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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1''' is a [[protein]] that in humans is encoded by the ''HCN1'' [[gene]].<ref name="pmid9405696">{{cite journal | vauthors = Santoro B, Grant SG, Bartsch D, Kandel ER | title = Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 26 | pages = 14815–20 | date = Dec 1997 | pmid = 9405696 | pmc = 25120 | doi = 10.1073/pnas.94.26.14815 }}</ref><ref name="pmid9630217">{{cite journal | vauthors = Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR | title = Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain | journal = Cell | volume = 93 | issue = 5 | pages = 717–29 | date = May 1998 | pmid = 9630217 | pmc =  | doi = 10.1016/S0092-8674(00)81434-8 }}</ref><ref name="pmid16382102">{{cite journal | vauthors = Hofmann F, Biel M, Kaupp UB | title = International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels | journal = Pharmacological Reviews | volume = 57 | issue = 4 | pages = 455–62 | date = Dec 2005 | pmid = 16382102 | pmc = | doi = 10.1124/pr.57.4.8 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=348980| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_HCN1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1q3e.
| PDB = {{PDB2|1q3e}}, {{PDB2|1q43}}, {{PDB2|1q5o}}
| Name = Hyperpolarization activated cyclic nucleotide-gated potassium channel 1
| HGNCid = 4845
| Symbol = HCN1
| AltSymbols =; BCNG-1; BCNG1; HAC-2
| OMIM = 602780
| ECnumber = 
| Homologene = 32093
| MGIid = 1096392
| GeneAtlas_image1 = PBB_GE_HCN1_gnf1h06726_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005249 |text = voltage-gated potassium channel activity}} {{GNF_GO|id=GO:0005272 |text = sodium channel activity}} {{GNF_GO|id=GO:0030552 |text = cAMP binding}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0030424 |text = axon}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 348980
    | Hs_Ensembl = ENSG00000164588
    | Hs_RefseqProtein = NP_066550
    | Hs_RefseqmRNA = NM_021072
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 45297730
    | Hs_GenLoc_end = 45731977
    | Hs_Uniprot = O60741
    | Mm_EntrezGene = 15165
    | Mm_Ensembl = ENSMUSG00000021730
    | Mm_RefseqmRNA = NM_010408
    | Mm_RefseqProtein = NP_034538
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 118721981
    | Mm_GenLoc_end = 119096083
    | Mm_Uniprot = O88704
  }}
}}
'''Hyperpolarization activated cyclic nucleotide-gated potassium channel 1''', also known as '''HCN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=348980| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[HCN channel|Hyperpolarization-activated cation channels]] of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.<ref name="entrez"/>
{{PBB_Summary
 
