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{{Infobox_gene}}
{{PBB_Controls
'''Voltage-dependent calcium channel subunit alpha-2/delta-1''' is a [[protein]] that in humans is encoded by the ''CACNA2D1'' [[gene]].<ref name="pmid8188232">{{cite journal | vauthors = Powers PA, Scherer SW, Tsui LC, Gregg RG, Hogan K | title = Localization of the gene encoding the alpha 2/delta subunit (CACNL2A) of the human skeletal muscle voltage-dependent Ca2+ channel to chromosome 7q21-q22 by somatic cell hybrid analysis | journal = Genomics | volume = 19 | issue = 1 | pages = 192–3 |date=Jun 1994 | pmid = 8188232 | pmc =  | doi = 10.1006/geno.1994.1044 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=781| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Calcium channel, voltage-dependent, alpha 2/delta subunit 1
| HGNCid = 1399
| Symbol = CACNA2D1
| AltSymbols =; CACNA2; CACNL2A; CCHL2A; MHS3
| OMIM = 114204
| ECnumber = 
| Homologene = 579
| MGIid = 88295
| GeneAtlas_image1 = PBB_GE_CACNA2D1_207050_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0015270 |text = dihydropyridine-sensitive calcium channel activity}}
| Component = {{GNF_GO|id=GO:0005891 |text = voltage-gated calcium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 781
    | Hs_Ensembl = ENSG00000153956
    | Hs_RefseqProtein = NP_000713
    | Hs_RefseqmRNA = NM_000722
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 81417354
    | Hs_GenLoc_end = 81910967
    | Hs_Uniprot = P54289
    | Mm_EntrezGene = 12293
    | Mm_Ensembl = ENSMUSG00000040118
    | Mm_RefseqmRNA = NM_009784
    | Mm_RefseqProtein = NP_033914
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 15446612
    | Mm_GenLoc_end = 15882893
    | Mm_Uniprot = Q8C6Y3
  }}
}}
'''Calcium channel, voltage-dependent, alpha 2/delta subunit 1''', also known as '''CACNA2D1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=781| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.<ref name="entrez">{{cite web | title = Entrez Gene: CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=781| accessdate = }}</ref>
| summary_text = This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional [[splice variant]]s of this gene have been observed but have not been thoroughly characterized.<ref name="entrez"/>
}}
}}
==Gabapentinoids==
alpha2/delta proteins are believed to be the molecular target of the [[gabapentinoid]]s [[gabapentin]] and [[pregabalin]], which are used to treat [[epilepsy]] and [[neuropathic pain]].<ref>{{cite journal | vauthors =Rogawski MA, Bazil CW | title = New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels | journal = Curr Neurol Neurosci Rep | date = July 2008 | volume = 8 | issue = 4 | pages = 345–52 | pmid = 18590620 | doi=10.1007/s11910-008-0053-7 | pmc=2587091}}</ref><ref>{{Cite journal|last=Patel|first=Ryan|last2=Dickenson|first2=Anthony H.|date=2016-04-01|title=Mechanisms of the gabapentinoids andα2δ-1 calcium channel subunit in neuropathic pain|url=http://doi.wiley.com/10.1002/prp2.205|journal=Pharmacology Research & Perspectives|language=en|volume=4|issue=2|doi=10.1002/prp2.205|issn=2052-1707}}</ref><ref>{{Cite journal|last=Patel|first=Ryan|last2=Bauer|first2=Claudia S.|last3=Nieto-Rostro|first3=Manuela|last4=Margas|first4=Wojciech|last5=Ferron|first5=Laurent|last6=Chaggar|first6=Kanchan|last7=Crews|first7=Kasumi|last8=Ramirez|first8=Juan D.|last9=Bennett|first9=David L. H.|date=2013-10-16|title=α2δ-1 Gene Deletion Affects Somatosensory Neuron Function and Delays Mechanical Hypersensitivity in Response to Peripheral Nerve Damage|url=http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.1026-13.2013|journal=Journal of Neuroscience|volume=33|issue=42|pages=16412–16426|doi=10.1523/jneurosci.1026-13.2013|pmc=3797367}}</ref>


