AQP5: Difference between revisions

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Latest revision as of 14:22, 4 November 2018

Aquaporin-5 is a protein that in humans is encoded by the AQP5 gene.^[1]^[2]

Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions ^[2]. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.^[2]

References

↑ Lee MD, Bhakta KY, Raina S, Yonescu R, Griffin CA, Copeland NG, Gilbert DJ, Jenkins NA, Preston GM, Agre P (Jun 1996). "The human Aquaporin-5 gene. Molecular characterization and chromosomal localization". J Biol Chem. 271 (15): 8599–604. doi:10.1074/jbc.271.15.8599. PMID 8621489.
↑ ^2.0 ^2.1 ^2.2 "Entrez Gene: AQP5 aquaporin 5".

Verkman AS (2003). "Role of aquaporin water channels in eye function". Exp. Eye Res. 76 (2): 137–43. doi:10.1016/S0014-4835(02)00303-2. PMID 12565800.
Ma T, Yang B, Umenishi F, Verkman AS (1997). "Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13". Genomics. 43 (3): 387–9. doi:10.1006/geno.1997.4836. PMID 9268644.
Smith JK, Siddiqui AA, Modica LA, et al. (1999). "Interferon-alpha upregulates gene expression of aquaporin-5 in human parotid glands". J. Interferon Cytokine Res. 19 (8): 929–35. doi:10.1089/107999099313479. PMID 10476940.
Kreda SM, Gynn MC, Fenstermacher DA, et al. (2001). "Expression and localization of epithelial aquaporins in the adult human lung". Am. J. Respir. Cell Mol. Biol. 24 (3): 224–34. doi:10.1165/ajrcmb.24.3.4367. PMID 11245621.
Gresz V, Kwon TH, Hurley PT, et al. (2001). "Identification and localization of aquaporin water channels in human salivary glands". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G247–54. PMID 11408278.
Nejsum LN, Kwon TH, Jensen UB, et al. (2002). "Functional requirement of aquaporin-5 in plasma membranes of sweat glands". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 511–6. doi:10.1073/pnas.012588099. PMC 117591. PMID 11773623.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Burghardt B, Elkaer ML, Kwon TH, et al. (2003). "Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas". Gut. 52 (7): 1008–16. doi:10.1136/gut.52.7.1008. PMC 1773699. PMID 12801959.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Chen Z, Wang X, Gao L, et al. (2006). "Regulation of MUC5AC mucin secretion by depletion of AQP5 in SPC-A1 cells". Biochem. Biophys. Res. Commun. 342 (3): 775–81. doi:10.1016/j.bbrc.2006.01.103. PMID 16500622.
Sidhaye VK, Güler AD, Schweitzer KS, et al. (2006). "Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions". Proc. Natl. Acad. Sci. U.S.A. 103 (12): 4747–52. doi:10.1073/pnas.0511211103. PMC 1450241. PMID 16537379.
Pedersen PS, Braunstein TH, Jørgensen A, et al. (2007). "Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stress". Pflügers Arch. 453 (6): 777–85. doi:10.1007/s00424-006-0157-3. PMID 17043812.
Skowron-zwarg M, Boland S, Caruso N, et al. (2007). "Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation". Exp. Cell Res. 313 (12): 2695–702. doi:10.1016/j.yexcr.2007.02.035. PMID 17553491.

External links

AQP5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
Human AQP5 genome location and AQP5 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[pmid8621489-1] Lee MD, Bhakta KY, Raina S, Yonescu R, Griffin CA, Copeland NG, Gilbert DJ, Jenkins NA, Preston GM, Agre P (Jun 1996). "The human Aquaporin-5 gene. Molecular characterization and chromosomal localization". J Biol Chem. 271 (15): 8599–604. doi:10.1074/jbc.271.15.8599. PMID 8621489.

[entrez-2] 2.0 ^2.1 ^2.2 "Entrez Gene: AQP5 aquaporin 5".

[1]

