KCNIP2

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Identifiers
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External IDsGeneCards: [1]
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SpeciesHumanMouse
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RefSeq (mRNA)

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Kv channel-interacting protein 2 also known as KChIP2 is a protein that in humans is encoded by the KCNIP2 gene.[1][2]

Function

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.[3] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[2]

See also

References

  1. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–6. doi:10.1038/35000592. PMID 10676964.
  2. 2.0 2.1 "Entrez Gene: KCNIP2 Kv channel interacting protein 2".
  3. Burgoyne RD (Mar 2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nature Reviews. Neuroscience. 8 (3): 182–93. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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