The salvaged bases and nucleosides can then be converted back into nucleotides.
The salvage pathway requires distinct substrates:
|hypoxanthine||hypoxanthine/guanine phosphoribosyl transferase (HGPRT)||IMP|
|guanine||hypoxanthine/guanine phosphoribosyl transferase (HGPRT)||GMP|
|adenine||adenine phosphoribosyltransferase (APRT)||AMP|
Lesch-Nyhan syndrome is associated with a deficiency of HGPRT.
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