Pheochromocytoma history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
The hallmarks of [[pheochromocytoma]] is recurrent episodes of sympathetic symptoms. The most common [[Symptom|symptoms]] of pheochromocytoma include episodes of [[palpitations]], [[sweating]] and [[headaches]]. Less common [[symptoms]] include [[cardiomyopathy|cardiomypathy]], episodic [[hypotension]], [[symptoms]] of other [[Multiple endocrine neoplasia|multiple endocrine neoplasias]] associated diseases such as that of [[medullary thyroid cancer]] and [[hyperparathyroidism]]. | |||
==History == | ==History and Symptoms== | ||
The hallmark of [[pheochromocytoma]] is recurrent episodes of [[Palpitation|palpitations]], [[sweating]], and [[headache]]. | |||
=== | ===History=== | ||
Patients with [[pheochromocytoma]] may have a positive history of: | |||
*Recurrent attacks of [[palpitations]] | |||
* [[Family history]] of [[Multiple endocrine neoplasia type 2| | *[[Headache]] and [[Perspiration|sweating]] | ||
*Paroxysmal changes in [[blood pressure]] | |||
*[[Family history]] of [[pheochromocytoma]] | |||
*Family history of syndromes- [[MEN2|MEN 2A]], [[Multiple endocrine neoplasia type 2|MEN 2B]], [[NF1]], [[Von Hippel-Lindau disease|VHL]] | |||
===Common symptoms=== | ===Common symptoms=== | ||
Common symptoms of pheochromocytoma are secondary to [[sympathetic nervous system]] hyperactivity. [[Symptoms]] usually subside in less than one hour and they may include: | Common symptoms of [[pheochromocytoma]] are secondary to [[sympathetic nervous system]] hyperactivity. [[Symptoms]] usually subside in less than one hour and they may include: | ||
*[[Palpitations]] especially in epinephrine producing tumors.<ref name="pmid8325290">{{cite journal| author=Bravo EL, Gifford RW| title=Pheochromocytoma. | journal=Endocrinol Metab Clin North Am | year= 1993 | volume= 22 | issue= 2 | pages= 329-41 | pmid=8325290 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8325290 }}</ref> | *[[Palpitations]] especially in epinephrine producing tumors.<ref name="pmid8325290">{{cite journal| author=Bravo EL, Gifford RW| title=Pheochromocytoma. | journal=Endocrinol Metab Clin North Am | year= 1993 | volume= 22 | issue= 2 | pages= 329-41 | pmid=8325290 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8325290 }}</ref> | ||
*[[Anxiety]] often resembling that of a [[panic attack]] | *[[Anxiety]] often resembling that of a [[panic attack]] | ||
*[[Sweating]] | *[[Sweating]] | ||
*[[Headaches]] | *[[Headaches]] | ||
*Paroxysmal attacks of [[hypertension]] but some patients have normal [[blood pressure]] | *Paroxysmal attacks of [[hypertension]] but some patients have normal [[blood pressure]] | ||
*Pheochromocytoma may be [[asymptomatic]] and discovered incidentally after [[Screening (medicine)|screening]] for [[MEN, type 2|MEN]] patients | *Pheochromocytoma may be [[asymptomatic]] and discovered incidentally after [[Screening (medicine)|screening]] for [[MEN, type 2|MEN]] patients | ||
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* [[Cardiomyopathy]]: [[dyspnea on exertion]], [[leg swelling]], painful [[hepatomegaly]].<ref name="pmid19158054">{{cite journal| author=Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM| title=Catecholamine-induced cardiomyopathy. | journal=Endocr Pract | year= 2008 | volume= 14 | issue= 9 | pages= 1137-49 | pmid=19158054 | doi=10.4158/EP.14.9.1137 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19158054 }}</ref> | * [[Cardiomyopathy]]: [[dyspnea on exertion]], [[leg swelling]], painful [[hepatomegaly]].<ref name="pmid19158054">{{cite journal| author=Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM| title=Catecholamine-induced cardiomyopathy. | journal=Endocr Pract | year= 2008 | volume= 14 | issue= 9 | pages= 1137-49 | pmid=19158054 | doi=10.4158/EP.14.9.1137 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19158054 }}</ref> | ||
