Microthromboses]] include [[Fibrin|fibrin thrombi]] that may occlude the [[glomerular]] tuft
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[Medical laboratory|laboratory abnormalities]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]], [[Proteinuria]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Chronic Lymphocytic Leukemia|Chronic Lymphocytic Leukemia (CLL)]]<ref name="pmid15561682">{{cite journal |vauthors=Byrd JC, Stilgenbauer S, Flinn IW |title=Chronic lymphocytic leukemia |journal=Hematology Am Soc Hematol Educ Program |volume= |issue= |pages=163–83 |date=2004 |pmid=15561682 |doi=10.1182/asheducation-2004.1.163 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CD5]], [[CD19]], [[CD20]], IgV<sub>H</sub>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Absolute [[lymphocytosis]], Smudge cells
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Flow cytometry]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cancer staging|Staging]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Large atypical [[Cells (biology)|cells]], cleaved cells, and [[prolymphocytes]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Chromosomal]] and [[genetic testing]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Easy bruising]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Multiple myeloma|Multiple Myeloma]]<ref name="pmid28318212">{{cite journal |vauthors=Michels TC, Petersen KE |title=Multiple Myeloma: Diagnosis and Treatment |journal=Am Fam Physician |volume=95 |issue=6 |pages=373–383 |date=March 2017 |pmid=28318212 |doi= |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Light chain|Ig light chain]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]], [[Thrombocytopenia]], [[Leukopenia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bone marrow aspiration]] and [[biopsy]], ↑[[Cr]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Osseous]] involvement and [[Lytic|lytic lesions]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Peripheral zone of increased [[vascularity]] in lesions
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Punched-out lesion in [[X-ray|skull X-ray]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clonal proliferation of [[plasma cells]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Protein electrophoresis]] plus conventional [[X-rays]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Constipation]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hypereosinophilic syndrome|Hypereosinophilic Syndrome]]<ref name="pmid19630574">{{cite journal |vauthors=Klion A |title=Hypereosinophilic syndrome: current approach to diagnosis and treatment |journal=Annu. Rev. Med. |volume=60 |issue= |pages=293–306 |date=2009 |pmid=19630574 |doi=10.1146/annurev.med.60.062107.090340 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[IgE]], [[CD117]] with [[CD2]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Eosinophilia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑Serum [[tryptase]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lymphadenopathy]] and [[splenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Intracardiac thrombus|Intracardiac thrombi]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Reticulin|Reticulin stain]] for [[myelofibrosis]] and [[tryptase]] staining for [[mast cells]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[Medical laboratory|laboratory abnormalities]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Splinter hemorrhages]], [[Raynaud phenomenon]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Non-Hodgkin lymphoma|Non-Hodgkin Lymphoma]]<ref name="pmid22835603">{{cite journal |vauthors=Shankland KR, Armitage JO, Hancock BW |title=Non-Hodgkin lymphoma |journal=Lancet |volume=380 |issue=9844 |pages=848–57 |date=September 2012 |pmid=22835603 |doi=10.1016/S0140-6736(12)60605-9 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C-myc|MYC]], [[BCL2-like 1 (gene)|BCL2]], [[BCL6]], and [[TP53]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lymphocytosis]], [[Anemia]], [[Thrombocytopenia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Lactate dehydrogenase|Lactate dehydrogenase (LDH)]], [[Hypercalcemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Enlarged [[Lymph node|lymph nodes]], [[Hepatosplenomegaly]], Filling defects in the [[liver]] and [[spleen]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatosplenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Mediastinal lymphadenopathy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Small cleaved or noncleaved, intermediate, or large cell with a follicular or diffuse pattern
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Surgically excised tissue [[biopsy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Easy bruising]], [[Testicular mass]], [[Skin lesions|Skin lesion]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Serum sickness|Serum Sickness]]<ref name="pmid2867672">{{cite journal |vauthors=Lin RY |title=Serum sickness syndrome |journal=Am Fam Physician |volume=33 |issue=1 |pages=157–62 |date=January 1986 |pmid=2867672 |doi= |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[IL-1]], [[IL-6]], [[TNF]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukopenia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Gammopathy|Polyclonal gammopathy]], ↑[[Cr]], [[Cryoglobulinemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Arteritic lesions are focal, [[necrotizing]], and [[inflammatory]]  involving all layers of the [[artery]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[Medical laboratory|laboratory abnormalities]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]], [[Skin rash]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Disseminated intravascular coagulation|Disseminated Intravascular Coagulation]]<ref name="pmid25535423">{{cite