==See also==
==See also==
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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Williams ME, Feldman DH, McCue AF, ''et al.'' |title=Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype. |journal=Neuron |volume=8 |issue= 1 |pages= 71-84 |year= 1992 |pmid= 1309651 |doi=  }}
*{{cite journal  | vauthors=Williams ME, Feldman DH, McCue AF |title=Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype. |journal=Neuron |volume=8 |issue= 1 |pages= 71–84 |year= 1992 |pmid= 1309651 |doi=10.1016/0896-6273(92)90109-Q |display-authors=etal}}
*{{cite journal  | author=Ellis SB, Williams ME, Ways NR, ''et al.'' |title=Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel. |journal=Science |volume=241 |issue= 4873 |pages= 1661-4 |year= 1988 |pmid= 2458626 |doi=  }}
*{{cite journal  | vauthors=Ellis SB, Williams ME, Ways NR |title=Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel. |journal=Science |volume=241 |issue= 4873 |pages= 1661–4 |year= 1988 |pmid= 2458626 |doi=10.1126/science.2458626 |display-authors=etal}}
*{{cite journal  | author=Iles DE, Lehmann-Horn F, Scherer SW, ''et al.'' |title=Localization of the gene encoding the alpha 2/delta-subunits of the L-type voltage-dependent calcium channel to chromosome 7q and analysis of the segregation of flanking markers in malignant hyperthermia susceptible families. |journal=Hum. Mol. Genet. |volume=3 |issue= 6 |pages= 969-75 |year= 1994 |pmid= 7951247 |doi=  }}
*{{cite journal  | vauthors=Iles DE, Lehmann-Horn F, Scherer SW |title=Localization of the gene encoding the alpha 2/delta-subunits of the L-type voltage-dependent calcium channel to chromosome 7q and analysis of the segregation of flanking markers in malignant hyperthermia susceptible families. |journal=Hum. Mol. Genet. |volume=3 |issue= 6 |pages= 969–75 |year= 1994 |pmid= 7951247 |doi=10.1093/hmg/3.6.969 |display-authors=etal}}
*{{cite journal  | author=Brust PF, Simerson S, McCue AF, ''et al.'' |title=Human neuronal voltage-dependent calcium channels: studies on subunit structure and role in channel assembly. |journal=Neuropharmacology |volume=32 |issue= 11 |pages= 1089-102 |year= 1994 |pmid= 8107964 |doi= }}
*{{cite journal  | vauthors=Brust PF, Simerson S, McCue AF |title=Human neuronal voltage-dependent calcium channels: studies on subunit structure and role in channel assembly. |journal=Neuropharmacology |volume=32 |issue= 11 |pages= 1089–102 |year= 1994 |pmid= 8107964 |doi=10.1016/0028-3908(93)90004-M  |display-authors=etal}}
*{{cite journal  | author=Powers PA, Scherer SW, Tsui LC, ''et al.'' |title=Localization of the gene encoding the alpha 2/delta subunit (CACNL2A) of the human skeletal muscle voltage-dependent Ca2+ channel to chromosome 7q21-q22 by somatic cell hybrid analysis. |journal=Genomics |volume=19 |issue= 1 |pages= 192-3 |year= 1994 |pmid= 8188232 |doi= 10.1006/geno.1994.1044 }}
*{{cite journal  |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=  10.1101/gr.8.11.1097}}
*{{cite journal  | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi=  }}
*{{cite journal  | vauthors=Schleithoff L, Mehrke G, Reutlinger B, Lehmann-Horn F |title=Genomic structure and functional expression of a human alpha(2)/delta calcium channel subunit gene (CACNA2). |journal=Genomics |volume=61 |issue= 2 |pages= 201–9 |year= 1999 |pmid= 10534405 |doi= 10.1006/geno.1999.5941 }}
*{{cite journal  | author=Schleithoff L, Mehrke G, Reutlinger B, Lehmann-Horn F |title=Genomic structure and functional expression of a human alpha(2)/delta calcium channel subunit gene (CACNA2). |journal=Genomics |volume=61 |issue= 2 |pages= 201-9 |year= 1999 |pmid= 10534405 |doi= 10.1006/geno.1999.5941 }}
*{{cite journal  | vauthors=Bell DC, Butcher AJ, Berrow NS |title=Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents. |journal=J. Neurophysiol. |volume=85 |issue= 2 |pages= 816–27 |year= 2001 |pmid= 11160515 |doi=  |display-authors=etal}}
*{{cite journal  | author=Bell DC, Butcher AJ, Berrow NS, ''et al.'' |title=Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents. |journal=J. Neurophysiol. |volume=85 |issue= 2 |pages= 816-27 |year= 2001 |pmid= 11160515 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Hillier LW, Fulton RS, Fulton LA |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |display-authors=etal}}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | vauthors=Stotz SC, Barr W, McRory JE |title=Several structural domains contribute to the regulation of N-type calcium channel inactivation by the beta 3 subunit. |journal=J. Biol. Chem. |volume=279 |issue= 5 |pages= 3793–800 |year= 2004 |pmid= 14602720 |doi= 10.1074/jbc.M308991200 |display-authors=etal}}
*{{cite journal  | author=Stotz SC, Barr W, McRory JE, ''et al.'' |title=Several structural domains contribute to the regulation of N-type calcium channel inactivation by the beta 3 subunit. |journal=J. Biol. Chem. |volume=279 |issue= 5 |pages= 3793-800 |year= 2004 |pmid= 14602720 |doi= 10.1074/jbc.M308991200 }}
*{{cite journal  | vauthors=Liu T, Qian WJ, Gritsenko MA |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 |display-authors=etal}}
*{{cite journal  | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
*{{cite journal  | vauthors=Antzelevitch C, Pollevick GD, Cordeiro JM |title=Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. |journal=Circulation |volume=115 |issue= 4 |pages= 442–9 |year= 2007 |pmid= 17224476 |doi= 10.1161/CIRCULATIONAHA.106.668392 | pmc=1952683 |display-authors=etal}}
*{{cite journal  | author=Antzelevitch C, Pollevick GD, Cordeiro JM, ''et al.'' |title=Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. |journal=Circulation |volume=115 |issue= 4 |pages= 442-9 |year= 2007 |pmid= 17224476 |doi= 10.1161/CIRCULATIONAHA.106.668392 }}
*{{cite journal  | vauthors=Chaudhuri D, Issa JB, Yue DT |title=Elementary mechanisms producing facilitation of Cav2.1 (P/Q-type) channels. |journal=J. Gen. Physiol. |volume=129 |issue= 5 |pages= 385–401 |year= 2007 |pmid= 17438119 |doi= 10.1085/jgp.200709749 | pmc=2154375 }}
*{{cite journal  | author=Chaudhuri D, Issa JB, Yue DT |title=Elementary mechanisms producing facilitation of Cav2.1 (P/Q-type) channels. |journal=J. Gen. Physiol. |volume=129 |issue= 5 |pages= 385-401 |year= 2007 |pmid= 17438119 |doi= 10.1085/jgp.200709749 }}
}}
}}
{{refend}}
{{refend}}
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== External links ==
== External links ==
* {{MeshName|CACNA2D1+protein,+human}}
* {{MeshName|CACNA2D1+protein,+human}}
* {{UCSC gene info|CACNA2D1}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ion channels}}
{{Ion channels|g1}}
 
