Tioguanine

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Tioguanine
Systematic (IUPAC) name
2-amino-7H-purine-6-thiol
Identifiers
CAS number	154-42-7
ATC code	L01BB03
PubChem	2723601
DrugBank	APRD00290
Chemical data
Formula	C5H5N5S
Mol. mass	167.193 g/mol
Pharmacokinetic data
Bioavailability	30% (range 14% to 46%)
Metabolism	Intracellular
Half life	80 minutes (range 25-240 minutes)
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	oral

WikiDoc Resources for Tioguanine
Articles
Most recent articles on Tioguanine Most cited articles on Tioguanine Review articles on Tioguanine Articles on Tioguanine in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Tioguanine Images of Tioguanine Photos of Tioguanine Podcasts & MP3s on Tioguanine Videos on Tioguanine
Evidence Based Medicine
Cochrane Collaboration on Tioguanine Bandolier on Tioguanine TRIP on Tioguanine
Clinical Trials
Ongoing Trials on Tioguanine at Clinical Trials.gov Trial results on Tioguanine Clinical Trials on Tioguanine at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Tioguanine NICE Guidance on Tioguanine NHS PRODIGY Guidance FDA on Tioguanine CDC on Tioguanine
Books
Books on Tioguanine
News
Tioguanine in the news Be alerted to news on Tioguanine News trends on Tioguanine
Commentary
Blogs on Tioguanine
Definitions
Definitions of Tioguanine
Patient Resources / Community
Patient resources on Tioguanine Discussion groups on Tioguanine Patient Handouts on Tioguanine Directions to Hospitals Treating Tioguanine Risk calculators and risk factors for Tioguanine
Healthcare Provider Resources
Symptoms of Tioguanine Causes & Risk Factors for Tioguanine Diagnostic studies for Tioguanine Treatment of Tioguanine
Continuing Medical Education (CME)
CME Programs on Tioguanine
International
Tioguanine en Espanol Tioguanine en Francais
Businness
Tioguanine in the Marketplace Patents on Tioguanine
Experimental / Informatics
List of terms related to Tioguanine

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Overview

Tioguanine (INN), formerly Thioguanine (BAN), is a drug that is used in the treatment of cancer. It belongs to the family of drugs called antimetabolites. It is a guanine analog. Its principal use is in acute leukaemias and chronic myeloid leukaemia.

Pharmacology

As a guanine analogue, it is transformed inside the cell into to 6-thioguanilyic acid (TGMP) which, by pseudofeedback interference with purine biosynthesis, interferes with the synthesis of guanine nucleotides. Some of its activity may also be due to the incorporation of thioguanine nucleotides into both RNA and DNA, but the end result is inducing cell cycle arrest and apoptosis. It is metabolized by via methylation by thiopurine methyltransferase.

