Stomatitis differential diagnosis: Difference between revisions
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Stomatitis must be differentiated from its different kinds and from various other disease that can mimic stomatitis or have accompanying features involving other organs. Stomatitis should be differentiated from other disease as well as from possible underlying conditions causing stomatitis including:<ref name="Gangrenous stomatitis">{{cite book |last1=Mandell |firs1t=Gerald |last2=Gouglas |first2=Gordon |last3=Bennett |first3=John |date= |title=Principles and Practice of Infectious Diseases |location= Harvard Medical School |publisher=WILEY MEDICAL |page=383 |isbn=0-471-87643-7}}</ref><ref name="pmid10597357">{{cite journal| author=Scully C| title=A review of common mucocutaneous disorders affecting the mouth and lips. | journal=Ann Acad Med Singapore | year= 1999 | volume= 28 | issue= 5 | pages= 704-7 | pmid=10597357 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10597357 }} </ref> | Stomatitis must be differentiated from its different kinds and from various other disease that can mimic stomatitis or have accompanying features involving other organs. Stomatitis should be differentiated from other disease as well as from possible underlying conditions causing stomatitis including:<ref name="Gangrenous stomatitis">{{cite book |last1=Mandell |firs1t=Gerald |last2=Gouglas |first2=Gordon |last3=Bennett |first3=John |date= |title=Principles and Practice of Infectious Diseases |location= Harvard Medical School |publisher=WILEY MEDICAL |page=383 |isbn=0-471-87643-7}}</ref><ref name="pmid10597357">{{cite journal| author=Scully C| title=A review of common mucocutaneous disorders affecting the mouth and lips. | journal=Ann Acad Med Singapore | year= 1999 | volume= 28 | issue= 5 | pages= 704-7 | pmid=10597357 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10597357 }} </ref> | ||
*Tumors of the tongue | *Tumors of the tongue | ||
**Squamous cell carcinoma | **Squamous cell carcinoma <ref>{{Cite journal | ||
| author = [[R. Morgan]], [[J. Tsang]], [[N. Harrington]] & [[L. Fook]] | | author = [[R. Morgan]], [[J. Tsang]], [[N. Harrington]] & [[L. Fook]] | ||
| title = Survey of hospital doctors' attitudes and knowledge of oral conditions in older patients | | title = Survey of hospital doctors' attitudes and knowledge of oral conditions in older patients | ||
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| pmid = 11375454 | | pmid = 11375454 | ||
}}</ref> | }}</ref> | ||
**Leukoplakia | **Leukoplakia<ref>{{Cite journal | ||
| author = [[D. Grady]], [[J. Greene]], [[T. E. Daniels]], [[V. L. Ernster]], [[P. B. Robertson]], [[W. Hauck]], [[D. Greenspan]], [[J. Greenspan]] & [[S. Jr Silverman]] | | author = [[D. Grady]], [[J. Greene]], [[T. E. Daniels]], [[V. L. Ernster]], [[P. B. Robertson]], [[W. Hauck]], [[D. Greenspan]], [[J. Greenspan]] & [[S. Jr Silverman]] | ||
| title = Oral mucosal lesions found in smokeless tobacco users | | title = Oral mucosal lesions found in smokeless tobacco users | ||
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| month = July | | month = July | ||
| pmid = 2370378 | | pmid = 2370378 | ||
}}</ref> | }}</ref> | ||
**Melanoma | **Melanoma | ||
Line 58: | Line 44: | ||
}}</ref> | }}</ref> | ||
**Fordyce spots | **Fordyce spots | ||
**Torrus Palatinus | **Torrus Palatinus<ref>{{Cite journal | ||
| author = [[Barry Ladizinski]] & [[Kachiu C. Lee]] | | author = [[Barry Ladizinski]] & [[Kachiu C. Lee]] | ||
| title = A nodular protuberance on the hard palate | | title = A nodular protuberance on the hard palate | ||
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*Autoimmune diseases<ref name="pmid28153136">Magliocca KR, Fitzpatrick SG (2017) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=28153136 Autoimmune Disease Manifestations in the Oral Cavity.] ''Surg Pathol Clin'' 10 (1):57-88. [http://dx.doi.org/10.1016/j.path.2016.11.001 DOI:10.1016/j.path.2016.11.001] PMID: [https://pubmed.gov/28153136 28153136]</ref> | *Autoimmune diseases<ref name="pmid28153136">Magliocca KR, Fitzpatrick SG (2017) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=28153136 Autoimmune Disease Manifestations in the Oral Cavity.] ''Surg Pathol Clin'' 10 (1):57-88. [http://dx.doi.org/10.1016/j.path.2016.11.001 DOI:10.1016/j.path.2016.11.001] PMID: [https://pubmed.gov/28153136 28153136]</ref> | ||
**Behcet's syndrome<ref name="pmid17343257">{{cite journal| author=Dalghous AM, Freysdottir J, Fortune F| title=Expression of cytokines, chemokines, and chemokine receptors in oral ulcers of patients with Behcet's disease (BD) and recurrent aphthous stomatitis is Th1-associated, although Th2-association is also observed in patients with BD. | journal=Scand J Rheumatol | year= 2006 | volume= 35 | issue= 6 | pages= 472-5 | pmid=17343257 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17343257 }} </ref> | **Behcet's syndrome<ref name="pmid17343257">{{cite journal| author=Dalghous AM, Freysdottir J, Fortune F| title=Expression of cytokines, chemokines, and chemokine receptors in oral ulcers of patients with Behcet's disease (BD) and recurrent aphthous stomatitis is Th1-associated, although Th2-association is also observed in patients with BD. | journal=Scand J Rheumatol | year= 2006 | volume= 35 | issue= 6 | pages= 472-5 | pmid=17343257 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17343257 }} </ref> | ||
**[[Behcet's syndrome]] | |||
**[[Crohn's disease]] | **[[Crohn's disease]] | ||
*[[Agranulocytosis]] | *[[Agranulocytosis]] | ||