| section_title =
== Tissue distribution ==
| summary_text = Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=348980| accessdate = }}</ref>
HCN1 channel expression is found in the sinoatrial node,<ref name="MarionneauCouette2005">{{cite journal | vauthors = Marionneau C, Couette B, Liu J, Li H, Mangoni ME, Nargeot J, Lei M, Escande D, Demolombe S | title = Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart | journal = The Journal of Physiology | volume = 562 | issue = Pt 1 | pages = 223–34 | date = Jan 2005 | pmid = 15498808 | doi = 10.1113/jphysiol.2004.074047 | pmc=1665484}}</ref><ref name="ShiWymore1999">{{cite journal | vauthors = Shi W, Wymore R, Yu H, Wu J, Wymore RT, Pan Z, Robinson RB, Dixon JE, McKinnon D, Cohen IS | title = Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues | journal = Circulation Research | volume = 85 | issue = 1 | pages = e1–6 | date = Jul 1999 | pmid = 10400919 | doi = 10.1161/01.RES.85.1.e1 }}</ref> the neocortex, hippocampus, cerebellar cortex, dorsal root ganglion, trigeminal ganglion and brainstem.<ref name="LörinczNotomi2002">{{cite journal | vauthors = Lörincz A, Notomi T, Tamás G, Shigemoto R, Nusser Z | title = Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites | journal = Nature Neuroscience | volume = 5 | issue = 11 | pages = 1185–93 | date = Nov 2002 | pmid = 12389030 | doi = 10.1038/nn962 }}</ref><ref name="MilliganEdwards2006">{{cite journal | vauthors = Milligan CJ, Edwards IJ, Deuchars J | title = HCN1 ion channel immunoreactivity in spinal cord and medulla oblongata | journal = Brain Research | volume = 1081 | issue = 1 | pages = 79–91 | date = Apr 2006 | pmid = 16503331 | doi = 10.1016/j.brainres.2006.01.019 }}</ref><ref name="MoosmangBiel1999">{{cite journal | vauthors = Moosmang S, Biel M, Hofmann F, Ludwig A | title = Differential distribution of four hyperpolarization-activated cation channels in mouse brain | journal = Biological Chemistry | volume = 380 | issue = 7-8 | pages = 975–80 | year = 1999 | pmid = 10494850 | doi = 10.1515/BC.1999.121 }}</ref><ref name="WellsRowland2007">{{cite journal | vauthors = Wells JE, Rowland KC, Proctor EK | title = Hyperpolarization-activated channels in trigeminal ganglia innervating healthy and pulp-exposed teeth | journal = International Endodontic Journal | volume = 40 | issue = 9 | pages = 715–21 | date = Sep 2007 | pmid = 17645513 | doi = 10.1111/j.1365-2591.2007.01297.x }}</ref><ref>{{cite journal | vauthors = Santoro B, Grant SG, Bartsch D, Kandel ER | title = Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 26 | pages = 14815–20 | date = Dec 1997 | pmid = 9405696 | doi=10.1073/pnas.94.26.14815 | pmc=25120}}</ref>
}}
 
== Interactions ==
 
HCN1 has been shown to [[Protein-protein interaction|interact]] with [[HCN2]].<ref name = pmid12928435>{{cite journal | vauthors = Much B, Wahl-Schott C, Zong X, Schneider A, Baumann L, Moosmang S, Ludwig A, Biel M | title = Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels | journal = The Journal of Biological Chemistry | volume = 278 | issue = 44 | pages = 43781–6 | date = Oct 2003 | pmid = 12928435 | doi = 10.1074/jbc.M306958200 }}</ref><ref name = pmid12034718>{{cite journal | vauthors = Proenza C, Tran N, Angoli D, Zahynacz K, Balcar P, Accili EA | title = Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 29634–42 | date = Aug 2002 | pmid = 12034718 | doi = 10.1074/jbc.M200504200 }}</ref>
 
== Epilepsy ==
 
De novo mutations in HCN1 cause {{SWL|type=mutation_results_in|target=epilepsy|label=epilepsy}}.<ref name="pmid24747641">{{cite journal | vauthors = Nava C, Dalle C, Rastetter A, Striano P, de Kovel CG, Nabbout R, Cancès C, Ville D, Brilstra EH, Gobbi G, Raffo E, Bouteiller D, Marie Y, Trouillard O, Robbiano A, Keren B, Agher D, Roze E, Lesage S, Nicolas A, Brice A, Baulac M, Vogt C, El Hajj N, Schneider E, Suls A, Weckhuysen S, Gormley P, Lehesjoki AE, De Jonghe P, Helbig I, Baulac S, Zara F, Koeleman BP, Haaf T, LeGuern E, Depienne C | title = De novo mutations in HCN1 cause early infantile epileptic encephalopathy | journal = Nature Genetics | volume = 46 | issue = 6 | pages = 640–5 | date = Jun 2014 | pmid = 24747641 | doi = 10.1038/ng.2952 }}</ref>