[2]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{PBB_Controls
+'''Aquaporin-5''' is a [[protein]] that in humans is encoded by the ''AQP5'' [[gene]].<ref name="pmid8621489">{{cite journal |vauthors=Lee MD, Bhakta KY, Raina S, Yonescu R, Griffin CA, Copeland NG, Gilbert DJ, Jenkins NA, Preston GM, Agre P | title = The human Aquaporin-5 gene. Molecular characterization and chromosomal localization | journal = J Biol Chem | volume = 271 | issue = 15 | pages = 8599–604 |date=Jun 1996 | pmid = 8621489 | pmc =  | doi =  10.1074/jbc.271.15.8599}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AQP5 aquaporin 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=362| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Aquaporin 5
- | HGNCid = 638
- | Symbol = AQP5
- | AltSymbols =;
- | OMIM = 600442
- | ECnumber =
- | Homologene = 20398
- | MGIid = 106215
- | GeneAtlas_image1 = PBB_GE_AQP5_213611_at_tn.png
- | Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0015250 |text = water channel activity}}
- | Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0005902 |text = microvillus}} {{GNF_GO|id=GO:0009925 |text = basal plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016324 |text = apical plasma membrane}}
-  | Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006833 |text = water transport}} {{GNF_GO|id=GO:0007588 |text = excretion}}
-  | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 362
-    | Hs_Ensembl = ENSG00000161798
-    | Hs_RefseqProtein = NP_001642
-    | Hs_RefseqmRNA = NM_001651
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 12
-    | Hs_GenLoc_start = 48641920
-    | Hs_GenLoc_end = 48645701
-    | Hs_Uniprot = P55064
-    | Mm_EntrezGene = 11830
-    | Mm_Ensembl = ENSMUSG00000044217
-    | Mm_RefseqmRNA = XM_001003734
-    | Mm_RefseqProtein = XP_001003734
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 15
-    | Mm_GenLoc_start = 99418814
-    | Mm_GenLoc_end = 99422858
-    | Mm_Uniprot = Q9WTY4
-  }}
-}}
-'''Aquaporin 5''', also known as '''AQP5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AQP5 aquaporin 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=362| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = Aquaporin 5 (AQP5) is a water channel protein.  Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.<ref name="entrez">{{cite web | title = Entrez Gene: AQP5 aquaporin 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=362| accessdate = }}</ref>
+| summary_text = Aquaporin 5 (AQP5) is a water channel protein.  Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions <ref name="entrez"/>. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.<ref name="entrez"/>
 }}
@@ Line 58: / Line 12: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 64: / Line 18: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Verkman AS |title=Role of aquaporin water channels in eye function. |journal=Exp. Eye Res. |volume=76 |issue= 2 |pages= 137-43 |year= 2003 |pmid= 12565800 |doi=  }}
+*{{cite journal  | author=Verkman AS |title=Role of aquaporin water channels in eye function. |journal=Exp. Eye Res. |volume=76 |issue= 2 |pages= 137–43 |year= 2003 |pmid= 12565800 |doi=10.1016/S0014-4835(02)00303-2  }}
-*{{cite journal  | author=Lee MD, Bhakta KY, Raina S, ''et al.'' |title=The human Aquaporin-5 gene. Molecular characterization and chromosomal localization. |journal=J. Biol. Chem. |volume=271 |issue= 15 |pages= 8599-604 |year= 1996 |pmid= 8621489 |doi=  }}
+*{{cite journal  |vauthors=Ma T, Yang B, Umenishi F, Verkman AS |title=Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13. |journal=Genomics |volume=43 |issue= 3 |pages= 387–9 |year= 1997 |pmid= 9268644 |doi= 10.1006/geno.1997.4836 }}
-*{{cite journal  | author=Ma T, Yang B, Umenishi F, Verkman AS |title=Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13. |journal=Genomics |volume=43 |issue= 3 |pages= 387-9 |year= 1997 |pmid= 9268644 |doi= 10.1006/geno.1997.4836 }}
+*{{cite journal  |vauthors=Smith JK, Siddiqui AA, Modica LA |title=Interferon-alpha upregulates gene expression of aquaporin-5 in human [[parotid gland]]s. |journal=J. Interferon Cytokine Res. |volume=19 |issue= 8 |pages= 929–35 |year= 1999 |pmid= 10476940 |doi= 10.1089/107999099313479 |display-authors=etal}}
-*{{cite journal  | author=Smith JK, Siddiqui AA, Modica LA, ''et al.'' |title=Interferon-alpha upregulates gene expression of aquaporin-5 in human parotid glands. |journal=J. Interferon Cytokine Res. |volume=19 |issue= 8 |pages= 929-35 |year= 1999 |pmid= 10476940 |doi= 10.1089/107999099313479 }}
+*{{cite journal  |vauthors=Kreda SM, Gynn MC, Fenstermacher DA |title=Expression and localization of epithelial aquaporins in the adult human lung. |journal=Am. J. Respir. Cell Mol. Biol. |volume=24 |issue= 3 |pages= 224–34 |year= 2001 |pmid= 11245621 |doi=  10.1165/ajrcmb.24.3.4367|display-authors=etal}}