journal| author=Venugopal A| title=Disseminated intravascular coagulation. | journal=Indian J Anaesth | year= 2014 | volume= 58 | issue= 5 | pages= 603-8 | pmid=25535423 | doi=10.4103/0019-5049.144666 | pmc=4260307 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25535423  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fibrin degradation product|Fibrin degradation product (FDP)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thrombocytopenia]], [[Schistocytes]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[D-dimer]], [[aPTT]] and [[PT]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Intracranial hemorrhage]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Ischemia]] and [[necrosis]] due to [[Fibrin|fibrin deposition]] in small and medium-sized [[vessels]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[Medical laboratory|laboratory abnormalities]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" | [[Cyanosis|Acral cyanosis]], [[Hemorrhagic]] skin [[Infarction|infarctions]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Idiopathic thrombocytopenic purpura|Idiopathic Thrombocytopenic Purpura]]<ref name="pmid27441004">{{cite journal| author=Nomura S| title=Advances in Diagnosis and Treatments for Immune Thrombocytopenia. | journal=Clin Med Insights Blood Disord | year= 2016 | volume= 9 | issue=  | pages= 15-22 | pmid=27441004 | doi=10.4137/CMBD.S39643 | pmc=4948655 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27441004  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[FCGR2B|FC gamma receptors (FCGR) IIb]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]], [[Thrombocytopenia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[HIV]], [[ANA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |R/O other causes
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |R/O [[splenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased number of normal morphologic [[megakaryocytes]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[thrombocytopenia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Easy bruising]], [[Purpura]]
-|-
-! rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Sarcoidosis]]<ref name="pmid27454074">{{cite journal| author=Chiarchiaro J, Chen BB, Gibson KF| title=New molecular targets for the treatment of sarcoidosis. | journal=Curr Opin Pulm Med | year= 2016 | volume= 22 | issue= 5 | pages= 515-21 | pmid=27454074 | doi=10.1097/MCP.0000000000000304 | pmc=5152532 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27454074  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" | [[IL-2]] and [[Interferon gamma|IFN-γ]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Angiotensin-converting enzyme|ACE]], ↑[[Vitamin D|1, 25-dihydroxyvitamin D]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Active [[alveolitis]] or [[fibrosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatosplenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Bilateral [[Adenopathy|hilar adenopathy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Granuloma|Noncaseating granulomas (NCGs)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Heart block]], [[Ocular disease|Ocular lesion]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Legionella Infections|Legionella Infection]]<ref name="pmid12491204">{{cite journal |vauthors=Murdoch DR |title=Diagnosis of Legionella infection |journal=Clin. Infect. Dis. |volume=36 |issue=1 |pages=64–9 |date=January 2003 |pmid=12491204 |doi=10.1086/345529 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cytokine|Inflammatory cytokines]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]] with [[left shift]], [[Thrombocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[D-dimer]], [[Fibrin degradation product|FDP]], [[Hyponatremia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pleural effusion]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Nonspecific and indistinguishable [[CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Intra-[[alveolar]] [[inflammation]], [[Abscesses|Microabscesses]] in the [[parenchyma]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Sputum culture]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cough]], [[Diarrhea]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic lupus erythematosus]]<ref name="Tsokos2011">{{cite journal|last1=Tsokos|first1=George C.|title=Systemic Lupus Erythematosus|journal=New England Journal of Medicine|volume=365|issue=22|year=2011|pages=2110–2121|issn=0028-4793|doi=10.1056/NEJMra1100359}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-dsDNA antibody|Anti dsDNA]], [[ANA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" | [[Leukopenia]], [[Lymphopenia]], [[Anemia]],  [[Thrombocytopenia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]],
-↑[[ALT]] or [[AST]], [[Proteinuria]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Interstitial lung disease, [[Pneumonitis]], [[Pulmonary emboli]], [[Hemorrhage|Alveolar hemorrhage]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pericardial effusion]], [[pulmonary hypertension]], or verrucous [[Libman-Sacks endocarditis]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Central nervous system|Central nervous system (CNS)]] [[Systemic lupus erythematosus|lupus]] white-matter changes in [[MRI]]
-! align="center"  style="padding: 5px 5px; background: #F5F5F5;" |Staging [[lupus nephritis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-dsDNA antibody|Anti-dsDNA antibody test]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Skin rashes]] or [[photosensitivity]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Rheumatoid arthritis]]<ref name="pmid16824912">{{cite journal| author=Scott JT| title=The gold standard in rheumatoid arthritis. | journal=J R Soc Med | year= 1991 | volume= 84 | issue= 9 | pages= 513-4 | pmid=1682491 | doi= | pmc=1293405 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1682491  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[RF]], [[Anti-citrullinated protein antibody|Anti-CCP antibody]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]],
