High LDL causes: Difference between revisions
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==Overview== | ==Overview== | ||
High LDL | High LDL can be primary or secondary to [[Saturated fat|diet high in saturated fat]], [[hypothyroidism]], [[nephrotic syndrome]], [[pregnancy]], [[obesity]], or medications such as [[amiodarone]], [[cyclosporine]], [[diuretics]], and [[glucocorticoids]].<ref name="pmid24239923">{{cite journal| author=Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH et al.| title=2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. | journal=J Am Coll Cardiol | year= 2014 | volume= 63 | issue= 25 Pt B | pages= 2889-934 | pmid=24239923 | doi=10.1016/j.jacc.2013.11.002 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24239923 }} </ref> High LDL can also be caused by [[inherited]] diseases that affect the [[lipid metabolism]]. | ||
==Causes== | ==Causes== | ||
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* [[Obesity]] | * [[Obesity]] | ||
* [[Pregnancy]] | * [[Pregnancy]] | ||
* [[Weight gain]] | * [[Weight gain]]<ref name="pmid24239923">{{cite journal| author=Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH et al.| title=2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. | journal=J Am Coll Cardiol | year= 2014 | volume= 63 | issue= 25 Pt B | pages= 2889-934 | pmid=24239923 | doi=10.1016/j.jacc.2013.11.002 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24239923 }} </ref> | ||
===Causes by Organ System=== | ===Causes by Organ System=== | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Drug Side Effect''' | | '''Drug Side Effect''' | ||
|bgcolor="Beige"| [[Amiodarone]], [[atazanavir]], [[azathioprine]], [[bexarotene]], [[Immunosuppressive drug#Drugs acting on immunophilins|calcineurin inhibitors]], [[chlortalidone]], [[corticosteroids]], [[cyclosporine]], | |bgcolor="Beige"| [[Amiodarone]], [[atazanavir]], [[azathioprine]], [[bexarotene]], [[Immunosuppressive drug#Drugs acting on immunophilins|calcineurin inhibitors]], [[chlortalidone]], [[corticosteroids]], [[cyclosporine]], [[Dapagliflozin]], [[Danazol]], [[desvenlafaxine]], [[diuretics]], [[Fish oil|fish oil supplements]], [[glucocorticoid]], [[immunosuppressive agents]], [[levonorgestrel]], [[lopinavir]], [[Medroxyprogesterone acetate]], [[mycophenolate]], [[nicotine]], [[norgestrel]], [[Norgestrel and Ethinyl estradiol]], [[prednisone]], [[progestin]], [[rapamycin]], [[rosiglitazone]], [[sirolimus]], [[thiazide]], [[tocilizumab]] | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Gastroenterologic''' | | '''Gastroenterologic''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Biliary obstruction]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
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*[[Azathioprine]] | *[[Azathioprine]] | ||
*[[Bexarotene]] | *[[Bexarotene]] | ||
* [[Biliary obstruction]] | |||
*[[Immunosuppressive drug#Drugs acting on immunophilins|Calcineurin inhibitors]] | *[[Immunosuppressive drug#Drugs acting on immunophilins|Calcineurin inhibitors]] | ||
*[[Chenodeoxycholic acid]] | *[[Chenodeoxycholic acid]] | ||
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*[[Familial combined hyperlipidemia]] | *[[Familial combined hyperlipidemia]] | ||
*[[Apolipoprotein B deficiency|Familial defective apolipoprotein B-100]] | *[[Apolipoprotein B deficiency|Familial defective apolipoprotein B-100]] | ||
{{col-break|width=33%}} | |||
*[[Familial hypercholesterolemia]]<ref name="Durrington-2003">{{Cite journal | last1 = Durrington | first1 = P. | title = Dyslipidaemia. | journal = Lancet | volume = 362 | issue = 9385 | pages = 717-31 | month = Aug | year = 2003 | doi = 10.1016/S0140-6736(03)14234-1 | PMID = 12957096 }}</ref> | *[[Familial hypercholesterolemia]]<ref name="Durrington-2003">{{Cite journal | last1 = Durrington | first1 = P. | title = Dyslipidaemia. | journal = Lancet | volume = 362 | issue = 9385 | pages = 717-31 | month = Aug | year = 2003 | doi = 10.1016/S0140-6736(03)14234-1 | PMID = 12957096 }}</ref> | ||
*[[Fish oil|Fish oil supplements]]<ref name="Pejic-">{{Cite journal | last1 = Pejic | first1 = RN. | last2 = Lee | first2 = DT. | title = Hypertriglyceridemia. | journal = J Am Board Fam Med | volume = 19 | issue = 3 | pages = 310-6 | month = | year = | doi = | PMID = 16672684 }}</ref> | *[[Fish oil|Fish oil supplements]]<ref name="Pejic-">{{Cite journal | last1 = Pejic | first1 = RN. | last2 = Lee | first2 = DT. | title = Hypertriglyceridemia. | journal = J Am Board Fam Med | volume = 19 | issue = 3 | pages = 310-6 | month = | year = | doi = | PMID = 16672684 }}</ref> | ||
* [[Glucocorticoid]] | * [[Glucocorticoid]] | ||
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*[[Niemann-Pick disease]] | *[[Niemann-Pick disease]] | ||
*[[Norgestrel]] | *[[Norgestrel]] | ||
*[[Norgestrel and Ethinyl estradiol]] | |||
* [[Obesity]] | * [[Obesity]] | ||
*[[Xanthomatous biliary cirrhosis|Obstructive liver disease]] | *[[Xanthomatous biliary cirrhosis|Obstructive liver disease]] | ||
Latest revision as of 21:44, 16 January 2015
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High LDL causes On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Rim Halaby, M.D. [3]; Vendhan Ramanujam M.B.B.S [4]
Overview
High LDL can be primary or secondary to diet high in saturated fat, hypothyroidism, nephrotic syndrome, pregnancy, obesity, or medications such as amiodarone, cyclosporine, diuretics, and glucocorticoids.[1] High LDL can also be caused by inherited diseases that affect the lipid metabolism.
Causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
High LDL does not have any life-threatening cause.
Common Causes
- Amiodarone
- Anorexia
- Biliary obstruction
- Cyclosporine
- Diuretics
- Familial hypercholesterolemia[2]
- Glucocorticoids
- High saturated fat diet[3]
- Hypothyroidism
- Nephrotic syndrome
- Obesity
- Pregnancy
- Weight gain[1]
Causes by Organ System
Causes in Alphabetical Order
References
- ↑ 1.0 1.1 Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH; et al. (2014). "2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines". J Am Coll Cardiol. 63 (25 Pt B): 2889–934. doi:10.1016/j.jacc.2013.11.002. PMID 24239923.
- ↑ 2.0 2.1 Durrington, P. (2003). "Dyslipidaemia". Lancet. 362 (9385): 717–31. doi:10.1016/S0140-6736(03)14234-1. PMID 12957096. Unknown parameter
|month=ignored (help) - ↑ 3.0 3.1 Covington, MB. (2004). "Omega-3 fatty acids". Am Fam Physician. 70 (1): 133–40. PMID 15259529. Unknown parameter
|month=ignored (help) - ↑ Pejic, RN.; Lee, DT. "Hypertriglyceridemia". J Am Board Fam Med. 19 (3): 310–6. PMID 16672684.
- ↑ Kronenberg, F. (2005). "Dyslipidemia and nephrotic syndrome: recent advances". J Ren Nutr. 15 (2): 195–203. PMID 15827892. Unknown parameter
|month=ignored (help)