Succinyl coenzyme A synthetase

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Succinyl coenzyme A synthetase (succinate thiokinase) catalyzes the formation of succinate and coenzyme-A, a 4-carbon metabolite, from succinyl-CoA.


Succinyl-CoA synthetase catalyzes a reversible step in the citric acid cycle, which involves the substrate-level phosphorylation of GDP.


Johnson et al. describe two isoforms of Succinyl-CoA synthetase in mammals, one which specifically uses ATP for synthesis, and one which utilizes GTP. [1]

The GTP form is the one more commonly used in the human citric acid cycle.


The crystal structure of Succinyl-CoA synthetase alpha subunit (ATP-binding isoform) was determined by Joyce et al. to a resolution of 2.10 A, with PDB code 1CQJ. [1].[2]


  1. Johnson, J. D., Mehus, J. G., Tews, K., Milabetz, B. I., and Lambeth, D. O. (1998) J. Biol.Chem. 273, 27580-27586
  2. Joyce, M. A., Fraser, M. E., James, M. N. G., Bridger, W. A., and Wolodko, W. T. (2000) Biochemistry 39, 17-25

External links

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