Malate dehydrogenase
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| Structure of the protein with attached sugars | |
| malate dehydrogenase 1, NAD (soluble)
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| Identifiers | |
| Symbol | MDH1 |
| Entrez | 4190 |
| HUGO | 6970 |
| OMIM | 154200 |
| RefSeq | NM_005917 |
| UniProt | P40925 |
| Other data | |
| EC number | 1.1.1.37 |
| Locus | Chr. 2 p23 |
| malate dehydrogenase 2, NAD (mitochondrial)
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| Identifiers | |
| Symbol | MDH2 |
| Entrez | 4191 |
| HUGO | 6971 |
| OMIM | 154100 |
| RefSeq | NM_005918 |
| UniProt | P40926 |
| Other data | |
| EC number | 1.1.1.37 |
| Locus | Chr. 7 cen-q22 |
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Malate dehydrogenase (EC 1.1.1.37) is an enzyme in the citric acid cycle that catalyzes the conversion of malate into oxaloacetate (using NAD+) and vice versa (this is a reversible reaction). Malate dehydrogenase is not to be confused with malic enzyme, which catalyzes the conversion of pyruvate using NADPH.
Malate dehydrogenase is also involved in gluconeogenesis, the synthesis of glucose from smaller molecules. Pyruvate in the mitochondria is acted upon by pyruvate carboxylase to form oxaloacetate, a citric acid cycle intermediate. In order to get the oxaloacetate out of the mitochondria, malate dehydrogenase reduces it to malate, and it then traverses the inner mitochondrial membrane. Once in the cytosol, the malate is oxidized back to oxaloacetate by cytosolic malate dehydrogenase. Finally, phosphoenol-pyruvate carboxy kinase (PEPCK) converts oxaloacetate to phosphoenol pyruvate.
The Cas number for this type of the enzyme is [9001-64-3].
References
- IUBMB entry for 1.1.1.37
- BRENDA references for 1.1.1.37 (Recommended.)
- PubMed references for 1.1.1.37
- PubMed Central references for 1.1.1.37
- Google Scholar references for 1.1.1.37
External links
Oxidoreductases: alcohol oxidoreductases (EC 1.1) | |
|---|---|
| 1.1.1 NAD/NADP acceptor | Carbohydrate dehydrogenases - Alcohol dehydrogenase - Glycerol-3-phosphate dehydrogenase - L-xylulose reductase - Aldose reductase - Lactate dehydrogenase - 3-Hydroxyacyl CoA dehydrogenase - Malate dehydrogenase - Isocitrate dehydrogenase - Phosphogluconate dehydrogenase - Glucose-6-phosphate dehydrogenase - HMG-CoA reductase - Β-Ketoacyl ACP reductase - Hydroxysteroid dehydrogenase: 11 Beta (HSD11B1, HSD11B2) - 3 Beta (3-beta-HSD) - 17 Beta - Carnitine dehydrogenase - Beta-hydroxybutyryl-CoA dehydrogenase - IMP dehydrogenase - DXP reductoisomerase |
| 1.1.3 oxygen acceptor | Glucose oxidase - L-gulonolactone oxidase - Xanthine oxidase |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
