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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Serine/threonine-protein kinase Sgk3''' is an [[enzyme]] that in humans is encoded by the ''SGK3'' [[gene]].<ref name="pmid10585774">{{cite journal | vauthors = Dai F, Yu L, He H, Zhao Y, Yang J, Zhang X, Zhao S | title = Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1 | journal = Genomics | volume = 62 | issue = 1 | pages = 95–7 | date = February 2000 | pmid = 10585774 | pmc =  | doi = 10.1006/geno.1999.5969 }}</ref><ref name="pmid10548550">{{cite journal | vauthors = Kobayashi T, Deak M, Morrice N, Cohen P | title = Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase | journal = Biochem J | volume = 344 Pt 1 | issue = Pt 1 | pages = 189–97 | date = January 2000 | pmid = 10548550 | pmc = 1220630 | doi = 10.1042/0264-6021:3440189 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SGK3 serum/glucocorticoid regulated kinase family, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23678| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_SGK3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xte.
| PDB = {{PDB2|1xte}}, {{PDB2|1xtn}}
| Name = Serum/glucocorticoid regulated kinase family, member 3
| HGNCid = 10812
| Symbol = SGK3
| AltSymbols =; SGK2; CISK; DKFZp781N0293; SGKL
| OMIM = 607591
| ECnumber = 
| Homologene = 56582
| MGIid = 2182368
| GeneAtlas_image1 = PBB_GE_SGK3_220038_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0035091 |text = phosphoinositide binding}}
| Component = {{GNF_GO|id=GO:0016023 |text = cytoplasmic membrane-bound vesicle}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007154 |text = cell communication}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23678
    | Hs_Ensembl = ENSG00000104205
    | Hs_RefseqProtein = NP_001028750
    | Hs_RefseqmRNA = NM_001033578
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 67787445
    | Hs_GenLoc_end = 67936800
    | Hs_Uniprot = Q96BR1
    | Mm_EntrezGene = 170755
    | Mm_Ensembl = ENSMUSG00000025915
    | Mm_RefseqmRNA = NM_001037759
    | Mm_RefseqProtein = NP_001032848
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 9783344
    | Mm_GenLoc_end = 9887784
    | Mm_Uniprot = Q3U907
  }}
}}
'''Serum/glucocorticoid regulated kinase family, member 3''', also known as '''SGK3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SGK3 serum/glucocorticoid regulated kinase family, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23678| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: SGK3 serum/glucocorticoid regulated kinase family, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23678| accessdate = }}</ref>
}}


==References==
In melanocytic cells SGK3 gene expression may be regulated by [[Microphthalmia-associated transcription factor|MITF]].<ref name="pmid19067971">{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x }}</ref>
{{reflist|2}}
 