v • d • e Chemotherapeutic agents/Antineoplastic agents (L01)
Alkylating and alkylating-like agents	Nitrogen mustards: (Chlorambucil, Chlormethine, Cyclophosphamide, Ifosfamide, Melphalan, Bendamustine, Uramustine) Nitrosoureas:(Carmustine, Fotemustine, Lomustine, Streptozocin) Platinum (alkylating-like): (Carboplatin, Cisplatin, Oxaliplatin, Triplatin tetranitrate, Satraplatin) Alkyl sulfonates:(Busulfan, Treosulfan) Hydrazines:(Procarbazine, Dacarbazine, Temozolomide) Aziridines:(ThioTEPA)
Antimetabolites	Folic acid: (Aminopterin, Methotrexate, Pemetrexed, Raltitrexed). Purine:(Cladribine, Clofarabine, Fludarabine, Mercaptopurine, Pentostatin, Thioguanine) Pyrimidine:(Capecitabine, Cytarabine, Decitabine, Fluorouracil, Floxuridine, Gemcitabine)
Spindle poison/mitotic inhibitor	Taxane: (Docetaxel, Larotaxel, Paclitaxel). Vinca: (Vinblastine, Vincristine, Vindesine, Vinorelbine).
Cytotoxic/antitumor antibiotics	Anthracycline family: (Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitoxantrone, Pixantrone, Valrubicin) streptomyces (Actinomycin, Bleomycin, Mitomycin, Plicamycin) - Hydroxyurea
Topoisomerase inhibitors	Camptotheca: (Camptothecin, Topotecan, Irinotecan, Rubitecan), Podophyllum:(Etoposide, Teniposide)
CI monoclonal antibodies	Receptor tyrosine kinase (Cetuximab, Panitumumab, Trastuzumab) - CD20 (Rituximab, Tositumomab) - other (Alemtuzumab, Bevacizumab, Gemtuzumab)
Photosensitizers	Aminolevulinic acid, Methyl aminolevulinate, Porfimer sodium, Verteporfin
Tyrosine kinase inhibitors	Axitinib, Bosutinib, Cediranib, Dasatinib, Erlotinib, Gefitinib, Imatinib, Lapatinib, Lestaurtinib, Nilotinib, Semaxanib, Sorafenib, Sunitinib, Vandetanib
Cyclin-dependent kinase inhibitor	Seliciclib
Other	retinoids (Alitretinoin, Tretinoin), Fusion protein (Aflibercept) - Altretamine, Amsacrine, Anagrelide, Arsenic trioxide, Asparaginase (Pegaspargase), Bexarotene, Bortezomib, Celecoxib, Denileukin diftitox, Elesclomol, Estramustine, Irofulven, Ixabepilone, Masoprocol, Mitotane, Oblimersen, Testolactone, Tipifarnib, Trabectedin

v • d • e WikiDoc Research Resources for Tioguanine
Articles on Tioguanine	Most recent articles on Tioguanine • Most cited articles on Tioguanine • Review articles on Tioguanine • Articles on Tioguanine in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Tioguanine	Powerpoint slides on Tioguanine • Images of Tioguanine • Photos of Tioguanine • Podcasts & MP3s on Tioguanine • Videos on Tioguanine
Evidence Based Medicine Regarding Tioguanine	Cochrane Collaboration on Tioguanine • Bandolier on Tioguanine • TRIP on Tioguanine
Cost Effectiveness of Tioguanine	Cost Effectiveness of Tioguanine
Clinical Trials Involving Tioguanine	Ongoing Trials on Tioguanine at Clinical Trials.gov • Trial results on Tioguanine • Clinical Trials on Tioguanine at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Tioguanine	US National Guidelines Clearinghouse on Tioguanine • NICE Guidance on Tioguanine • NHS PRODIGY Guidance • FDA on Tioguanine • CDC on Tioguanine
Textbook Information on Tioguanine	Books and Textbook Information on Tioguanine
Pharmacology Resources on Tioguanine	Dosing of Tioguanine • Drug interactions with Tioguanine • Side effects of Tioguanine • Allergic reactions to Tioguanine • Overdose information on Tioguanine • Carcinogenicity information on Tioguanine • Tioguanine in pregnancy • Pharmacokinetics of Tioguanine •
Genetics, Pharmacogenomics, and Proteinomics of Tioguanine	Genetics of Tioguanine • Pharmacogenomics of Tioguanine • Proteomics of Tioguanine
Newstories on Tioguanine	Tioguanine in the news • Be alerted to news on Tioguanine • News trends on Tioguanine
Commentary on Tioguanine	Blogs on Tioguanine
Patient Resources on Tioguanine	Patient resources on Tioguanine • Discussion groups on Tioguanine • Patient Handouts on Tioguanine • Directions to Hospitals Treating Tioguanine • Risk calculators and risk factors for Tioguanine
Healthcare Provider Resources on Tioguanine	Symptoms of Tioguanine • Causes & Risk Factors for Tioguanine • Diagnostic studies for Tioguanine • Treatment of Tioguanine
Continuing Medical Education (CME) Programs on Tioguanine	CME Programs on Tioguanine
International Resources on Tioguanine	Tioguanine en Espanol • Tioguanine en Francais
Business Resources on Tioguanine	Tioguanine in the Marketplace • Patents on Tioguanine
Informatics Resources on Tioguanine	List of terms related to Tioguanine

de:Tioguanin

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