Uncoupling protein
A uncoupling protein is a proton channel which disrupts the gradient before it can be used to provide the energy for oxidative phosphorylation.[1]
There are five types known in mammals:
- UCP1, also known as thermogenin
- UCP2
- UCP3
- SLC25A27, also known as "UCP4"
- SLC25A14, also known as "UCP5"
Uncoupling proteins play a role in normal physiology, as in hibernation, because the energy is used to generate heat (see thermogenesis) instead of producing ATP. However, other substances such as 2,4-Dinitrophenol and CCCP also serve the same uncoupling function, and are considered poisonous.
References
- ↑ Nedergaard J, Ricquier D, Kozak LP (2005). "Uncoupling proteins: current status and therapeutic prospects". EMBO Rep. 6 (10): 917-21. doi:10.1038/sj.embor.7400532. PMID 16179945.
External links
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