GMP synthase

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Guanine monphosphate synthetase
Symbols GMPS ;
External IDs Template:OMIM5 Template:MGI HomoloGene68367
RNA expression pattern
PBB GE GMPS 214431 at tn.png
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Guanine monphosphate synthetase, also known as GMPS is an enzyme that converts xanthosine monophosphate to guanosine monophosphate.[1]

In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.[1]


  1. 1.0 1.1 "Entrez Gene: GMPS guanine monphosphate synthetase".

Further reading

  • Page T, Bakay B, Nyhan WL (1984). "Human GMP synthetase". Int. J. Biochem. 16 (1): 117–20. PMID 6698284.
  • Nakamura J, Straub K, Wu J, Lou L (1995). "The glutamine hydrolysis function of human GMP synthetase. Identification of an essential active site cysteine". J. Biol. Chem. 270 (40): 23450–5. PMID 7559506.
  • Nakamura J, Lou L (1995). "Biochemical characterization of human GMP synthetase". J. Biol. Chem. 270 (13): 7347–53. PMID 7706277.
  • Hirst M, Haliday E, Nakamura J, Lou L (1994). "Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA". J. Biol. Chem. 269 (38): 23830–7. PMID 8089153.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
  • Fedorova L, Kost-Alimova M, Gizatullin RZ; et al. (1997). "Assignment and ordering of twenty-three unique NotI-linking clones containing expressed genes including the guanosine 5'-monophosphate synthetase gene to human chromosome 3". Eur. J. Hum. Genet. 5 (2): 110–6. PMID 9195163.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
  • Pegram LD, Megonigal MD, Lange BJ; et al. (2001). "t(3;11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (GUANOSINE 5' MONOPHOSPHATE SYNTHETASE) gene". Blood. 96 (13): 4360–2. PMID 11110714.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Guo D, Han J, Adam BL; et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.

External links


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