==Further reading==
== Interactions ==
 
SGK3 has been shown to [[Protein-protein interaction|interact]] with [[GSK3B]].<ref name=pmid12054501>{{cite journal | vauthors = Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S | title = Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction | journal = Biochem. Biophys. Res. Commun. | volume = 293 | issue = 4 | pages = 1191–6 | date = May 2002 | pmid = 12054501 | doi = 10.1016/S0006-291X(02)00349-2 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Lang F, Cohen P | title = Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms | journal = Sci. STKE | volume = 2001 | issue = 108 | pages = RE17 | year = 2002 | pmid = 11707620 | doi = 10.1126/stke.2001.108.re17 }}
| citations =
* {{cite journal | vauthors = Ali A, Hoeflich KP, Woodgett JR | title = Glycogen synthase kinase-3: properties, functions, and regulation | journal = Chem. Rev. | volume = 101 | issue = 8 | pages = 2527–40 | year = 2002 | pmid = 11749387 | doi = 10.1021/cr000110o }}
*{{cite journal | author=Lang F, Cohen P |title=Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms. |journal=Sci. STKE |volume=2001 |issue= 108 |pages= RE17 |year= 2002 |pmid= 11707620 |doi= 10.1126/stke.2001.108.re17 }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Ali A, Hoeflich KP, Woodgett JR |title=Glycogen synthase kinase-3: properties, functions, and regulation. |journal=Chem. Rev. |volume=101 |issue= 8 |pages= 2527-40 |year= 2002 |pmid= 11749387 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Fang X, Yu SX, Lu Y, Bast RC, Woodgett JR, Mills GB | title = Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 22 | pages = 11960–5 | year = 2000 | pmid = 11035810 | pmc = 17277 | doi = 10.1073/pnas.220413597 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Xu J, Liu D, Gill G, Songyang Z | title = Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides | journal = J. Cell Biol. | volume = 154 | issue = 4 | pages = 699–705 | year = 2001 | pmid = 11514587 | pmc = 2196448 | doi = 10.1083/jcb.200105089 }}
*{{cite journal  | author=Kobayashi T, Deak M, Morrice N, Cohen P |title=Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. |journal=Biochem. J. |volume=344 Pt 1 |issue=  |pages= 189-97 |year= 2000 |pmid= 10548550 |doi=  }}
* {{cite journal | vauthors = Yun CC, Chen Y, Lang F | title = Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2 | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 7676–83 | year = 2002 | pmid = 11751930 | doi = 10.1074/jbc.M107768200 }}
*{{cite journal  | author=Dai F, Yu L, He H, ''et al.'' |title=Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1. |journal=Genomics |volume=62 |issue= 1 |pages= 95-7 |year= 2000 |pmid= 10585774 |doi= 10.1006/geno.1999.5969 }}
* {{cite journal | vauthors = Fang X, Yu S, Tanyi JL, Lu Y, Woodgett JR, Mills GB | title = Convergence of Multiple Signaling Cascades at Glycogen Synthase Kinase 3: Edg Receptor-Mediated Phosphorylation and Inactivation by Lysophosphatidic Acid through a Protein Kinase C-Dependent Intracellular Pathway | journal = Mol. Cell. Biol. | volume = 22 | issue = 7 | pages = 2099–110 | year = 2002 | pmid = 11884598 | pmc = 133668 | doi = 10.1128/MCB.22.7.2099-2110.2002 }}
*{{cite journal | author=Fang X, Yu SX, Lu Y, ''et al.'' |title=Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 22 |pages= 11960-5 |year= 2000 |pmid= 11035810 |doi= 10.1073/pnas.220413597 }}
* {{cite journal | vauthors = Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S | title = Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction | journal = Biochem. Biophys. Res. Commun. | volume = 293 | issue = 4 | pages = 1191–6 | year = 2002 | pmid = 12054501 | doi = 10.1016/S0006-291X(02)00349-2 }}
*{{cite journal | author=Xu J, Liu D, Gill G, Songyang Z |title=Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides. |journal=J. Cell Biol. |volume=154 |issue= 4 |pages= 699-705 |year= 2001 |pmid= 11514587 |doi= 10.1083/jcb.200105089 }}
* {{cite journal | vauthors = Brickley DR, Mikosz CA, Hagan CR, Conzen SD | title = Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1) | journal = J. Biol. Chem. | volume = 277 | issue = 45 | pages = 43064–70 | year = 2003 | pmid = 12218062 | doi = 10.1074/jbc.M207604200 }}
*{{cite journal | author=Yun CC, Chen Y, Lang F |title=Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 7676-83 |year= 2002 |pmid= 11751930 |doi= 10.1074/jbc.M107768200 }}
* {{cite journal | vauthors = Gamper N, Fillon S, Feng Y, Friedrich B, Lang PA, Henke G, Huber SM, Kobayashi T, Cohen P, Lang F | title = K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK | journal = Pflugers Arch. | volume = 445 | issue = 1 | pages = 60–6 | year = 2003 | pmid = 12397388 | doi = 10.1007/s00424-002-0873-2 }}
