SGK3: Difference between revisions
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== Function == | == Function == | ||
This gene is a member of the | This gene is a member of the [[serine/threonine protein kinase]] family and encodes a [[phosphoprotein]] with a [[PX domain|PX (phox homology) domain]]. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of [[potassium channel|potassium]] and [[chloride channels]]. Alternate [[Alternative splicing|transcriptional splice variants]], encoding different [[Protein isoform|isoforms]], have been characterized.<ref name="entrez" /> | ||
In melanocytic cells SGK3 gene expression may be regulated by [[Microphthalmia-associated transcription factor|MITF]].<ref name="pmid19067971">{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x }}</ref> | In [[Melanocyte|melanocytic cells]] SGK3 gene expression may be regulated by [[Microphthalmia-associated transcription factor|MITF]].<ref name="pmid19067971">{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x }}</ref> | ||
== Interactions == | == Interactions == | ||
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* {{cite journal | vauthors = Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S | title = Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction | journal = Biochem. Biophys. Res. Commun. | volume = 293 | issue = 4 | pages = 1191–6 | year = 2002 | pmid = 12054501 | doi = 10.1016/S0006-291X(02)00349-2 }} | * {{cite journal | vauthors = Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S | title = Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction | journal = Biochem. Biophys. Res. Commun. | volume = 293 | issue = 4 | pages = 1191–6 | year = 2002 | pmid = 12054501 | doi = 10.1016/S0006-291X(02)00349-2 }} | ||
* {{cite journal | vauthors = Brickley DR, Mikosz CA, Hagan CR, Conzen SD | title = Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1) | journal = J. Biol. Chem. | volume = 277 | issue = 45 | pages = 43064–70 | year = 2003 | pmid = 12218062 | doi = 10.1074/jbc.M207604200 }} | * {{cite journal | vauthors = Brickley DR, Mikosz CA, Hagan CR, Conzen SD | title = Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1) | journal = J. Biol. Chem. | volume = 277 | issue = 45 | pages = 43064–70 | year = 2003 | pmid = 12218062 | doi = 10.1074/jbc.M207604200 }} | ||
* {{cite journal | vauthors = Gamper N, Fillon S, Feng Y, Friedrich B, Lang PA, Henke G, Huber SM, Kobayashi T, Cohen P, Lang F | title = K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK | journal = | * {{cite journal | vauthors = Gamper N, Fillon S, Feng Y, Friedrich B, Lang PA, Henke G, Huber SM, Kobayashi T, Cohen P, Lang F | title = K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK | journal = Pflügers Arch. | volume = 445 | issue = 1 | pages = 60–6 | year = 2003 | pmid = 12397388 | doi = 10.1007/s00424-002-0873-2 }} | ||
* {{cite journal | vauthors = Henke G, Setiawan I, Böhmer C, Lang F | title = Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms | journal = Kidney Blood Press. Res. | volume = 25 | issue = 6 | pages = 370–4 | year = 2003 | pmid = 12590200 | doi = 10.1159/000068699 }} | * {{cite journal | vauthors = Henke G, Setiawan I, Böhmer C, Lang F | title = Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms | journal = Kidney Blood Press. Res. | volume = 25 | issue = 6 | pages = 370–4 | year = 2003 | pmid = 12590200 | doi = 10.1159/000068699 }} | ||
* {{cite journal | vauthors = Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Bröer S, Wang J, Pearce D, Lang F | title = The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC | journal = | * {{cite journal | vauthors = Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Bröer S, Wang J, Pearce D, Lang F | title = The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC | journal = Pflügers Arch. | volume = 445 | issue = 6 | pages = 693–6 | year = 2003 | pmid = 12632189 | doi = 10.1007/s00424-002-0993-8 }} | ||
* {{cite journal | vauthors = Embark HM, Böhmer C, Vallon V, Luft F, Lang F | title = Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms | journal = | * {{cite journal | vauthors = Embark HM, Böhmer C, Vallon V, Luft F, Lang F | title = Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms | journal = Pflügers Arch. | volume = 445 | issue = 5 | pages = 601–6 | year = 2003 | pmid = 12634932 | doi = 10.1007/s00424-002-0982-y }} | ||
* {{cite journal | vauthors = Nilsen T, Slagsvold T, Skjerpen CS, Brech A, Stenmark H, Olsnes S | title = Peroxisomal targeting as a tool for assaying protein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner | journal = J. Biol. Chem. | volume = 279 | issue = 6 | pages = 4794–801 | year = 2004 | pmid = 14604990 | doi = 10.1074/jbc.M309653200 }} | * {{cite journal | vauthors = Nilsen T, Slagsvold T, Skjerpen CS, Brech A, Stenmark H, Olsnes S | title = Peroxisomal targeting as a tool for assaying protein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner | journal = J. Biol. Chem. | volume = 279 | issue = 6 | pages = 4794–801 | year = 2004 | pmid = 14604990 | doi = 10.1074/jbc.M309653200 }} | ||
{{refend}} | {{refend}} | ||
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{{Enzymes}} | {{Enzymes}} | ||
{{Portal bar|Molecular and Cellular Biology|border=no}} | {{Portal bar|Molecular and Cellular Biology|border=no}} | ||
[[Category:EC 2.7.11]] | |||
{{gene-8-stub}} | {{gene-8-stub}} | ||
Revision as of 16:07, 29 June 2018
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Serine/threonine-protein kinase Sgk3 is an enzyme that in humans is encoded by the SGK3 gene.[1][2][3]
Function
This gene is a member of the serine/threonine protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]
In melanocytic cells SGK3 gene expression may be regulated by MITF.[4]
Interactions
SGK3 has been shown to interact with GSK3B.[5]
References
- ↑ Dai F, Yu L, He H, Zhao Y, Yang J, Zhang X, Zhao S (February 2000). "Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1". Genomics. 62 (1): 95–7. doi:10.1006/geno.1999.5969. PMID 10585774.