==See also==
==See also==
Line 58: Line 21:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
| citations =
* {{cite journal | vauthors = Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M | title = A family of hyperpolarization-activated mammalian cation channels | journal = Nature | volume = 393 | issue = 6685 | pages = 587–91 | date = Jun 1998 | pmid = 9634236 | doi = 10.1038/31255 }}
*{{cite journal | author=Hofmann F, Biel M, Kaupp UB |title=International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 455-62 |year= 2006 |pmid= 16382102 |doi= 10.1124/pr.57.4.8 }}
* {{cite journal | vauthors = Kleiderlein JJ, Nisson PE, Jessee J, Li WB, Becker KG, Derby ML, Ross CA, Margolis RL | title = CCG repeats in cDNAs from human brain | journal = Human Genetics | volume = 103 | issue = 6 | pages = 666–73 | date = Dec 1998 | pmid = 9921901 | doi = 10.1007/s004390050889 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Ulens C, Tytgat J | title = Functional heteromerization of HCN1 and HCN2 pacemaker channels | journal = The Journal of Biological Chemistry | volume = 276 | issue = 9 | pages = 6069–72 | date = Mar 2001 | pmid = 11133998 | doi = 10.1074/jbc.C000738200 }}
*{{cite journal  | author=Santoro B, Grant SG, Bartsch D, Kandel ER |title=Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14815-20 |year= 1998 |pmid= 9405696 |doi=  }}
* {{cite journal | vauthors = Proenza C, Tran N, Angoli D, Zahynacz K, Balcar P, Accili EA | title = Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 29634–42 | date = Aug 2002 | pmid = 12034718 | doi = 10.1074/jbc.M200504200 }}
*{{cite journal | author=Santoro B, Liu DT, Yao H, ''et al.'' |title=Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. |journal=Cell |volume=93 |issue= 5 |pages= 717-29 |year= 1998 |pmid= 9630217 |doi=  }}
* {{cite journal | vauthors = Chaplan SR, Guo HQ, Lee DH, Luo L, Liu C, Kuei C, Velumian AA, Butler MP, Brown SM, Dubin AE | title = Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain | journal = The Journal of Neuroscience | volume = 23 | issue = 4 | pages = 1169–78 | date = Feb 2003 | pmid = 12598605 | doi =  }}
*{{cite journal  | author=Ludwig A, Zong X, Jeglitsch M, ''et al.'' |title=A family of hyperpolarization-activated mammalian cation channels. |journal=Nature |volume=393 |issue= 6685 |pages= 587-91 |year= 1998 |pmid= 9634236 |doi= 10.1038/31255 }}
* {{cite journal | vauthors = Lesso H, Li RA | title = Helical secondary structure of the external S3-S4 linker of pacemaker (HCN) channels revealed by site-dependent perturbations of activation phenotype | journal = The Journal of Biological Chemistry | volume = 278 | issue = 25 | pages = 22290–7 | date = Jun 2003 | pmid = 12668666 | doi = 10.1074/jbc.M302466200 }}
*{{cite journal | author=Kleiderlein JJ, Nisson PE, Jessee J, ''et al.'' |title=CCG repeats in cDNAs from human brain. |journal=Hum. Genet. |volume=103 |issue= 6 |pages= 666-73 |year= 1999 |pmid= 9921901 |doi= }}
