Low LDL causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Rim Halaby, M.D. [3]; Vendhan Ramanujam M.B.B.S [4]


Low LDL levels can be caused by unusual inherited disorders of lipoprotein metabolism such as abetalipoproteinemia and hypobetalipoproteinemia.


Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Low LDL does not have any life-threatening cause.

Common Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic Dyskeratosis congenita, lipomatosis of Madelung
Drug Side Effect Clofibrate, colesevelam hydrochlorie, colestyramine, doxazosin, nicotinic acid, NSAID, prazosin, probucol, statins
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental Ketogenic diet, malnutrition
Gastroenterologic Celiac disease, chronic liver disease, chronic pancreatitis, cirrhosis, Crohn's disease, exocrine pancreatic insufficiency, intestinal lymphangiectasia, liver failure, portosystemic shunts, protein losing enteropathy, short bowel syndrome
Genetic Abetalipoproteinemia, apolipoprotein B deficiency, Bassen-Kornzweig disease, cystic fibrosis, deficiency of proprotein convertase subtilisin-like/kexin type 9, dyskeratosis congenita, familial alphalipoprotein deficiency, familial hypobetalipoproteinemia, familial type 5 hyperlipoproteinemia, hypobetalipoproteinemia, lipoprotein lipase deficiency, mutations of the MTTP gene, Shwachman-Diamond syndrome
Hematologic Acute myeloid leukemia
Iatrogenic Portosystemic shunts, short bowel syndrome
Infectious Disease Giardiasis
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic Abetalipoproteinemia, apolipoprotein B deficiency, Bassen-Kornzweig disease, familial alphalipoprotein deficiency, familial hypobetalipoproteinemia, familial type 5 hyperlipoproteinemia, hypobetalipoproteinemia, lipoprotein lipase deficiency, mutations of the MTTP gene
Obstetric/Gynecologic No underlying causes
Oncologic Acute myeloid leukemia, malignancy
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy Acute phase proteins, amyloidosis, autoimmune diseases, celiac disease, inflammatory cytokines, high serum amyloid A, Sjögren's syndrome
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order


  1. Scanu, AM.; Aggerbeck, LP.; Kruski, AW.; Lim, CT.; Kayden, HJ. (1974). "A study of the abnormal lipoproteins in abetalipoproteinemia". J Clin Invest. 53 (2): 440–53. doi:10.1172/JCI107578. PMID 11344558. Unknown parameter |month= ignored (help)
  2. Welty, FK.; Mittleman, MA.; Wilson, PW.; Sutherland, PA.; Matheney, TH.; Lipinska, I.; Muller, JE.; Levy, D.; Tofler, GH. (1997). "Hypobetalipoproteinemia is associated with low levels of hemostatic risk factors in the Framingham offspring population". Circulation. 95 (4): 825–30. PMID 9054738. Unknown parameter |month= ignored (help)
  3. Sari I, Bakir S, Engin A, Aydin H, Poyraz O (2013). "Some acute phase reactants and cholesterol levels in serum of patient with Crimean-Congo haemorrhagic fever". Bosn J Basic Med Sci. 13 (1): 21–6. PMID 23448606.

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