SCN4B

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Sodium channel β-subunit 4, also known as SCN4B or Naβ4, is an auxiliary sodium channel subunit that can alter the kinetics of sodium channels.[1] The protein is encoded by the SCN4B gene.[2] Mutations in the SCN4B are associated with long QT syndrome.[3]

SCN4B might additionally function as a cell adhesion molecule.[4][5]

See also

References

  1. Lewis, Amanda H.; Raman, Indira M. (2014-11-15). "Resurgent current of voltage-gated Na+ channels". The Journal of Physiology. 592 (22): 4825–4838. doi:10.1113/jphysiol.2014.277582. ISSN 1469-7793. PMC 4259529. PMID 25172941.
  2. "Entrez Gene: sodium channel".
  3. Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusié-Luna MT, Makielski JC, Ackerman MJ (July 2007). "SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome". Circulation. 116 (2): 134–42. doi:10.1161/CIRCULATIONAHA.106.659086. PMC 3332546. PMID 17592081.
  4. Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. doi:10.1038/srep26618.
  5. Shimizu, Hideaki (2017). "Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion". J Biol Chem. 27. doi:10.1074/jbc.M117.786509.

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