Oocyte
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| Oocyte | |
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| Diagram showing the reduction in number of the chromosomes in the process of maturation of the ovum. | |
| Gray's | subject #3 38 |
| MeSH | Oocytes |
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Overview
An oocyte, ovocyte, or rarely oöcyte, is a female gametocyte or germ cell involved in reproduction. In other words, it is an immature ovum. An oocyte is part the ovary development. The germ cells produce a primordial germ cell (PGC) which becomes an oogonia which marks the start of mitosis. After mitosis stops (due to actions of retinoic acid and the mesenephros) meiosis starts. This stage the oogonia is now an Oocyte (pronounced oh'a (like Noah)-site).
Formation
The formation of an oocyte is called oocytogenesis, which is a part of oogenesis[1]. Oogenesis results in the formation of both primary oocytes before birth, and of secondary oocytes after it as part of ovulation.
| Cell type | ploidy/chromosomes | chromatids | Process | Time of completion |
| Oogonium | diploid/46 | 2N | Oocytogenesis (mitosis) | third trimester |
| primary Oocyte | diploid/46 | 4N | Ootidogenesis (meiosis 1) (Folliculogenesis) | Dictyate in prophase I until ovulation |
| secondary Oocyte | haploid/23 | 2N | Ootidogenesis (meiosis 2) | Halted in metaphase II until fertilization |
| Ootid | haploid/23 | 1N | ? | Minutes after fertilization |
| Ovum | haploid/23 | 1N |
Characteristics
Cytoplasm
Oocytes are rich in cytoplasm which contains yolk granules to nourish the cell early in development.
Nucleus
During the primary oocyte stage of oogenesis, the nucleus is called a germinal vesicle[1]
The only normal type of secondary oocyte has sex chromosomes 23,X (where sperm can be 23,X or 23,Y).
Nest
The space wherein an ovum or immature ovum is located is the cell-nest[1].
Abnormalities
- nondisjunction -- a failure of proper homolog separation in meiosis I, or sister chromatid separation in meiosis II can lead to aneuploidy, in which the oocyte has the wrong number of chromosomes, for example 22,X or 24,X. This is the cause of conditions like Down syndrome and Edwards syndrome. It is more likely with advance maternal age.
- Some oocytes have multiple nuclei, although it is thought they never mature.
References
Resources
William K. Purves, Gordon H. Orians, David Sadava, H. Craig Heller, Craig Heller (2003). Life: The Science of Biology(7th ed.), pp. 823–824
See also
External links
cs:Vajíčkofr:Ovocyte
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