-*{{cite journal  | author=Kreda SM, Gynn MC, Fenstermacher DA, ''et al.'' |title=Expression and localization of epithelial aquaporins in the adult human lung. |journal=Am. J. Respir. Cell Mol. Biol. |volume=24 |issue= 3 |pages= 224-34 |year= 2001 |pmid= 11245621 |doi=  }}
+*{{cite journal  |vauthors=Gresz V, Kwon TH, Hurley PT |title=Identification and localization of aquaporin water channels in human salivary glands. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=281 |issue= 1 |pages= G247–54 |year= 2001 |pmid= 11408278 |doi=  |display-authors=etal}}
-*{{cite journal  | author=Gresz V, Kwon TH, Hurley PT, ''et al.'' |title=Identification and localization of aquaporin water channels in human salivary glands. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=281 |issue= 1 |pages= G247-54 |year= 2001 |pmid= 11408278 |doi=  }}
+*{{cite journal  |vauthors=Nejsum LN, Kwon TH, Jensen UB |title=Functional requirement of aquaporin-5 in plasma membranes of sweat glands. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 1 |pages= 511–6 |year= 2002 |pmid= 11773623 |doi= 10.1073/pnas.012588099  | pmc=117591 |display-authors=etal|url=http://ecommons.udayton.edu/cgi/viewcontent.cgi?article=1138&context=bio_fac_pub }}
-*{{cite journal  | author=Nejsum LN, Kwon TH, Jensen UB, ''et al.'' |title=Functional requirement of aquaporin-5 in plasma membranes of sweat glands. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 1 |pages= 511-6 |year= 2002 |pmid= 11773623 |doi= 10.1073/pnas.012588099 }}
+*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  |vauthors=Burghardt B, Elkaer ML, Kwon TH |title=Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas. |journal=Gut |volume=52 |issue= 7 |pages= 1008–16 |year= 2003 |pmid= 12801959 |doi=10.1136/gut.52.7.1008  | pmc=1773699  |display-authors=etal}}
-*{{cite journal  | author=Burghardt B, Elkaer ML, Kwon TH, ''et al.'' |title=Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas. |journal=Gut |volume=52 |issue= 7 |pages= 1008-16 |year= 2003 |pmid= 12801959 |doi=  }}
+*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
+*{{cite journal  |vauthors=Chen Z, Wang X, Gao L |title=Regulation of MUC5AC mucin secretion by depletion of AQP5 in SPC-A1 cells. |journal=Biochem. Biophys. Res. Commun. |volume=342 |issue= 3 |pages= 775–81 |year= 2006 |pmid= 16500622 |doi= 10.1016/j.bbrc.2006.01.103 |display-authors=etal}}
-*{{cite journal  | author=Chen Z, Wang X, Gao L, ''et al.'' |title=Regulation of MUC5AC mucin secretion by depletion of AQP5 in SPC-A1 cells. |journal=Biochem. Biophys. Res. Commun. |volume=342 |issue= 3 |pages= 775-81 |year= 2006 |pmid= 16500622 |doi= 10.1016/j.bbrc.2006.01.103 }}
+*{{cite journal  |vauthors=Sidhaye VK, Güler AD, Schweitzer KS |title=Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 12 |pages= 4747–52 |year= 2006 |pmid= 16537379 |doi= 10.1073/pnas.0511211103  | pmc=1450241 |display-authors=etal}}
-*{{cite journal  | author=Sidhaye VK, Güler AD, Schweitzer KS, ''et al.'' |title=Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 12 |pages= 4747-52 |year= 2006 |pmid= 16537379 |doi= 10.1073/pnas.0511211103 }}
+*{{cite journal  |vauthors=Pedersen PS, Braunstein TH, Jørgensen A |title=Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stress. |journal=Pflügers Arch. |volume=453 |issue= 6 |pages= 777–85 |year= 2007 |pmid= 17043812 |doi= 10.1007/s00424-006-0157-3 |display-authors=etal}}
-*{{cite journal  | author=Pedersen PS, Braunstein TH, Jørgensen A, ''et al.'' |title=Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stress. |journal=Pflugers Arch. |volume=453 |issue= 6 |pages= 777-85 |year= 2007 |pmid= 17043812 |doi= 10.1007/s00424-006-0157-3 }}
+*{{cite journal  |vauthors=Skowron-zwarg M, Boland S, Caruso N |title=Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation. |journal=Exp. Cell Res. |volume=313 |issue= 12 |pages= 2695–702 |year= 2007 |pmid= 17553491 |doi= 10.1016/j.yexcr.2007.02.035 |display-authors=etal}}
-*{{cite journal  | author=Skowron-zwarg M, Boland S, Caruso N, ''et al.'' |title=Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation. |journal=Exp. Cell Res. |volume=313 |issue= 12 |pages= 2695-702 |year= 2007 |pmid= 17553491 |doi= 10.1016/j.yexcr.2007.02.035 }}
 }}
 {{refend}}
@@ Line 84: / Line 37: @@
 == External links ==
 * {{MeshName|AQP5+protein,+human}}
+* {{UCSC gene info|AQP5}}
+{{NLM content}}
+{{Ion channels|g4}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
 {{membrane-protein-stub}}
-{{NLM content}}
-{{Ion channels}}
-{{WikiDoc Sources}}

AQP5: Difference between revisions

Latest revision as of 14:22, 4 November 2018

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References

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