-↑[[ALT]] or [[AST]], [[ANA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fractures|Microfractures]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Joint (anatomy)|Effusions in joints]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Basilar invagination with [[cranial]] migration of an eroded [[Odontoid process|odontoid]] peg in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Influx of [[inflammatory cells]] into the [[synovial membrane]], with  [[angiogenesis]], proliferation of chronic [[inflammatory cells]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled [[Anti-citrullinated protein antibody|anti-CCP antibody]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Rheumatoid nodules]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Relapsing polychondritis]]<ref name="pmid27708954">{{cite journal| author=Emmungil H, Aydın SZ| title=Relapsing polychondritis. | journal=Eur J Rheumatol | year= 2015 | volume= 2 | issue= 4 | pages= 155-159 | pmid=27708954 | doi=10.5152/eurjrheum.2015.0036 | pmc=5047229 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27708954  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cryoglobulins]], [[ANA]], [[C-ANCA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Calcification]] of [[Cartilaginous|cartilaginous structures]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aortic root|Aortic root dilatation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aortic root|Aortic root dilatation]] and degree of [[aortic regurgitation]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Tracheal stenosis]] in [[CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Chondrolysis, [[Chondritis]],  Perichondritis
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with imaging
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Ear pain]] and redness, [[Polyarthritis]]
-|-
-! colspan="3" style="background:#4479BA; color: #FFFFFF;" align="center" |Diseases
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Headache
-! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |Fever
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Weight loss
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Arthralgia
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Claudication
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Bruit
-! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |HTN
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Focal neurological disorder
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Biomarker
-! style="background:#4479BA; color: #FFFFFF;" align="center" |CBC
-! style="background:#4479BA; color: #FFFFFF;" align="center" |ESR
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
-! style="background:#4479BA; color: #FFFFFF;" align="center" |CT scan
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Angiography
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Ultrasound/ Echocardiography
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Histopathology
-! style="background:#4479BA; color: #FFFFFF;" align="center" |'''Gold standard'''
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Additional findings
-|-
-! rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Variable-vessel vasculitis
-! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Behçet's disease|Behçet’s syndrome]]<ref name="pmid17334337">{{cite journal |vauthors=Yazici H, Fresko I, Yurdakul S |title=Behçet's syndrome: disease manifestations, management, and advances in treatment |journal=Nat Clin Pract Rheumatol |volume=3 |issue=3 |pages=148–55 |date=March 2007 |pmid=17334337 |doi=10.1038/ncprheum0436 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CXCL1]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[anemia]], [[Neutrophilia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Factor V Leiden]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Focal [[CNS]] lesions
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysm]] formation and [[thrombosis]] areas
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Valve [[Vegetation (pathology)|vegetations]] and [[Thrombi|ventricular thrombi]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Meningoencephalitis]]   in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lymphocytic]] and [[plasma cell]] invasion in the [[prickle cell]] layer of the [[epidermis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical criteria
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Genital skin lesions|Genital ulcerations]], [[Oral ulcerations|Oral ulceration]]
-|-
-! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cogan syndrome|Cogan's syndrome]]<ref name="pmid27373108">{{cite journal| author=Iliescu DA, Timaru CM, Batras M, De Simone A, Stefan C| title=COGAN'S SYNDROME. | journal=Rom J Ophthalmol | year= 2015 | volume= 59 | issue= 1 | pages= 6-13 | pmid=27373108 | doi= | pmc=5729811 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27373108  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" | [[Hsp70|Anti-Hsp70 antibodies]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]], [[Thrombocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[RF]], [[ANA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Thickening and enhancement of both posterior [[sclera]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" | [[Stenosis]], [[thrombosis]] or more lesions in [[aortic root]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aortic insufficiency]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Early [[interstitial keratitis]] by [[slit lamp]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Muscle]] [[necrosis]] and [[atrophy]] resembling [[myositis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |'''[[Red eye]], [[Hearing loss]], [[Vertigo]]'''
