Amenorrhea classification

Jump to navigation Jump to search

Amenorrhea Microchapters


Patient Information

Primary amenorrhea
Secondary amenorrhea


Historical Perspective




Differentiating Amenorrhea from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis


Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings



Echocardiography and Ultrasound

CT scan


Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Amenorrhea classification On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Amenorrhea classification

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical

US National Guidelines Clearinghouse

NICE Guidance

FDA on Amenorrhea classification

CDC on Amenorrhea classification

Amenorrhea classification in the news

Blogs on Amenorrhea classification

Directions to Hospitals Treating Amenorrhea

Risk calculators and risk factors for Amenorrhea classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]


Amenorrhea can be classified on the basis of etiology into three subtypes, including primary amenorrhea, secondary amenorrhea, and functional amenorrhea. Primary amenorrhea can also be classified on the basis of HPG (hypothalamic-pituitary-gonadal) axis function into hypergonadotropic hypogonadism, hypogonadotropic hypogonadism, and eugonadotropic state. Secondary amenorrhea reflects an absence of menstrual cycle for at least 3 months in a woman with normal menstruation cycles in the past. Secondary amenorrhea can be classified based on pathology into polycystic ovary syndrome, hypothalamic-pituitary dysfunction, hypothalamic-pituitary failure, and ovarian failure. Functional (hypothalamic) amenorrhea is a subtype of the amenorrhea seen in patients with erratic lifestyle and can be classified on the basis of etiology into stress, weight loss, and exercise related amenorrhea.


  • Amenorrhea may be classified according to etiology into three subtypes:
    • Primary amenorrhea
    • Secondary amenorrhea
    • Functional amenorrhea
  • Each of the subtypes of amenorrhea has their own classifications, as following:

Amenorrhea classification
Lifestyle etiology
Lack of menarche
Mensturation absence
more than 3 months
Functional amenorrhea
Secondary amenorrhea
Stress related
Weight loss related
Exercise related
Polycystic ovary syndrome
Hypothalamic-pituitary dysfunction
Hypothalamic-pituitary failure
Ovarian failure
Primary amenorrhea
Present uterus
Absent uterus
Hypergonadotropic hypogonadism
Hypogonadotropic hypogonadism
Mullerian agenesis
Androgen insensitivity

Primary amenorrhea

Secondary amenorrhea

Functional amenorrhea


  1. 1.0 1.1 "Current evaluation of amenorrhea". Fertil. Steril. 90 (5 Suppl): S219–25. 2008. doi:10.1016/j.fertnstert.2008.08.038. PMID 19007635.
  2. Fritz, Marc (2011). Clinical gynecologic endocrinology and infertility. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. ISBN 9780781779685.
  3. Euling SY, Herman-Giddens ME, Lee PA, Selevan SG, Juul A, Sørensen TI, Dunkel L, Himes JH, Teilmann G, Swan SH (2008). "Examination of US puberty-timing data from 1940 to 1994 for secular trends: panel findings". Pediatrics. 121 Suppl 3: S172–91. doi:10.1542/peds.2007-1813D. PMID 18245511.
  4. Reindollar, Richard H.; Novak, Michael; Tho, Sandra P.T.; McDonough, Paul G. (1986). "Adult-onset amenorrhea: A study of 262 patients". American Journal of Obstetrics and Gynecology. 155 (3): 531–541. doi:10.1016/0002-9378(86)90274-7. ISSN 0002-9378.
  5. Reindollar RH, Byrd JR, McDonough PG (1981). "Delayed sexual development: a study of 252 patients". Am. J. Obstet. Gynecol. 140 (4): 371–80. PMID 7246652.
  6. Meczekalski B, Podfigurna-Stopa A, Warenik-Szymankiewicz A, Genazzani AR (2008). "Functional hypothalamic amenorrhea: current view on neuroendocrine aberrations". Gynecol. Endocrinol. 24 (1): 4–11. doi:10.1080/09513590701807381. PMID 18224538.
  7. Liu JH, Bill AH (2008). "Stress-associated or functional hypothalamic amenorrhea in the adolescent". Ann. N. Y. Acad. Sci. 1135: 179–84. doi:10.1196/annals.1429.027. PMID 18574223.
  8. Gordon, Catherine M. (2010). "Functional Hypothalamic Amenorrhea". New England Journal of Medicine. 363 (4): 365–371. doi:10.1056/NEJMcp0912024. ISSN 0028-4793.

Template:WH Template:WS