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[[Category:Ion channels]]
[[Category:Ion channels]]
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Latest revision as of 19:11, 15 May 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

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n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Voltage-dependent calcium channel subunit alpha-2/delta-1 is a protein that in humans is encoded by the CACNA2D1 gene.[1][2]

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[2]

Gabapentinoids

alpha2/delta proteins are believed to be the molecular target of the gabapentinoids gabapentin and pregabalin, which are used to treat epilepsy and neuropathic pain.[3][4][5]

See also

References

  1. ↑ Powers PA, Scherer SW, Tsui LC, Gregg RG, Hogan K (Jun 1994). "Localization of the gene encoding the alpha 2/delta subunit (CACNL2A) of the human skeletal muscle voltage-dependent Ca2+ channel to chromosome 7q21-q22 by somatic cell hybrid analysis". Genomics. 19 (1): 192–3. doi:10.1006/geno.1994.1044. PMID 8188232.
  2. ↑ 2.0 2.1 "Entrez Gene: CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1".
  3. ↑ Rogawski MA, Bazil CW (July 2008). "New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels". Curr Neurol Neurosci Rep. 8 (4): 345–52. doi:10.1007/s11910-008-0053-7. PMC 2587091. PMID 18590620.
  4. ↑ Patel, Ryan; Dickenson, Anthony H. (2016-04-01). "Mechanisms of the gabapentinoids andα2δ-1 calcium channel subunit in neuropathic pain". Pharmacology Research & Perspectives. 4 (2). doi:10.1002/prp2.205. ISSN 2052-1707.
  5. ↑ Patel, Ryan; Bauer, Claudia S.; Nieto-Rostro, Manuela; Margas, Wojciech; Ferron, Laurent; Chaggar, Kanchan; Crews, Kasumi; Ramirez, Juan D.; Bennett, David L. H. (2013-10-16). "α2δ-1 Gene Deletion Affects Somatosensory Neuron Function and Delays Mechanical Hypersensitivity in Response to Peripheral Nerve Damage". Journal of Neuroscience. 33 (42): 16412–16426. doi:10.1523/jneurosci.1026-13.2013. PMC 3797367.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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