- ↑ Kobayashi T, Deak M, Morrice N, Cohen P (January 2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase". Biochem J. 344 Pt 1 (Pt 1): 189–97. doi:10.1042/0264-6021:3440189. PMC 1220630. PMID 10548550.
- ↑ 3.0 3.1 "Entrez Gene: SGK3 serum/glucocorticoid regulated kinase family, member 3".
- ↑ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
- ↑ Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S (May 2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction". Biochem. Biophys. Res. Commun. 293 (4): 1191–6. doi:10.1016/S0006-291X(02)00349-2. PMID 12054501.
Further reading
- Lang F, Cohen P (2002). "Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms". Sci. STKE. 2001 (108): RE17. doi:10.1126/stke.2001.108.re17. PMID 11707620.
- Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8): 2527–40. doi:10.1021/cr000110o. PMID 11749387.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Fang X, Yu SX, Lu Y, Bast RC, Woodgett JR, Mills GB (2000). "Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A". Proc. Natl. Acad. Sci. U.S.A. 97 (22): 11960–5. doi:10.1073/pnas.220413597. PMC 17277. PMID 11035810.
- Xu J, Liu D, Gill G, Songyang Z (2001). "Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides". J. Cell Biol. 154 (4): 699–705. doi:10.1083/jcb.200105089. PMC 2196448. PMID 11514587.
- Yun CC, Chen Y, Lang F (2002). "Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2". J. Biol. Chem. 277 (10): 7676–83. doi:10.1074/jbc.M107768200. PMID 11751930.
- Fang X, Yu S, Tanyi JL, Lu Y, Woodgett JR, Mills GB (2002). "Convergence of Multiple Signaling Cascades at Glycogen Synthase Kinase 3: Edg Receptor-Mediated Phosphorylation and Inactivation by Lysophosphatidic Acid through a Protein Kinase C-Dependent Intracellular Pathway". Mol. Cell. Biol. 22 (7): 2099–110. doi:10.1128/MCB.22.7.2099-2110.2002. PMC 133668. PMID 11884598.
- Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S (2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction". Biochem. Biophys. Res. Commun. 293 (4): 1191–6. doi:10.1016/S0006-291X(02)00349-2. PMID 12054501.
- Brickley DR, Mikosz CA, Hagan CR, Conzen SD (2003). "Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1)". J. Biol. Chem. 277 (45): 43064–70. doi:10.1074/jbc.M207604200. PMID 12218062.
- Gamper N, Fillon S, Feng Y, Friedrich B, Lang PA, Henke G, Huber SM, Kobayashi T, Cohen P, Lang F (2003). "K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK". Pflügers Arch. 445 (1): 60–6. doi:10.1007/s00424-002-0873-2. PMID 12397388.
- Henke G, Setiawan I, Böhmer C, Lang F (2003). "Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms". Kidney Blood Press. Res. 25 (6): 370–4. doi:10.1159/000068699. PMID 12590200.
- Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Bröer S, Wang J, Pearce D, Lang F (2003). "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC". Pflügers Arch. 445 (6): 693–6. doi:10.1007/s00424-002-0993-8. PMID 12632189.
- Embark HM, Böhmer C, Vallon V, Luft F, Lang F (2003). "Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms". Pflügers Arch. 445 (5): 601–6. doi:10.1007/s00424-002-0982-y. PMID 12634932.
- Nilsen T, Slagsvold T, Skjerpen CS, Brech A, Stenmark H, Olsnes S (2004). "Peroxisomal targeting as a tool for assaying protein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner". J. Biol. Chem. 279 (6): 4794–801. doi:10.1074/jbc.M309653200. PMID 14604990.
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