* {{cite journal | vauthors = Bender RA, Soleymani SV, Brewster AL, Nguyen ST, Beck H, Mathern GW, Baram TZ | title = Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus | journal = The Journal of Neuroscience | volume = 23 | issue = 17 | pages = 6826–36 | date = Jul 2003 | pmid = 12890777 | doi =  }}
*{{cite journal | author=Ulens C, Tytgat J |title=Functional heteromerization of HCN1 and HCN2 pacemaker channels. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6069-72 |year= 2001 |pmid= 11133998 |doi= 10.1074/jbc.C000738200 }}
* {{cite journal | vauthors = Much B, Wahl-Schott C, Zong X, Schneider A, Baumann L, Moosmang S, Ludwig A, Biel M | title = Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels | journal = The Journal of Biological Chemistry | volume = 278 | issue = 44 | pages = 43781–6 | date = Oct 2003 | pmid = 12928435 | doi = 10.1074/jbc.M306958200 }}
*{{cite journal | author=Proenza C, Tran N, Angoli D, ''et al.'' |title=Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 29634-42 |year= 2002 |pmid= 12034718 |doi= 10.1074/jbc.M200504200 }}
* {{cite journal | vauthors = He C, Chen F, Li B, Hu Z | title = Neurophysiology of HCN channels: from cellular functions to multiple regulations | journal = Progress in Neurobiology | volume = 112 | pages = 1–23 | date = Jan 2014 | pmid = 24184323 | doi = 10.1016/j.pneurobio.2013.10.001 }}
*{{cite journal | author=Chaplan SR, Guo HQ, Lee DH, ''et al.'' |title=Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain. |journal=J. Neurosci. |volume=23 |issue= 4 |pages= 1169-78 |year= 2003 |pmid= 12598605 |doi=  }}
* {{cite journal | vauthors = Wahl-Schott C, Fenske S, Biel M | title = HCN channels: new roles in sinoatrial node function | journal = Current Opinion in Pharmacology | volume = 15 | pages = 83–90 | date = Apr 2014 | pmid = 24441197 | doi = 10.1016/j.coph.2013.12.005 }}
*{{cite journal | author=Lesso H, Li RA |title=Helical secondary structure of the external S3-S4 linker of pacemaker (HCN) channels revealed by site-dependent perturbations of activation phenotype. |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 22290-7 |year= 2003 |pmid= 12668666 |doi= 10.1074/jbc.M302466200 }}
*{{cite journal | author=Bender RA, Soleymani SV, Brewster AL, ''et al.'' |title=Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. |journal=J. Neurosci. |volume=23 |issue= 17 |pages= 6826-36 |year= 2003 |pmid= 12890777 |doi=  }}
*{{cite journal | author=Much B, Wahl-Schott C, Zong X, ''et al.'' |title=Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 43781-6 |year= 2003 |pmid= 12928435 |doi= 10.1074/jbc.M306958200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|HCN1+protein,+human}}
* {{MeshName|HCN1+protein,+human}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ion channels}}
{{PDB Gallery|geneid=348980}}
{{Ion channels|g4}}
 
