Pheochromocytoma history and symptoms: Difference between revisions

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==Overview==
==Overview==
Common [[Symptom|symptoms]] of pheochromocytoma include episodes of [[palpitations]], [[sweating]] and [[headaches]].<ref name="pmid1988766">{{cite journal| author=Stein PP, Black HR| title=A simplified diagnostic approach to pheochromocytoma. A review of the literature and report of one institution's experience. | journal=Medicine (Baltimore) | year= 1991 | volume= 70 | issue= 1 | pages= 46-66 | pmid=1988766 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1988766  }}</ref> Most patients are [[asymptomatic]]. Less common [[symptoms]] include [[cardiomyopathy|cardiomypathy]] and episodic [[hypotension]].<ref name="pmid15132724">{{cite journal| author=Baguet JP, Hammer L, Mazzuco TL, Chabre O, Mallion JM, Sturm N et al.| title=Circumstances of discovery of phaeochromocytoma: a retrospective study of 41 consecutive patients. | journal=Eur J Endocrinol | year= 2004 | volume= 150 | issue= 5 | pages= 681-6 | pmid=15132724 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15132724  }}</ref> Patients may have a history of recurrent attacks of [[palpitation]] or [[family history]] of pheochromocytoma. Patients may show [[symptoms]] of other [[Multiple endocrine neoplasia|multiple endocrine neoplasias]] associated diseases such as that of [[medullary thyroid cancer]] and [[hyperparathyroidism]].
The hallmarks of [[pheochromocytoma]] is recurrent episodes of sympathetic symptoms. The most common [[Symptom|symptoms]] of pheochromocytoma include episodes of [[palpitations]], [[sweating]] and [[headaches]]. Less common [[symptoms]] include [[cardiomyopathy|cardiomypathy]], episodic [[hypotension]], [[symptoms]] of other [[Multiple endocrine neoplasia|multiple endocrine neoplasias]] associated diseases such as that of [[medullary thyroid cancer]] and [[hyperparathyroidism]].


==History ==
==History and Symptoms==
The hallmark of [[pheochromocytoma]] is recurrent episodes of [[Palpitation|palpitations]], [[sweating]], and [[headache]].


=== Past medical history ===
===History===
* Patients suffering from pheochromocytoma may have a positive past medical history of recurrent attacks of [[palpitation]] or [[Panic attack|panic attacks]].
Patients with [[pheochromocytoma]] may have a positive history of:


=== Family history ===
*Recurrent attacks of [[palpitations]]
* [[Family history]] of [[Multiple endocrine neoplasia type 2|MEN2B]] increases chances of familial pheochromocytoma.
*[[Headache]] and [[Perspiration|sweating]]
*Paroxysmal changes in [[blood pressure]]
*[[Family history]] of [[pheochromocytoma]]
*Family history of syndromes- [[MEN2|MEN 2A]], [[Multiple endocrine neoplasia type 2|MEN 2B]], [[NF1]], [[Von Hippel-Lindau disease|VHL]]


== Symptoms ==
===Common symptoms===
 
Common symptoms of [[pheochromocytoma]] are secondary to [[sympathetic nervous system]] hyperactivity. [[Symptoms]] usually subside in less than one hour and they may include:
===Common Symptoms===
Common symptoms of pheochromocytoma are secondary to [[sympathetic nervous system]] hyperactivity. [[Symptoms]] usually subside in less than one hour and they may include:


*[[Palpitations]] especially in epinephrine producing tumors.<ref name="pmid8325290">{{cite journal| author=Bravo EL, Gifford RW| title=Pheochromocytoma. | journal=Endocrinol Metab Clin North Am | year= 1993 | volume= 22 | issue= 2 | pages= 329-41 | pmid=8325290 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8325290  }}</ref>
*[[Palpitations]] especially in epinephrine producing tumors.<ref name="pmid8325290">{{cite journal| author=Bravo EL, Gifford RW| title=Pheochromocytoma. | journal=Endocrinol Metab Clin North Am | year= 1993 | volume= 22 | issue= 2 | pages= 329-41 | pmid=8325290 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8325290  }}</ref>
*[[Anxiety]] often resembling that of a [[panic attack]]
*[[Anxiety]] often resembling that of a [[panic attack]]
*[[Sweating]]
*[[Sweating]]
*[[Headaches]] occurs in 90 % of patients.
*[[Headaches]] 
*Paroxysmal attacks of [[hypertension]] but some patients have normal [[blood pressure]].
*Paroxysmal attacks of [[hypertension]] but some patients have normal [[blood pressure]]
*It may be [[asymptomatic]] and discovered incidentally after [[Screening (medicine)|screening]] for [[MEN, type 2|MEN]] patients.
*Pheochromocytoma may be [[asymptomatic]] and discovered incidentally after [[Screening (medicine)|screening]] for [[MEN, type 2|MEN]] patients
 
