Tositumomab
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| Tositumomab?
| |
| Therapeutic monoclonal antibody | |
| Source | Mouse |
| Target | CD20 |
| Identifiers | |
| CAS number | |
| ATC code | V10 |
| PubChem | ? |
| DrugBank | |
| Chemical data | |
| Formula | C6416H9874N1688O1987S44 |
| Mol. mass | 143859.7 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Tositumomab is a monoclonal antibody derived from immortalized mouse cells. It is a IgG2a anti-CD20 antibody and is covalently bound to 131I. 131I emits both beta and gamma radiation and decays with a half-life of 8 days.
Clinical trials have established the efficacy of tositumomab in patients with relapsed or chemotherapy/rituxan refractory follicular lymphoma.
It is manufactured by Corixa. It sells in the U.S. under the trade name Bexxar.
Mouse monoclonal antibodies ("-o-") | |
|---|---|
| "govo" (ovarian tumor) | Abagovomab, Igovomab, Oregovomab |
| "limo" (immune system) | Afelimomab, Dorlimomab aritox, Elsilimomab, Faralimomab, Gavilimomab, Inolimomab, Maslimomab, Nerelimomab, Odulimomab, Telimomab aritox, Vepalimomab, Zolimomab aritox |
| "tumo" (miscellaneous tumor) | Altumomab, Anatumomab mafenatox, Arcitumomab, Bectumomab, Detumomab, Epitumomab, Epitumomab cituxetan, Ibritumomab tiuxetan, Minretumomab, Mitumomab, Naptumomab estafenatox, Nofetumomab merpentan, Pemtumomab, Pintumomab, Satumomab, Taplitumomab paptox, Tositumomab |
| "leso" (infectious lesions) | Besilesomab, Fanolesomab, Lemalesomab, Sulesomab |
| "ciro" (cardiovascular) | Biciromab brallobarbital, Imciromab |
| "pro" (prostate tumor) | Capromab |
| "baco" (bacterial) | Edobacomab |
| "colo" (colonic tumor) | Edrecolomab, Nacolomab tafenatox |
Radiopharmaceuticals (V09-V10) | |
|---|---|
| CI CD20 Antibodies | Tositumomab - Ibritumomab tiuxetan |
| Other | Sodium iodide - Iobenguane - Sodium phosphate - Sestamibi |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