[[Category:Ion channels]]
[[Category:Ion channels]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Latest revision as of 02:36, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 is a protein that in humans is encoded by the HCN1 gene.[1][2][3][4]

Function

Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.[4]

Tissue distribution

HCN1 channel expression is found in the sinoatrial node,[5][6] the neocortex, hippocampus, cerebellar cortex, dorsal root ganglion, trigeminal ganglion and brainstem.[7][8][9][10][11]

Interactions

HCN1 has been shown to interact with HCN2.[12][13]

Epilepsy

De novo mutations in HCN1 cause epilepsy .[14]

See also

References

  1. ↑ Santoro B, Grant SG, Bartsch D, Kandel ER (Dec 1997). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14815–20. doi:10.1073/pnas.94.26.14815. PMC 25120. PMID 9405696.
  2. ↑ Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR (May 1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell. 93 (5): 717–29. doi:10.1016/S0092-8674(00)81434-8. PMID 9630217.
  3. ↑ Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacological Reviews. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102.
  4. ↑ 4.0 4.1 "Entrez Gene: HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1".
  5. ↑ Marionneau C, Couette B, Liu J, Li H, Mangoni ME, Nargeot J, Lei M, Escande D, Demolombe S (Jan 2005). "Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart". The Journal of Physiology. 562 (Pt 1): 223–34. doi:10.1113/jphysiol.2004.074047. PMC 1665484. PMID 15498808.
  6. ↑ Shi W, Wymore R, Yu H, Wu J, Wymore RT, Pan Z, Robinson RB, Dixon JE, McKinnon D, Cohen IS (Jul 1999). "Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues". Circulation Research. 85 (1): e1–6. doi:10.1161/01.RES.85.1.e1. PMID 10400919.
  7. ↑ Lörincz A, Notomi T, Tamás G, Shigemoto R, Nusser Z (Nov 2002). "Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites". Nature Neuroscience. 5 (11): 1185–93. doi:10.1038/nn962. PMID 12389030.
  8. ↑ Milligan CJ, Edwards IJ, Deuchars J (Apr 2006). "HCN1 ion channel immunoreactivity in spinal cord and medulla oblongata". Brain Research. 1081 (1): 79–91. doi:10.1016/j.brainres.2006.01.019. PMID 16503331.
  9. ↑ Moosmang S, Biel M, Hofmann F, Ludwig A (1999). "Differential distribution of four hyperpolarization-activated cation channels in mouse brain". Biological Chemistry. 380 (7–8): 975–80. doi:10.1515/BC.1999.121. PMID 10494850.
  10. ↑ Wells JE, Rowland KC, Proctor EK (Sep 2007). "Hyperpolarization-activated channels in trigeminal ganglia innervating healthy and pulp-exposed teeth". International Endodontic Journal. 40 (9): 715–21. doi:10.1111/j.1365-2591.2007.01297.x. PMID 17645513.
  11. ↑ Santoro B, Grant SG, Bartsch D, Kandel ER (Dec 1997). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14815–20. doi:10.1073/pnas.94.26.14815. PMC 25120. PMID 9405696.
  12. ↑ Much B, Wahl-Schott C, Zong X, Schneider A, Baumann L, Moosmang S, Ludwig A, Biel M (Oct 2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels". The Journal of Biological Chemistry. 278 (44): 43781–6. doi:10.1074/jbc.M306958200. PMID 12928435.
  13. ↑ Proenza C, Tran N, Angoli D, Zahynacz K, Balcar P, Accili EA (Aug 2002). "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels". The Journal of Biological Chemistry. 277 (33): 29634–42. doi:10.1074/jbc.M200504200. PMID 12034718.
  14. ↑ Nava C, Dalle C, Rastetter A, Striano P, de Kovel CG, Nabbout R, Cancès C, Ville D, Brilstra EH, Gobbi G, Raffo E, Bouteiller D, Marie Y, Trouillard O, Robbiano A, Keren B, Agher D, Roze E, Lesage S, Nicolas A, Brice A, Baulac M, Vogt C, El Hajj N, Schneider E, Suls A, Weckhuysen S, Gormley P, Lehesjoki AE, De Jonghe P, Helbig I, Baulac S, Zara F, Koeleman BP, Haaf T, LeGuern E, Depienne C (Jun 2014). "De novo mutations in HCN1 cause early infantile epileptic encephalopathy". Nature Genetics. 46 (6): 640–5. doi:10.1038/ng.2952. PMID 24747641.

Further reading

  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M (Jun 1998). "A family of hyperpolarization-activated mammalian cation channels". Nature. 393 (6685): 587–91. doi:10.1038/31255. PMID 9634236.
  • Kleiderlein JJ, Nisson PE, Jessee J, Li WB, Becker KG, Derby ML, Ross CA, Margolis RL (Dec 1998). "CCG repeats in cDNAs from human brain". Human Genetics. 103 (6): 666–73. doi:10.1007/s004390050889. PMID 9921901.
  • Ulens C, Tytgat J (Mar 2001). "Functional heteromerization of HCN1 and HCN2 pacemaker channels". The Journal of Biological Chemistry. 276 (9): 6069–72. doi:10.1074/jbc.C000738200. PMID 11133998.
  • Proenza C, Tran N, Angoli D, Zahynacz K, Balcar P, Accili EA (Aug 2002). "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels". The Journal of Biological Chemistry. 277 (33): 29634–42. doi:10.1074/jbc.M200504200. PMID 12034718.
  • Chaplan SR, Guo HQ, Lee DH, Luo L, Liu C, Kuei C, Velumian AA, Butler MP, Brown SM, Dubin AE (Feb 2003). "Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain". The Journal of Neuroscience. 23 (4): 1169–78. PMID 12598605.
  • Lesso H, Li RA (Jun 2003). "Helical secondary structure of the external S3-S4 linker of pacemaker (HCN) channels revealed by site-dependent perturbations of activation phenotype". The Journal of Biological Chemistry. 278 (25): 22290–7. doi:10.1074/jbc.M302466200. PMID 12668666.
  • Bender RA, Soleymani SV, Brewster AL, Nguyen ST, Beck H, Mathern GW, Baram TZ (Jul 2003). "Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus". The Journal of Neuroscience. 23 (17): 6826–36. PMID 12890777.
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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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