=== Less Common Symptoms ===
Less common symptoms include:
* [[Cardiomyopathy]]: rare symptom due to [[catecholamine]] excess mimics [[takotsubo cardiomyopathy]].<ref name="pmid19158054">{{cite journal| author=Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM| title=Catecholamine-induced cardiomyopathy. | journal=Endocr Pract | year= 2008 | volume= 14 | issue= 9 | pages= 1137-49 | pmid=19158054 | doi=10.4158/EP.14.9.1137 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19158054  }}</ref> Patient improves after medical treatment or surgical removal of the tumor.
* [[Epinephrine]] secreting masses can cause episodic [[hypotension]].<ref name="pmid8076587">{{cite journal| author=Bravo EL| title=Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma. | journal=Endocr Rev | year= 1994 | volume= 15 | issue= 3 | pages= 356-68 | pmid=8076587 | doi=10.1210/edrv-15-3-356 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8076587  }}</ref>


=== Symptoms of Associated diseases ===
=== Less common symptoms ===
Pheochromocytoma patients may show symptoms of other diseases in MEN2 syndromes such as:
Less common symptoms of pheochromocytoma include:
* [[Hyperparathyroidism]]
* [[Cardiomyopathy]]: [[dyspnea on exertion]], [[leg swelling]], painful [[hepatomegaly]].<ref name="pmid19158054">{{cite journal| author=Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM| title=Catecholamine-induced cardiomyopathy. | journal=Endocr Pract | year= 2008 | volume= 14 | issue= 9 | pages= 1137-49 | pmid=19158054 | doi=10.4158/EP.14.9.1137 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19158054  }}</ref>
* [[Marfan's syndrome|Marfanoid features]]
* Episodic [[hypotension]].<ref name="pmid8076587">{{cite journal| author=Bravo EL| title=Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma. | journal=Endocr Rev | year= 1994 | volume= 15 | issue= 3 | pages= 356-68 | pmid=8076587 | doi=10.1210/edrv-15-3-356 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8076587  }}</ref>
* [[Medullary thyroid cancer]]
* Pheochromocytoma patients may show symptoms of other diseases associated with syndromes such as:
* The patient may show symptoms associated with [[Von Hippel-Lindau Disease|von Hippel-Lindau]]: The mean age at presentation is about 30 years. The onset can sometimes be before the age of 10. <ref name="pmid10458336">{{cite journal| author=Walther MM, Reiter R, Keiser HR, Choyke PL, Venzon D, Hurley K et al.| title=Clinical and genetic characterization of pheochromocytoma in von Hippel-Lindau families: comparison with sporadic pheochromocytoma gives insight into natural history of pheochromocytoma. | journal=J Urol | year= 1999 | volume= 162 | issue= 3 Pt 1 | pages= 659-64 | pmid=10458336 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10458336  }}</ref>
**[[Multiple endocrine neoplasia type 2|MEN 2]]
*** [[Hyperparathyroidism]]
*** [[Marfan's syndrome|Marfanoid features]]
*** [[Medullary thyroid cancer]]
**[[Von Hippel-Lindau Disease|Von Hippel-Lindau disease]]
***[[Angiomatosis]]
***[[Hemangioblastoma]]s
***[[Renal cell carcinoma]]
***[[Cyst|Cysts]]/[[Tumor|tumors]] of the [[pancreas]]. <ref name="pmid10458336">{{cite journal| author=Walther MM, Reiter R, Keiser HR, Choyke PL, Venzon D, Hurley K et al.| title=Clinical and genetic characterization of pheochromocytoma in von Hippel-Lindau families: comparison with sporadic pheochromocytoma gives insight into natural history of pheochromocytoma. | journal=J Urol | year= 1999 | volume= 162 | issue= 3 Pt 1 | pages= 659-64 | pmid=10458336 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10458336  }}</ref>


=References=
=References=

Latest revision as of 20:45, 28 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]Mohammed Abdelwahed M.D[3]

Overview

The hallmarks of pheochromocytoma is recurrent episodes of sympathetic symptoms. The most common symptoms of pheochromocytoma include episodes of palpitations, sweating and headaches. Less common symptoms include cardiomypathy, episodic hypotension, symptoms of other multiple endocrine neoplasias associated diseases such as that of medullary thyroid cancer and hyperparathyroidism.

History and Symptoms

The hallmark of pheochromocytoma is recurrent episodes of palpitations, sweating, and headache.

History

Patients with pheochromocytoma may have a positive history of:

Common symptoms

Common symptoms of pheochromocytoma are secondary to sympathetic nervous system hyperactivity. Symptoms usually subside in less than one hour and they may include:

Less common symptoms

Less common symptoms of pheochromocytoma include:

References

  1. Bravo EL, Gifford RW (1993). "Pheochromocytoma". Endocrinol Metab Clin North Am. 22 (2): 329–41. PMID 8325290.
  2. Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM (2008). "Catecholamine-induced cardiomyopathy". Endocr Pract. 14 (9): 1137–49. doi:10.4158/EP.14.9.1137. PMID 19158054.
  3. Bravo EL (1994). "Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma". Endocr Rev. 15 (3): 356–68. doi:10.1210/edrv-15-3-356. PMID 8076587.
  4. Walther MM, Reiter R, Keiser HR, Choyke PL, Venzon D, Hurley K; et al. (1999). "Clinical and genetic characterization of pheochromocytoma in von Hippel-Lindau families: comparison with sporadic pheochromocytoma gives insight into natural history of pheochromocytoma". J Urol. 162 (3 Pt 1): 659–64. PMID 10458336.

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