*{{cite journal | author=Fang X, Yu S, Tanyi JL, ''et al.'' |title=Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway. |journal=Mol. Cell. Biol. |volume=22 |issue= 7 |pages= 2099-110 |year= 2002 |pmid= 11884598 |doi= }}
* {{cite journal | vauthors = Henke G, Setiawan I, Böhmer C, Lang F | title = Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms | journal = Kidney Blood Press. Res. | volume = 25 | issue = 6 | pages = 370–4 | year = 2003 | pmid = 12590200 | doi = 10.1159/000068699 }}
*{{cite journal | author=Dai F, Yu L, He H, ''et al.'' |title=Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 4 |pages= 1191-6 |year= 2002 |pmid= 12054501 |doi= 10.1016/S0006-291X(02)00349-2 }}
* {{cite journal | vauthors = Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Bröer S, Wang J, Pearce D, Lang F | title = The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC | journal = Pflugers Arch. | volume = 445 | issue = 6 | pages = 693–6 | year = 2003 | pmid = 12632189 | doi = 10.1007/s00424-002-0993-8 }}
*{{cite journal | author=Brickley DR, Mikosz CA, Hagan CR, Conzen SD |title=Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1). |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 43064-70 |year= 2003 |pmid= 12218062 |doi= 10.1074/jbc.M207604200 }}
* {{cite journal | vauthors = Embark HM, Böhmer C, Vallon V, Luft F, Lang F | title = Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms | journal = Pflugers Arch. | volume = 445 | issue = 5 | pages = 601–6 | year = 2003 | pmid = 12634932 | doi = 10.1007/s00424-002-0982-y }}
*{{cite journal | author=Gamper N, Fillon S, Feng Y, ''et al.'' |title=K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. |journal=Pflugers Arch. |volume=445 |issue= 1 |pages= 60-6 |year= 2003 |pmid= 12397388 |doi= 10.1007/s00424-002-0873-2 }}
* {{cite journal | vauthors = Nilsen T, Slagsvold T, Skjerpen CS, Brech A, Stenmark H, Olsnes S | title = Peroxisomal targeting as a tool for assaying protein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner | journal = J. Biol. Chem. | volume = 279 | issue = 6 | pages = 4794–801 | year = 2004 | pmid = 14604990 | doi = 10.1074/jbc.M309653200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Henke G, Setiawan I, Böhmer C, Lang F |title=Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms. |journal=Kidney Blood Press. Res. |volume=25 |issue= 6 |pages= 370-4 |year= 2003 |pmid= 12590200 |doi= 10.1159/000068699 }}
*{{cite journal | author=Friedrich B, Feng Y, Cohen P, ''et al.'' |title=The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC. |journal=Pflugers Arch. |volume=445 |issue= 6 |pages= 693-6 |year= 2003 |pmid= 12632189 |doi= 10.1007/s00424-002-0993-8 }}
*{{cite journal | author=Embark HM, Böhmer C, Vallon V, ''et al.'' |title=Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms. |journal=Pflugers Arch. |volume=445 |issue= 5 |pages= 601-6 |year= 2003 |pmid= 12634932 |doi= 10.1007/s00424-002-0982-y }}
*{{cite journal | author=Nilsen T, Slagsvold T, Skjerpen CS, ''et al.'' |title=Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner. |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4794-801 |year= 2004 |pmid= 14604990 |doi= 10.1074/jbc.M309653200 }}
}}
{{refend}}
{{refend}}


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[[Category:EC 2.7.11]]

Revision as of 06:15, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein kinase Sgk3 is an enzyme that in humans is encoded by the SGK3 gene.[1][2][3]

Function

This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]

In melanocytic cells SGK3 gene expression may be regulated by MITF.[4]

Interactions

SGK3 has been shown to interact with GSK3B.[5]

References

  1. ↑ Dai F, Yu L, He H, Zhao Y, Yang J, Zhang X, Zhao S (February 2000). "Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1". Genomics. 62 (1): 95–7. doi:10.1006/geno.1999.5969. PMID 10585774.
  2. ↑ Kobayashi T, Deak M, Morrice N, Cohen P (January 2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase". Biochem J. 344 Pt 1 (Pt 1): 189–97. doi:10.1042/0264-6021:3440189. PMC 1220630. PMID 10548550.
  3. ↑ 3.0 3.1 "Entrez Gene: SGK3 serum/glucocorticoid regulated kinase family, member 3".
  4. ↑ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
  5. ↑ Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S (May 2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction". Biochem. Biophys. Res. Commun. 293 (4): 1191–6. doi:10.1016/S0006-291X(02)00349-2. PMID 12054501.

Further reading


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