-|-
-! rowspan="3" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Gastrointestinal diseases|Gastrointestinal disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Inflammatory bowel disease|Inflammatory Bowel Disease]]<ref name="pmid26900160">{{cite journal| author=Wehkamp J, Götz M, Herrlinger K, Steurer W, Stange EF| title=Inflammatory Bowel Disease. | journal=Dtsch Arztebl Int | year= 2016 | volume= 113 | issue= 5 | pages= 72-82 | pmid=26900160 | doi=10.3238/arztebl.2016.0072 | pmc=4782273 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26900160  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Anti-[[Saccharomyces cerevisiae|Saccharomyces cerevisiae antibody]] (ASCA), [[P-ANCA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" | [[Iron deficiency anemia|Iron]] or [[vitamin deficiency]], [[Fecal occult blood|Stool OB]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Mesenteric]] fat stranding, bowel wall enhancement, increased [[vascularity]] (comb sign)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fistulas]], [[Abscesses]], [[Stenosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Grossly denuded [[Mucosal|mucosa]] with active [[bleeding]] in [[colonoscopy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Crypt abscess|Crypt abscesses]] and [[Ulceration|mucosal ulceration]], [[Granulomas]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Endoscopy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Gastrointestinal bleeding|GI bleeding]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Whipple's disease]]<ref name="pmid11432814">{{cite journal| author=Dutly F, Altwegg M| title=Whipple's disease and "Tropheryma whippelii". | journal=Clin Microbiol Rev | year= 2001 | volume= 14 | issue= 3 | pages= 561-83 | pmid=11432814 | doi=10.1128/CMR.14.3.561-583.2001 | pmc=88990 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11432814  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CCR4|CCR6]], [[Integrin, beta 6|Gut-homing marker integrin β7-chain]], ''[[Tropheryma whipplei|T whippelii DNA]]''
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[anemia]], [[Neutrophilia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fecal fat|72-hour fecal fat determination]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Nonspecific [[malabsorption]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatosplenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Periodic acid-Schiff]]–positive [[macrophages]] infiltration in [[lamina propria]] of the [[small bowel]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Broad-spectrum [[Polymerase chain reaction|PCR]] amplifications
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cachexia]],
-[[Glossitis]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Sjögren's syndrome]]<ref name="pmid28610655">{{cite journal| author=Stefanski AL, Tomiak C, Pleyer U, Dietrich T, Burmester GR, Dörner T| title=The Diagnosis and Treatment of Sjögren's Syndrome. | journal=Dtsch Arztebl Int | year= 2017 | volume= 114 | issue= 20 | pages= 354-361 | pmid=28610655 | doi=10.3238/arztebl.2017.0354 | pmc=5471601 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28610655  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Anti-Ro and Anti-La, Anti-alpha-fodrin [[antibody]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]],
-[[Leukopenia]],
-[[Eosinophilia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypergammaglobulinemia]], Low [[bicarbonate]] level, [[Hypokalemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Salt and pepper or honeycomb appearance in [[parotid glands]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Multicystic or reticular pattern in [[atrophic]] [[salivary gland]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |R/O [[Obstruction|obstructions]] or [[strictures]] with [[Sialography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Focal aggregates of [[lymphocytes]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Schirmer's test|Schirmer test]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Keratoconjunctivitis]], [[Gingival|Gingival inflammation]]
-|-
-! rowspan="6" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Single-organ vasculitis
-! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Primary [[central nervous system]] [[vasculitis]]<ref name="pmid16575852">{{cite journal |vauthors=Benseler SM, Silverman E, Aviv RI, Schneider R, Armstrong D, Tyrrell PN, deVeber G |title=Primary central nervous system vasculitis in children |journal=Arthritis Rheum. |volume=54 |issue=4 |pages=1291–7 |date=April 2006 |pmid=16575852 |doi=10.1002/art.21766 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Von Willebrand factor (vWF)|von Willebrand factor antigen (vWF)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CSF]] [[pleocytosis]], predominantly [[lymphocytes]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cerebral]] [[Infarction|infarcts]] or [[hemorrhages]] with [[mass effect]], or [[hydrocephalus]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysm]] in [[circle of Willis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Progression of the disease or response to therapy in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Chronic [[granulomatous]] [[inflammation]] and [[giant cells]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Skin rash]], [[Purpura]]
-|-
