Pheochromocytoma history and symptoms: Difference between revisions

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{{Pheochromocytoma}}
{{Pheochromocytoma}}
{{CMG}}; {{AE}} {{AAM}}
{{CMG}} {{AE}} {{AAM}}{{MAD}}


==Overview==
==Overview==
Symptoms of pheochromocytoma include [[palpitations]], [[anxiety]], and [[headaches]].
The hallmarks of [[pheochromocytoma]] is recurrent episodes of sympathetic symptoms. The most common [[Symptom|symptoms]] of pheochromocytoma include episodes of [[palpitations]], [[sweating]] and [[headaches]]. Less common [[symptoms]] include [[cardiomyopathy|cardiomypathy]], episodic [[hypotension]], [[symptoms]] of other [[Multiple endocrine neoplasia|multiple endocrine neoplasias]] associated diseases such as that of [[medullary thyroid cancer]] and [[hyperparathyroidism]].


==History and Symptoms==
==History and Symptoms==
The [[symptoms]] of a pheochromocytoma are those of [[sympathetic nervous system]] hyperactivity, symptoms usually subside in less than one hour and they may include:
The hallmark of [[pheochromocytoma]] is recurrent episodes of [[Palpitation|palpitations]], [[sweating]], and [[headache]].


*[[Palpitations]]
===History===
Patients with [[pheochromocytoma]] may have a positive history of:
 
*Recurrent attacks of [[palpitations]]
*[[Headache]] and [[Perspiration|sweating]]
*Paroxysmal changes in [[blood pressure]]
*[[Family history]] of [[pheochromocytoma]]
*Family history of syndromes- [[MEN2|MEN 2A]], [[Multiple endocrine neoplasia type 2|MEN 2B]], [[NF1]], [[Von Hippel-Lindau disease|VHL]]
 
===Common symptoms===
Common symptoms of [[pheochromocytoma]] are secondary to [[sympathetic nervous system]] hyperactivity. [[Symptoms]] usually subside in less than one hour and they may include:
 
*[[Palpitations]] especially in epinephrine producing tumors.<ref name="pmid8325290">{{cite journal| author=Bravo EL, Gifford RW| title=Pheochromocytoma. | journal=Endocrinol Metab Clin North Am | year= 1993 | volume= 22 | issue= 2 | pages= 329-41 | pmid=8325290 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8325290  }}</ref>
*[[Anxiety]] often resembling that of a [[panic attack]]
*[[Anxiety]] often resembling that of a [[panic attack]]
*[[Diaphoresis]]
*[[Sweating]]
*[[Headaches]]
*[[Headaches]] 
*[[Pallor]]
*Paroxysmal attacks of [[hypertension]] but some patients have normal [[blood pressure]]
*[[Weight loss]]
*Pheochromocytoma may be [[asymptomatic]] and discovered incidentally after [[Screening (medicine)|screening]] for [[MEN, type 2|MEN]] patients


''Please note that not all patients with pheochromocytoma experience the classical symptoms''.
=== Less common symptoms ===
Less common symptoms of pheochromocytoma include:
* [[Cardiomyopathy]]: [[dyspnea on exertion]], [[leg swelling]], painful [[hepatomegaly]].<ref name="pmid19158054">{{cite journal| author=Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM| title=Catecholamine-induced cardiomyopathy. | journal=Endocr Pract | year= 2008 | volume= 14 | issue= 9 | pages= 1137-49 | pmid=19158054 | doi=10.4158/EP.14.9.1137 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19158054  }}</ref>
* Episodic [[hypotension]].<ref name="pmid8076587">{{cite journal| author=Bravo EL| title=Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma. | journal=Endocr Rev | year= 1994 | volume= 15 | issue= 3 | pages= 356-68 | pmid=8076587 | doi=10.1210/edrv-15-3-356 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8076587  }}</ref>
* Pheochromocytoma patients may show symptoms of other diseases associated with syndromes such as:
**[[Multiple endocrine neoplasia type 2|MEN 2]]
*** [[Hyperparathyroidism]]
*** [[Marfan's syndrome|Marfanoid features]]
*** [[Medullary thyroid cancer]]
**[[Von Hippel-Lindau Disease|Von Hippel-Lindau disease]]
***[[Angiomatosis]]
***[[Hemangioblastoma]]s
***[[Renal cell carcinoma]]
***[[Cyst|Cysts]]/[[Tumor|tumors]] of the [[pancreas]]. <ref name="pmid10458336">{{cite journal| author=Walther MM, Reiter R, Keiser HR, Choyke PL, Venzon D, Hurley K et al.| title=Clinical and genetic characterization of pheochromocytoma in von Hippel-Lindau families: comparison with sporadic pheochromocytoma gives insight into natural history of pheochromocytoma. | journal=J Urol | year= 1999 | volume= 162 | issue= 3 Pt 1 | pages= 659-64 | pmid=10458336 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10458336  }}</ref>


==References==
=References=
{{Reflist|2}}
{{Reflist|2}}


[[Category:Endocrinology]]
[[Category:Endocrinology]]


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Latest revision as of 20:45, 28 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]Mohammed Abdelwahed M.D[3]

Overview

The hallmarks of pheochromocytoma is recurrent episodes of sympathetic symptoms. The most common symptoms of pheochromocytoma include episodes of palpitations, sweating and headaches. Less common symptoms include cardiomypathy, episodic hypotension, symptoms of other multiple endocrine neoplasias associated diseases such as that of medullary thyroid cancer and hyperparathyroidism.

History and Symptoms

The hallmark of pheochromocytoma is recurrent episodes of palpitations, sweating, and headache.

History

Patients with pheochromocytoma may have a positive history of:

Common symptoms

Common symptoms of pheochromocytoma are secondary to sympathetic nervous system hyperactivity. Symptoms usually subside in less than one hour and they may include:

Less common symptoms

Less common symptoms of pheochromocytoma include:

References

  1. Bravo EL, Gifford RW (1993). "Pheochromocytoma". Endocrinol Metab Clin North Am. 22 (2): 329–41. PMID 8325290.
  2. Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM (2008). "Catecholamine-induced cardiomyopathy". Endocr Pract. 14 (9): 1137–49. doi:10.4158/EP.14.9.1137. PMID 19158054.
  3. Bravo EL (1994). "Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma". Endocr Rev. 15 (3): 356–68. doi:10.1210/edrv-15-3-356. PMID 8076587.
  4. Walther MM, Reiter R, Keiser HR, Choyke PL, Venzon D, Hurley K; et al. (1999). "Clinical and genetic characterization of pheochromocytoma in von Hippel-Lindau families: comparison with sporadic pheochromocytoma gives insight into natural history of pheochromocytoma". J Urol. 162 (3 Pt 1): 659–64. PMID 10458336.

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