* Episodic [[hypotension]].<ref name="pmid8076587">{{cite journal| author=Bravo EL| title=Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma. | journal=Endocr Rev | year= 1994 | volume= 15 | issue= 3 | pages= 356-68 | pmid=8076587 | doi=10.1210/edrv-15-3-356 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8076587 }}</ref> | * Episodic [[hypotension]].<ref name="pmid8076587">{{cite journal| author=Bravo EL| title=Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma. | journal=Endocr Rev | year= 1994 | volume= 15 | issue= 3 | pages= 356-68 | pmid=8076587 | doi=10.1210/edrv-15-3-356 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8076587 }}</ref> | ||
* Pheochromocytoma patients may show symptoms of other diseases associated with syndromes such as: | |||
**[[Multiple endocrine neoplasia type 2|MEN 2]] | |||
Pheochromocytoma patients may show symptoms of other diseases | *** [[Hyperparathyroidism]] | ||
* [[Hyperparathyroidism]] | *** [[Marfan's syndrome|Marfanoid features]] | ||
* [[Marfan's syndrome|Marfanoid features]] | *** [[Medullary thyroid cancer]] | ||
* [[Medullary thyroid cancer]] | **[[Von Hippel-Lindau Disease|Von Hippel-Lindau disease]] | ||
* | ***[[Angiomatosis]] | ||
***[[Hemangioblastoma]]s | |||
***[[Renal cell carcinoma]] | |||
***[[Cyst|Cysts]]/[[Tumor|tumors]] of the [[pancreas]]. <ref name="pmid10458336">{{cite journal| author=Walther MM, Reiter R, Keiser HR, Choyke PL, Venzon D, Hurley K et al.| title=Clinical and genetic characterization of pheochromocytoma in von Hippel-Lindau families: comparison with sporadic pheochromocytoma gives insight into natural history of pheochromocytoma. | journal=J Urol | year= 1999 | volume= 162 | issue= 3 Pt 1 | pages= 659-64 | pmid=10458336 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10458336 }}</ref> | |||
=References= | =References= | ||
Latest revision as of 20:45, 28 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]Mohammed Abdelwahed M.D[3]
Overview
The hallmarks of pheochromocytoma is recurrent episodes of sympathetic symptoms. The most common symptoms of pheochromocytoma include episodes of palpitations, sweating and headaches. Less common symptoms include cardiomypathy, episodic hypotension, symptoms of other multiple endocrine neoplasias associated diseases such as that of medullary thyroid cancer and hyperparathyroidism.
History and Symptoms
The hallmark of pheochromocytoma is recurrent episodes of palpitations, sweating, and headache.
History
Patients with pheochromocytoma may have a positive history of:
- Recurrent attacks of palpitations
- Headache and sweating
- Paroxysmal changes in blood pressure
- Family history of pheochromocytoma
- Family history of syndromes- MEN 2A, MEN 2B, NF1, VHL
Common symptoms
Common symptoms of pheochromocytoma are secondary to sympathetic nervous system hyperactivity. Symptoms usually subside in less than one hour and they may include:
- Palpitations especially in epinephrine producing tumors.[1]
- Anxiety often resembling that of a panic attack
- Sweating
- Headaches
- Paroxysmal attacks of hypertension but some patients have normal blood pressure
- Pheochromocytoma may be asymptomatic and discovered incidentally after screening for MEN patients
Less common symptoms
Less common symptoms of pheochromocytoma include:
- Cardiomyopathy: dyspnea on exertion, leg swelling, painful hepatomegaly.[2]
- Episodic hypotension.[3]
- Pheochromocytoma patients may show symptoms of other diseases associated with syndromes such as:
References
- ↑ Bravo EL, Gifford RW (1993). "Pheochromocytoma". Endocrinol Metab Clin North Am. 22 (2): 329–41. PMID 8325290.
- ↑ Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM (2008). "Catecholamine-induced cardiomyopathy". Endocr Pract. 14 (9): 1137–49. doi:10.4158/EP.14.9.1137. PMID 19158054.
- ↑ Bravo EL (1994). "Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma". Endocr Rev. 15 (3): 356–68. doi:10.1210/edrv-15-3-356. PMID 8076587.
- ↑ Walther MM, Reiter R, Keiser HR, Choyke PL, Venzon D, Hurley K; et al. (1999). "Clinical and genetic characterization of pheochromocytoma in von Hippel-Lindau families: comparison with sporadic pheochromocytoma gives insight into natural history of pheochromocytoma". J Urol. 162 (3 Pt 1): 659–64. PMID 10458336.