ThioTEPA

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Image:ThioTEPA.svg
ThioTEPA
Systematic (IUPAC) name
N,N ' N '-triethylenethiophosphoramide
Identifiers
CAS number	52-24-4
ATC code	L01AC01
PubChem	5453
Chemical data
Formula	C6H12N3PS
Mol. mass	189.219 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic (CYP2B6, CYP2C11)
Half life	2.4 hours 15-18 hours (metabolites)
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	D(AU) D(US)
Legal status	POM(UK) ℞-only(US)
Routes	IV, intracavitary, intravesical

WikiDoc Resources for ThioTEPA
Articles
Most recent articles on ThioTEPA Most cited articles on ThioTEPA Review articles on ThioTEPA Articles on ThioTEPA in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on ThioTEPA Images of ThioTEPA Photos of ThioTEPA Podcasts & MP3s on ThioTEPA Videos on ThioTEPA
Evidence Based Medicine
Cochrane Collaboration on ThioTEPA Bandolier on ThioTEPA TRIP on ThioTEPA
Clinical Trials
Ongoing Trials on ThioTEPA at Clinical Trials.gov Trial results on ThioTEPA Clinical Trials on ThioTEPA at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on ThioTEPA NICE Guidance on ThioTEPA NHS PRODIGY Guidance FDA on ThioTEPA CDC on ThioTEPA
Books
Books on ThioTEPA
News
ThioTEPA in the news Be alerted to news on ThioTEPA News trends on ThioTEPA
Commentary
Blogs on ThioTEPA
Definitions
Definitions of ThioTEPA
Patient Resources / Community
Patient resources on ThioTEPA Discussion groups on ThioTEPA Patient Handouts on ThioTEPA Directions to Hospitals Treating ThioTEPA Risk calculators and risk factors for ThioTEPA
Healthcare Provider Resources
Symptoms of ThioTEPA Causes & Risk Factors for ThioTEPA Diagnostic studies for ThioTEPA Treatment of ThioTEPA
Continuing Medical Education (CME)
CME Programs on ThioTEPA
International
ThioTEPA en Espanol ThioTEPA en Francais
Businness
ThioTEPA in the Marketplace Patents on ThioTEPA
Experimental / Informatics
List of terms related to ThioTEPA

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Overview

N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. It is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. It is also used as conditioning for Bone marrow transplantation. Its main toxicity is myelosuppression.

References

• Sykes M et al. (1953). "Clinical Studies of triethylenephosphoramide compounds with nitrogen mustard-like activity". Cancer 6: 142-48.
• Maanen MJ, Smeets CJ, Beijnen JH (2000). "Chemistry, pharmacology and pharmacokinetics of N,N',N" -triethylenethiophosphoramide (ThioTEPA)". Cancer Treat Rev 26 (4): 257-68. PMID 10913381.