*Drug induced | *Drug induced | ||
*Burning mouth syndrome | *Burning mouth syndrome | ||
*[[Syphilis]] | *[[Syphilis]] | ||
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|[[Squamous cell carcinoma]] | |[[Squamous cell carcinoma]] | ||
| | | | ||
* | *Non healing ulcer, nodule, indurated plaque or mass | ||
*May involve skin, lips, inside the mouth, throat or esophagus | *May involve skin, lips, inside the mouth, throat or esophagus | ||
| | | | ||
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*Lateral borders of tongue | *Lateral borders of tongue | ||
| | | | ||
*[[Tobacco]] use | *Atypical [[Tobacco]] use | ||
*Chronic irritation | *Chronic irritation | ||
*Immunodeficiency | *Immunodeficiency | ||
Line 143: | Line 128: | ||
*Associated with [[HIV]] | *Associated with [[HIV]] | ||
*Persistant white spots | *Persistant white spots | ||
*Benign but can progress to carcinoma after almost 10 years | |||
*Oral proliferative verrucous leukoplakia is an aggressive sub type with multiple lesions and higher conversion to warts or carcinoma<ref>{{Cite journal | |||
| author = [[Ann M. Gillenwater]], [[Nadarajah Vigneswaran]], [[Hanadi Fatani]], [[Pierre Saintigny]] & [[Adel K. El-Naggar]] | |||
| title = Proliferative verrucous leukoplakia (PVL): a review of an elusive pathologic entity! | |||
| journal = [[Advances in anatomic pathology]] | |||
| volume = 20 | |||
| issue = 6 | |||
| pages = 416–423 | |||
| year = 2013 | |||
| month = November | |||
| doi = 10.1097/PAP.0b013e3182a92df1 | |||
| pmid = 24113312 | |||
}}</ref> | |||
|[[File:Oral hairy leukoplakia (EBV, in HIV).jpg|Leukoplakia|400x300px]] | |[[File:Oral hairy leukoplakia (EBV, in HIV).jpg|Leukoplakia|400x300px]] | ||
|- | |- | ||
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| | | | ||
*Bony growth on midline of the hard palate | *Bony growth on midline of the hard palate | ||
*Nodular mass covered with normal mucosa | |||
| | | | ||
*Genetic predisposition | *Genetic predisposition |
Revision as of 15:03, 16 March 2017
Stomatitis Microchapters |
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Stomatitis differential diagnosis On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mehrsefat, M.D. [2]
Overview
Stomatitis should be differentiated from various subtypes of stomatitis and from many other disease that can involve the oral cavity such as agranulocystosis, Behcet's disease, immunodeficiency and tutors of the oral cavity like leukoplakia etc.[1][2]
Differential diagnosis
Stomatitis must be differentiated from its different kinds and from various other disease that can mimic stomatitis or have accompanying features involving other organs. Stomatitis should be differentiated from other disease as well as from possible underlying conditions causing stomatitis including:[1][2]
- Tumors of the tongue
- Autoimmune diseases[7]
- Behcet's syndrome[8]
- Behcet's syndrome
- Crohn's disease
- Agranulocytosis
- Drug induced
- Burning mouth syndrome
- Syphilis
- Coxsackie virus accompanies involvement of the hands and the mouth
- HIV
- VZV or Chicken pox
Disease | Presentation | Risk Factors | Diagnosis | Affected Organ Systems | Important features | Picture |
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Diseases predominantly affecting the oral cavity | ||||||
Squamous cell carcinoma |
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Leukoplakia |
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Melanoma |
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Fordyce spots |
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Burning mouth syndrome |
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Torus palatinus |
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Diseases involving oral cavity and other organ systems | ||||||
Behcet's disease |
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Crohn's disease |
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Agranulocytosis |
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Syphilis[11] |
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Coxsackie virus |
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Chicken pox |
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Measles |
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References
- ↑ 1.0 1.1 Mandell; Gouglas, Gordon; Bennett, John. Principles and Practice of Infectious Diseases. Harvard Medical School: WILEY MEDICAL. p. 383. ISBN 0-471-87643-7. Unknown parameter
|firs1t=
ignored (help) - ↑ 2.0 2.1 Scully C (1999). "A review of common mucocutaneous disorders affecting the mouth and lips". Ann Acad Med Singapore. 28 (5): 704–7. PMID 10597357.
