Tioguanine

Tioguanine
Systematic (IUPAC) name
2-amino-7H-purine-6-thiol
Identifiers
CAS number	154-42-7
ATC code	L01BB03
PubChem	2723601
DrugBank	APRD00290
Chemical data
Formula	C5H5N5S
Mol. mass	167.193 g/mol
Pharmacokinetic data
Bioavailability	30% (range 14% to 46%)
Metabolism	Intracellular
Half life	80 minutes (range 25-240 minutes)
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	oral

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Articles
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Media
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Evidence Based Medicine
Cochrane Collaboration on Tioguanine Bandolier on Tioguanine TRIP on Tioguanine
Clinical Trials
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Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Tioguanine NICE Guidance on Tioguanine NHS PRODIGY Guidance FDA on Tioguanine CDC on Tioguanine
Books
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News
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Commentary
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Definitions
Definitions of Tioguanine
Patient Resources / Community
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Healthcare Provider Resources
Symptoms of Tioguanine Causes & Risk Factors for Tioguanine Diagnostic studies for Tioguanine Treatment of Tioguanine
Continuing Medical Education (CME)
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International
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Business
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Experimental / Informatics
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Overview

Tioguanine (INN), formerly Thioguanine (BAN), is a drug that is used in the treatment of cancer. It belongs to the family of drugs called antimetabolites. It is a guanine analog. Its principal use is in acute leukaemias and chronic myeloid leukaemia.

Pharmacology

As a guanine analogue, it is transformed inside the cell into to 6-thioguanilyic acid (TGMP) which, by pseudofeedback interference with purine biosynthesis, interferes with the synthesis of guanine nucleotides. Some of its activity may also be due to the incorporation of thioguanine nucleotides into both RNA and DNA, but the end result is inducing cell cycle arrest and apoptosis. It is metabolized by via methylation by thiopurine methyltransferase.

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