VDAC1

Jump to: navigation, search


Voltage-dependent anion channel 1
Identifiers
Symbols VDAC1 ; MGC111064; PORIN; PORIN-31-HL
External IDs OMIM: 604492 MGI106919 HomoloGene36115
RNA expression pattern
File:PBB GE VDAC1 212038 s at tn.png
File:PBB GE VDAC1 217140 s at tn.png
More reference expression data
Orthologs

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 7416
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 22333

|-

     | bgcolor="#C3FDB8" | Ensembl
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000073905
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSMUSG00000020402

|-

    | bgcolor="#C3FDB8" | Uniprot
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| P21796
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q3THL7

|-

    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_003374 (mRNA)
NP_003365 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |NM_011694 (mRNA)
NP_035824 (protein)

|-

    | bgcolor="#C3FDB8" | Location
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 5: 133.34 - 133.37 Mb 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 11: 52.2 -  52.23 Mb 

|-

|-

    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Voltage-dependent anion channel 1, also known as VDAC1, is a human gene.[1]


See also

References

  1. "Entrez Gene: VDAC1 voltage-dependent anion channel 1".

Further reading

  • Verrier F, Mignotte B, Jan G, Brenner C (2004). "Study of PTPC composition during apoptosis for identification of viral protein target". Ann. N. Y. Acad. Sci. 1010: 126–42. PMID 15033708.
  • McEnery MW, Snowman AM, Trifiletti RR, Snyder SH (1992). "Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier". Proc. Natl. Acad. Sci. U.S.A. 89 (8): 3170–4. PMID 1373486.
  • Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. PMID 1602151.
  • Jürgens L, Ilsemann P, Kratzin HD; et al. (1991). "Studies on human porin. IV. The primary structures of "Porin 31HM" purified from human skeletal muscle membranes and of "Porin 31HL" derived from human B lymphocyte membranes are identical". Biol. Chem. Hoppe-Seyler. 372 (7): 455–63. PMID 1657034.
  • Kayser H, Kratzin HD, Thinnes FP; et al. (1990). "[Identification of human porins. II. Characterization and primary structure of a 31-lDa porin from human B lymphocytes (Porin 31HL).]". Biol. Chem. Hoppe-Seyler. 370 (12): 1265–78. PMID 2559745.
  • Blachly-Dyson E, Baldini A, Litt M; et al. (1994). "Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms". Genomics. 20 (1): 62–7. doi:10.1006/geno.1994.1127. PMID 7517385.
  • Brdiczka D, Kaldis P, Wallimann T (1994). "In vitro complex formation between the octamer of mitochondrial creatine kinase and porin". J. Biol. Chem. 269 (44): 27640–4. PMID 7525559.
  • Yu WH, Wolfgang W, Forte M (1995). "Subcellular localization of human voltage-dependent anion channel isoforms". J. Biol. Chem. 270 (23): 13998–4006. PMID 7539795.
  • Thomas L, Blachly-Dyson E, Colombini M, Forte M (1993). "Mapping of residues forming the voltage sensor of the voltage-dependent anion-selective channel". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5446–9. PMID 7685903.
  • Blachly-Dyson E, Zambronicz EB, Yu WH; et al. (1993). "Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel". J. Biol. Chem. 268 (3): 1835–41. PMID 8420959.
  • Schleiff E, Shore GC, Goping IS (1997). "Human mitochondrial import receptor, Tom20p. Use of glutathione to reveal specific interactions between Tom20-glutathione S-transferase and mitochondrial precursor proteins". FEBS Lett. 404 (2–3): 314–8. PMID 9119086.
  • Reymann S, Haase W, Krick W; et al. (1998). "Endosomes: another extra-mitochondrial location of type-1 porin/voltage-dependent anion-selective channels". Pflugers Arch. 436 (3): 478–80. PMID 9644232.
  • Narita M, Shimizu S, Ito T; et al. (1999). "Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria". Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14681–6. PMID 9843949.
  • Crompton M, Virji S, Ward JM (1999). "Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore". Eur. J. Biochem. 258 (2): 729–35. PMID 9874241.
  • Messina A, Oliva M, Rosato C; et al. (1999). "Mapping of the human Voltage-Dependent Anion Channel isoforms 1 and 2 reconsidered". Biochem. Biophys. Res. Commun. 255 (3): 707–10. doi:10.1006/bbrc.1998.0136. PMID 10049775.
  • Shimizu S, Narita M, Tsujimoto Y (1999). "Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC". Nature. 399 (6735): 483–7. doi:10.1038/20959. PMID 10365962.
  • Decker WK, Bowles KR, Schatte EC; et al. (2000). "Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis". Mamm. Genome. 10 (10): 1041–2. PMID 10501981.
  • Jacotot E, Ravagnan L, Loeffler M; et al. (2000). "The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore". J. Exp. Med. 191 (1): 33–46. PMID 10620603.
  • Shimizu S, Tsujimoto Y (2000). "Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity". Proc. Natl. Acad. Sci. U.S.A. 97 (2): 577–82. PMID 10639121.
  • Stadtmüller U, Eben-Brunnen J, Schmid A; et al. (2000). "Mitochondria-derived and extra-mitochondrial human type-1 porin are identical as revealed by amino acid sequencing and electrophysiological characterisation". Biol. Chem. 380 (12): 1461–6. PMID 10661876.

External links



Linked-in.jpg