- ↑ R. Morgan, J. Tsang, N. Harrington & L. Fook (2001). "Survey of hospital doctors' attitudes and knowledge of oral conditions in older patients". Postgraduate medical journal. 77 (908): 392–394. PMID 11375454. Unknown parameter
|month=
ignored (help) - ↑ D. Grady, J. Greene, T. E. Daniels, V. L. Ernster, P. B. Robertson, W. Hauck, D. Greenspan, J. Greenspan & S. Jr Silverman (1990). "Oral mucosal lesions found in smokeless tobacco users". Journal of the American Dental Association (1939). 121 (1): 117–123. PMID 2370378. Unknown parameter
|month=
ignored (help) - ↑ P. DeMatos, D. S. Tyler & H. F. Seigler (1998). "Malignant melanoma of the mucous membranes: a review of 119 cases". Annals of surgical oncology. 5 (8): 733–742. PMID 9869521. Unknown parameter
|month=
ignored (help) - ↑ Barry Ladizinski & Kachiu C. Lee (2014). "A nodular protuberance on the hard palate". JAMA. 311 (15): 1558–1559. doi:10.1001/jama.2014.271. PMID 24737369. Unknown parameter
|month=
ignored (help) - ↑ Magliocca KR, Fitzpatrick SG (2017) Autoimmune Disease Manifestations in the Oral Cavity. Surg Pathol Clin 10 (1):57-88. DOI:10.1016/j.path.2016.11.001 PMID: 28153136
- ↑ Dalghous AM, Freysdottir J, Fortune F (2006). "Expression of cytokines, chemokines, and chemokine receptors in oral ulcers of patients with Behcet's disease (BD) and recurrent aphthous stomatitis is Th1-associated, although Th2-association is also observed in patients with BD". Scand J Rheumatol. 35 (6): 472–5. PMID 17343257.
- ↑ Ann M. Gillenwater, Nadarajah Vigneswaran, Hanadi Fatani, Pierre Saintigny & Adel K. El-Naggar (2013). "Proliferative verrucous leukoplakia (PVL): a review of an elusive pathologic entity!". Advances in anatomic pathology. 20 (6): 416–423. doi:10.1097/PAP.0b013e3182a92df1. PMID 24113312. Unknown parameter
|month=
ignored (help) - ↑ Andrès E, Zimmer J, Affenberger S, Federici L, Alt M, Maloisel F. (2006). "Idiosyncratic drug-induced agranulocytosis: Update of an old disorder". Eur J Intern Med. 17 (8): 529–35. Text "pmid 17142169" ignored (help)
- ↑ title="By Internet Archive Book Images [No restrictions], via Wikimedia Commons" href="https://commons.wikimedia.org/wiki/File%3AA_manual_of_syphilis_and_the_venereal_diseases%2C_(1900)_(14595882378).jpg"
- ↑ Feikin DR, Lezotte DC, Hamman RF, Salmon DA, Chen RT, Hoffman RE (2000). "Individual and community risks of measles and pertussis associated with personal exemptions to immunization". JAMA. 284 (24): 3145–50. PMID 11135778.
- ↑ Ratnam S, West R, Gadag V, Williams B, Oates E (1996). "Immunity against measles in school-aged children: implications for measles revaccination strategies". Can J Public Health. 87 (6): 407–10. PMID 9009400.