VRK1

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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File:Crystal Structure of the Human vaccinia-related kinase.png
Cartoon diagram of the Human vaccinia-related kinase protein PDB entry 6bru

Serine/threonine-protein kinase VRK1 is an enzyme that in humans is encoded by the VRK1 gene.[1][2]

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and C-jun.[2]

References

  1. Nezu J, Oku A, Jones MH, Shimane M (Feb 1998). "Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase". Genomics. 45 (2): 327–31. doi:10.1006/geno.1997.4938. PMID 9344656.
  2. 2.0 2.1 "Entrez Gene: VRK1 vaccinia related kinase 1".

Further reading