Amsacrine

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Amsacrine
Systematic (IUPAC) name
N-(4-(acridin-9-ylamino)-3-methoxyphenyl)methanesulfonamide
Identifiers
CAS number	51264-14-3
ATC code	L01XX01
PubChem	2179
DrugBank	APRD00064
Chemical data
Formula	C21H19N3O3S
Mol. mass	393.46 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	96 to 98%
Metabolism	?
Half life	8-9 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

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Articles
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Evidence Based Medicine
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Clinical Trials
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Commentary
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Definitions
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Patient Resources / Community
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Experimental / Informatics
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Overview

Amsacrine is an antineoplastic agent. Its planar fused ring system can intercalate into the DNA of tumor cells, thereby altering the major and minor groove proportions. These alterations to DNA structure inhibit both DNA replication and transcription by reducing association between the affected DNA and: DNA polymerase, RNA polymerase and transcription factors.

Amsacrine also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II (compares with the better known agent etoposide).