-! rowspan="3" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Infectious disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Aspergillosis]]<ref name="pmid10194462">{{cite journal| author=Latgé JP| title=Aspergillus fumigatus and aspergillosis. | journal=Clin Microbiol Rev | year= 1999 | volume= 12 | issue= 2 | pages= 310-50 | pmid=10194462 | doi= | pmc=88920 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10194462  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aspergillus]] [[nucleic acid]] in [[blood]], [[Galactomannan]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Eosinophilia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑Serum [[Immunoglobulin E|IgE]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aspergilloma]] mass within a cavity
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Mass effect]] [[stenosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aspergilloma]] mass within the brain in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Septate [[hyphae]], branching at acute angles, and tissue [[necrosis]] with  [[Granuloma|granulomata]] and [[blood vessel]] invasion
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hemoptysis]], [[Aspergilloma]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Histoplasmosis]]<ref name="pmid20445761">{{cite journal| author=Guimarães AJ, Nosanchuk JD, Zancopé-Oliveira RM| title=DIAGNOSIS OF HISTOPLASMOSIS. | journal=Braz J Microbiol | year= 2006 | volume= 37 | issue= 1 | pages= 1-13 | pmid=20445761 | doi=10.1590/S1517-83822006000100001 | pmc=2863343 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20445761  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Alkaline phosphatase|ALP]], ↑[[LDH]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cerebral]] [[histoplasmosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Valvular Diseases|Valvular involvement]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[PFTs|PFT]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Presence of [[yeast]] forms in tissue through [[Hematoxylin and eosin stain|hematoxylin and eosin staining]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Sputum cultures]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pneumonia]], [[Mediastinitis]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Herpes Simplex Encephalitis]]<ref name="pmid9163027">{{cite journal |vauthors=Sköldenberg B |title=Herpes simplex encephalitis |journal=Scand J Infect Dis Suppl |volume=100 |issue= |pages=8–13 |date=1996 |pmid=9163027 |doi= |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Herpes simplex virus|HSV]] [[DNA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[lymphocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CSF]] [[pleocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Low-density lesions in the [[Temporal lobe|temporal]] and/or [[frontal lobe]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hemorrhagic]] lesion in [[white matter]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Multinucleated giant cell|Multinuclear giant cells]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[PCR]] or [[brain biopsy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Seizures]],
-[[Vomiting]]
-|-
-! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic diseases|Systemic disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Eclampsia]]<ref name="pmid21822394">{{cite journal| author=Uzan J, Carbonnel M, Piconne O, Asmar R, Ayoubi JM| title=Pre-eclampsia: pathophysiology, diagnosis, and management. | journal=Vasc Health Risk Manag | year= 2011 | volume= 7 | issue=  | pages= 467-74 | pmid=21822394 | doi=10.2147/VHRM.S20181 | pmc=3148420 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21822394  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vascular endothelial growth factor|VEGF]], [[PlGF]], Soluble [[FLT1|FLT-1]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]], [[Thrombocytopenia]], [[Schistocytes]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Bilirubin]], ↓[[Haptoglobin]], ↑[[Lactate dehydrogenase|LDH]], ↑[[Creatinine|Cr]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Cortical hypodense areas in the [[Occipital lobe|occipital lobes]], Diffuse [[cerebral edema]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fetal growth retardation|Poor fetal growth]], [[Oligohydramnios]], Abnormal [[umbilical artery]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased signal at the [[Gray matter|gray-white matter junction]] in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Urinalysis|24-hour urine study]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Seizure]], [[Edema]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Fibromuscular dysplasia]]<ref name="pmid17555581" />
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Transforming growth factor β|Transforming growth factor β (TGF-β)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑ [[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Alternating [[stenosis]] and [[Dilatation|dilatations]] in [[CT angiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Stenosis]] in the [[renal arteries]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Luminal narrowing alternating with [[dilatation]] (Beads sign)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Focal [[concentric]], long-segment [[tubular]] [[stenosis]] or outpouching in [[MRA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Fibrodysplastic changes, [[Collagen]] deposition
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Digital subtraction angiography|Digital subtraction angiography (DSA)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Spontaneous coronary artery dissection|Spontaneous coronary artery dissection (SCAD)]]
 |-
 |}
-</small></small></small>
+</small>
 ==References==

Differentiating Antiphospholipid syndrome from other diseases: Difference between revisions

Revision as of 15:54, 24 April 2018

Overview

Differentiating Antiphospholipid antibody syndrome from other Diseases

References

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