v • d • e Chemotherapeutic agents/Antineoplastic agents (L01)
Alkylating and alkylating-like agents	Nitrogen mustards: (Chlorambucil, Chlormethine, Cyclophosphamide, Ifosfamide, Melphalan, Bendamustine, Uramustine) Nitrosoureas:(Carmustine, Fotemustine, Lomustine, Streptozocin) Platinum (alkylating-like): (Carboplatin, Cisplatin, Oxaliplatin, Triplatin tetranitrate, Satraplatin) Alkyl sulfonates:(Busulfan, Treosulfan) Hydrazines:(Procarbazine, Dacarbazine, Temozolomide) Aziridines:(ThioTEPA)
Antimetabolites	Folic acid: (Aminopterin, Methotrexate, Pemetrexed, Raltitrexed). Purine:(Cladribine, Clofarabine, Fludarabine, Mercaptopurine, Pentostatin, Thioguanine) Pyrimidine:(Capecitabine, Cytarabine, Decitabine, Fluorouracil, Floxuridine, Gemcitabine)
Spindle poison/mitotic inhibitor	Taxane: (Docetaxel, Larotaxel, Paclitaxel). Vinca: (Vinblastine, Vincristine, Vindesine, Vinorelbine).
Cytotoxic/antitumor antibiotics	Anthracycline family: (Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitoxantrone, Pixantrone, Valrubicin) streptomyces (Actinomycin, Bleomycin, Mitomycin, Plicamycin) - Hydroxyurea
Topoisomerase inhibitors	Camptotheca: (Camptothecin, Topotecan, Irinotecan, Rubitecan), Podophyllum:(Etoposide, Teniposide)
CI monoclonal antibodies	Receptor tyrosine kinase (Cetuximab, Panitumumab, Trastuzumab) - CD20 (Rituximab, Tositumomab) - other (Alemtuzumab, Bevacizumab, Gemtuzumab)
Photosensitizers	Aminolevulinic acid, Methyl aminolevulinate, Porfimer sodium, Verteporfin
Tyrosine kinase inhibitors	Axitinib, Bosutinib, Cediranib, Dasatinib, Erlotinib, Gefitinib, Imatinib, Lapatinib, Lestaurtinib, Nilotinib, Semaxanib, Sorafenib, Sunitinib, Vandetanib
Cyclin-dependent kinase inhibitor	Seliciclib
Other	retinoids (Alitretinoin, Tretinoin), Fusion protein (Aflibercept) - Altretamine, Amsacrine, Anagrelide, Arsenic trioxide, Asparaginase (Pegaspargase), Bexarotene, Bortezomib, Celecoxib, Denileukin diftitox, Elesclomol, Estramustine, Irofulven, Ixabepilone, Masoprocol, Mitotane, Oblimersen, Testolactone, Tipifarnib, Trabectedin

v • d • e WikiDoc Research Resources for ThioTEPA
Articles on ThioTEPA	Most recent articles on ThioTEPA • Most cited articles on ThioTEPA • Review articles on ThioTEPA • Articles on ThioTEPA in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on ThioTEPA	Powerpoint slides on ThioTEPA • Images of ThioTEPA • Photos of ThioTEPA • Podcasts & MP3s on ThioTEPA • Videos on ThioTEPA
Evidence Based Medicine Regarding ThioTEPA	Cochrane Collaboration on ThioTEPA • Bandolier on ThioTEPA • TRIP on ThioTEPA
Cost Effectiveness of ThioTEPA	Cost Effectiveness of ThioTEPA
Clinical Trials Involving ThioTEPA	Ongoing Trials on ThioTEPA at Clinical Trials.gov • Trial results on ThioTEPA • Clinical Trials on ThioTEPA at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding ThioTEPA	US National Guidelines Clearinghouse on ThioTEPA • NICE Guidance on ThioTEPA • NHS PRODIGY Guidance • FDA on ThioTEPA • CDC on ThioTEPA
Textbook Information on ThioTEPA	Books and Textbook Information on ThioTEPA
Pharmacology Resources on ThioTEPA	Dosing of ThioTEPA • Drug interactions with ThioTEPA • Side effects of ThioTEPA • Allergic reactions to ThioTEPA • Overdose information on ThioTEPA • Carcinogenicity information on ThioTEPA • ThioTEPA in pregnancy • Pharmacokinetics of ThioTEPA •
Genetics, Pharmacogenomics, and Proteinomics of ThioTEPA	Genetics of ThioTEPA • Pharmacogenomics of ThioTEPA • Proteomics of ThioTEPA
Newstories on ThioTEPA	ThioTEPA in the news • Be alerted to news on ThioTEPA • News trends on ThioTEPA
Commentary on ThioTEPA	Blogs on ThioTEPA
Patient Resources on ThioTEPA	Patient resources on ThioTEPA • Discussion groups on ThioTEPA • Patient Handouts on ThioTEPA • Directions to Hospitals Treating ThioTEPA • Risk calculators and risk factors for ThioTEPA
Healthcare Provider Resources on ThioTEPA	Symptoms of ThioTEPA • Causes & Risk Factors for ThioTEPA • Diagnostic studies for ThioTEPA • Treatment of ThioTEPA
Continuing Medical Education (CME) Programs on ThioTEPA	CME Programs on ThioTEPA
International Resources on ThioTEPA	ThioTEPA en Espanol • ThioTEPA en Francais
Business Resources on ThioTEPA	ThioTEPA in the Marketplace • Patents on ThioTEPA
Informatics Resources on ThioTEPA	List of terms related to ThioTEPA

de:Thiotepa

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